Knee surgery patients may need fewer opioids with one dose of methadone
NCT ID NCT07226076
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving a single dose of methadone during knee replacement surgery can lower pain and reduce the need for other opioid painkillers right after the operation. About 162 adults having elective knee replacement will take part. Half will receive methadone and half a placebo, and researchers will compare their pain scores and how much extra pain medicine they need.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
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