New shot could cut opioid use after bunion surgery
NCT ID NCT05831449
First seen Mar 20, 2026 · Last updated Jun 22, 2026 · Updated 8 times
Summary
This Phase 3 trial tested an experimental long-acting local anesthetic called CPL-01 in 616 people having bunion surgery. The goal was to see if it reduces pain and the need for opioid rescue medication compared to a standard anesthetic or placebo. Participants received the injection during surgery and were monitored for pain scores and opioid use afterward.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Todd Bertoch
Salt Lake City, Utah, 84101, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CPL-01 (long-acting ropivacaine local anesthetic injection)
What this could lead to
If successful, CPL-01 could provide longer-lasting pain relief after surgery and reduce the need for opioid painkillers.
What could go wrong
This is a completed Phase 3 trial, but results are not yet public. The effect may be modest, and some people may still need opioids for breakthrough pain.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.