Vitamin c trial aims to ease persistent pain after knee surgery
NCT ID NCT06123715
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether taking vitamin C around the time of knee replacement surgery can reduce long-term pain. About 400 adults having knee replacement will be randomly assigned to receive vitamin C or a placebo for 8 weeks. The main goal is to see if a larger study is possible, but researchers will also track pain levels for a year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vitamin C (ascorbic acid)
What this could lead to
If it works, this could point toward a simple, low-cost way to reduce chronic pain after knee replacement surgery.
What could go wrong
This is a small pilot study focused on feasibility, not proof of effectiveness. Vitamin C may not reduce pain, and results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mount Sinai Hospital
RECRUITINGToronto, Ontario, M5G 1X5, Canada
Contact Email: •••••@•••••
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Sunnybrook - Holland Centre
RECRUITINGToronto, Ontario, M4Y 1H1, Canada
Contact Email: •••••@•••••
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Toronto Western Hospital
RECRUITINGToronto, Ontario, M5T 2S8, Canada
Contact Email: •••••@•••••