Knee surgery patients may need fewer opioids with one dose of methadone
NCT ID NCT07226076
First seen Nov 10, 2025 · Last updated Jun 18, 2026 · Updated 30 times
Summary
This study tests whether giving a single dose of methadone during knee replacement surgery can lower pain and reduce the need for other opioid painkillers right after the operation. About 162 adults having elective knee replacement will take part. Half will receive methadone and half a placebo, and researchers will compare their pain scores and how much extra pain medicine they need.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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