Thomas Jefferson University

This phase I trial tests pyrvinium pamoate, a drug originally used to treat pinworm infections, in people with pancreatic cancer that can be surgically removed. The goal is to find the safest dose and see if it can slow tumor growth. Researchers will monitor side effects and meas…

This phase 2 trial is testing whether giving immunotherapy drugs (cemiplimab alone or with fianlimab) before surgery can shrink advanced basal cell carcinoma of the head and neck. The goal is to make surgery less extensive, preserving important structures like the eye, nose, or l…

This phase 2 trial tests a procedure called transarterial chemoembolization (TACE) for people with uveal melanoma that has spread to the liver. Doctors inject a chemotherapy drug (carmustine) mixed with an oily contrast agent (Lipiodol) directly into the liver's blood supply, the…

This early-phase trial tests whether giving higher doses of radiation, guided by special PET/MRI scans, is safe for people with high-risk meningiomas (aggressive or recurrent brain tumors). About 24 adults will receive one of four radiation dose levels to find the highest dose th…

This early-phase study tested a combination of enzalutamide (a hormone-blocking drug), radiation therapy, and standard hormone therapy in 25 men with intermediate or high-risk prostate cancer. The main goal was to check for side effects and find the best way to give the treatment…

This early-phase trial is testing the safety and best dose of a three-drug combination (venetoclax, lenalidomide, and rituximab) in patients with follicular or marginal zone lymphoma that has returned or not responded to prior treatment. The study enrolled only 4 participants to …

This study tests a device called the RISES-T System, which uses mild electrical stimulation through the skin to help people with chronic spinal cord injury improve their mobility and reduce muscle stiffness. Ten participants will try different stimulation techniques while researc…

This study is testing a new way to detect prostate cancer by looking at cells in urine using a special imaging method. Researchers will collect urine samples from 675 men aged 50-75, including those with and without prostate cancer. The goal is to see if this simple test can accu…

This study aimed to compare two different needles used to take tissue samples from solid masses in the pancreas and digestive tract. The goal was to see which needle provides a more accurate diagnosis. The study was planned for adults needing this procedure, but it was withdrawn …

This study tests a wearable device that listens to breathing sounds through a sensor on the throat. It aims to detect and predict opioid-induced respiratory depression (slow or stopped breathing) in 120 adults recovering from surgery. The device's accuracy will be compared to sta…

This phase III trial is testing whether a special ultrasound contrast agent, called Definity, can help doctors see prostate cancer on ultrasound images. The study involves 70 men scheduled for prostate removal surgery. Before surgery, they receive an IV of Definity, which contain…

This study looks at whether taking ketone or hawthorn supplements for 8 weeks can improve exercise ability and heart function in people with congestive heart failure. About 45 adults with mild to moderate heart failure will be randomly assigned to receive one of the supplements o…

This study tests whether a device called transcutaneous auricular vagus nerve stimulation (TaVNS) can reduce anxiety and distress in healthcare workers. Participants wear special earbuds that send gentle vibrations to stimulate the vagus nerve. Researchers will also use brain sca…

This study tests whether N-acetyl cysteine (NAC), a common antioxidant supplement, can improve brain function and reduce inflammation in people with multiple sclerosis (MS). Researchers will use brain scans to measure changes in metabolism and inflammation. The study enrolls 55 a…

This pilot study compares three pain relief methods for people with three or more broken ribs on one side. Participants will receive either a nerve block with a numbing medicine, a lidocaine infusion, or standard pain care. The goal is to see which approach reduces opioid use and…

This study looks at what helps or hinders people from getting screened for colorectal cancer, focusing on African American, Latinx, and Chinese communities. Researchers will conduct interviews and focus groups to understand cultural beliefs and knowledge gaps. The goal is to crea…

This study was designed to track sleep quality in people with head and neck cancer undergoing surgery. Researchers planned to measure factors like time to fall asleep and nighttime awakenings to understand how treatment impacts sleep. The study was withdrawn before enrolling any …