Vitamin c trial aims to ease persistent pain after knee surgery

NCT ID NCT06123715

Recruiting now Symptom relief Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether taking vitamin C around the time of knee replacement surgery can reduce long-term pain. About 400 adults having knee replacement will be randomly assigned to receive vitamin C or a placebo for 8 weeks. The main goal is to see if a larger study is possible, but researchers will also track pain levels for a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vitamin C (ascorbic acid)
What this could lead to: If it works, this could point toward a simple, low-cost way to reduce chronic pain after knee replacement surgery.
What could go wrong: This is a small pilot study focused on feasibility, not proof of effectiveness. Vitamin C may not reduce pain, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CHRONIC PAIN are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome osteoarthritis, knee Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC PAIN KNEE PAIN CHRONIC POST-OPERATIVE PAIN

Contacts and locations

Locations

Mount Sinai Hospital
RECRUITING

Toronto, Ontario, M5G 1X5, Canada
Sunnybrook - Holland Centre
RECRUITING

Toronto, Ontario, M4Y 1H1, Canada
Toronto Western Hospital
RECRUITING

Toronto, Ontario, M5T 2S8, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.