Nanotech tooth pastes could ease pain after root canal failure

NCT ID NCT07571837

Recruiting now Disease control Sponsor: Al-Azhar University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether two nano-sized pastes—nano-calcium hydroxide and nano-chitosan—can reduce inflammation and pain in people who need a second root canal treatment. The trial will enroll 63 adults with a single-rooted tooth that has a persistent infection and no current pain. Researchers will measure levels of inflammatory markers in fluid around the tooth and check pain levels after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nano-calcium hydroxide paste and nano-chitosan paste
What this could lead to: If it works, this could point toward a more effective way to disinfect teeth and reduce pain after a failed root canal.
What could go wrong: This is a small, early-stage trial with only 63 participants, so results may not apply to everyone. The treatments are experimental and may not work better than standard care.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIAPICAL INFLAMMATION POST-OPERATIVE PAIN

Contacts and locations

Locations

Al Azhar University
RECRUITING

Cairo, Nasr City, 11765, Egypt

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