Thomas Jefferson University

This phase II trial tests whether combining two hormone-blocking drugs — onapristone and anastrozole — can shrink tumors or slow cancer growth in women with hormone-receptor-positive endometrial cancer that has not responded to prior chemotherapy. Onapristone blocks progesterone …

This study tested a three-drug combination (navitoclax, venetoclax, and decitabine) in 6 adults with high-risk myelodysplastic syndrome (MDS) that came back or didn't respond to standard therapy. The goal was to find the safest dose and see if the combo could shrink or control th…

This study tested a new way to make radiation therapy more effective for people with liver cancer. Doctors used special ultrasound contrast agents (tiny gas-filled microbubbles) and then 'popped' them with ultrasound waves to make tumors more sensitive to radiation. The study inv…

This study tested a treatment for uveal melanoma that has spread to the liver. Tiny radioactive beads were injected into the liver's blood vessels to deliver radiation directly to tumors. The goal was to shrink or control the liver tumors. 48 patients took part, and the study loo…

This study tested whether providing medically tailored meals and nutrition counseling via telehealth can improve blood sugar control in adults with poorly controlled type 2 diabetes. 600 participants were randomly assigned to receive meals, meals plus counseling, or usual care. T…

This study tested an enhanced tobacco intervention program (ETIP) for people with head and neck or lung cancer who smoke. The program combined counseling, nicotine replacement, and medications like bupropion or varenicline. Nineteen participants were enrolled to see if the progra…

This study tests whether whole exome and whole genome sequencing can uncover genetic causes of nonimmune fetal hydrops—a serious condition where fluid builds up in a fetus—when standard tests find nothing. Researchers will analyze DNA from 55 affected fetuses or newborns and thei…

This study tested whether contrast-enhanced ultrasound (CEUS) can estimate the pressure inside breast tumors without using a needle. Twenty-five women scheduled for breast biopsy received an IV contrast agent and underwent ultrasound imaging. The goal was to see if the ultrasound…

This study compares two types of ultrasound for monitoring women who have had breast reconstruction after cancer. One is the standard handheld ultrasound, the other is an automated machine that scans the breast. The goal is to see if the automated version can detect leftover brea…

This study looked at whether a special ultrasound using gas microbubbles can predict how well bile duct cancer responds to targeted radiotherapy. The ultrasound can also pop these bubbles, which might make the cancer easier to treat. Sixteen adults with bile duct cancer took part…

This study tested a noninvasive ultrasound technique called SHAPE to measure pressure inside the skull. Nineteen adults scheduled for a lumbar puncture received an ultrasound contrast agent (Definity) while researchers compared the ultrasound readings to the standard needle-based…

This study tested a vacuum dressing called PREVENA on 272 adults who had a leg amputated. The dressing applies gentle suction over the surgical cut to help it heal and prevent complications like infection, reopening, or fluid buildup. The goal was to see if this device reduces wo…

This study tested two forms of progesterone—vaginal gel and a shot—to see which works better at preventing another preterm birth in women who had one before. About 210 pregnant women with a prior preterm birth took part. The goal was to find out if the vaginal option is more effe…

This study tested a device called Prevena, a sterile sponge that applies gentle suction to a closed surgical wound for 5-7 days after groin surgery. The goal was to see if it lowers the chance of wound infections, reopening, or fluid leaks compared to a standard dry gauze dressin…

This study looked at how aspirin affects platelet function in 130 pregnant women at high risk for preeclampsia. Researchers measured platelet response and genetic factors to see if they could predict who develops high blood pressure disorders. The goal is to eventually personaliz…

This small pilot study tested a 3-month program where men with prostate cancer on hormone therapy were encouraged to fast for 12 to 16 hours each night, supported by weekly coaching calls and text messages. The 40 participants found the program feasible and satisfying, with some …

This study tested whether using telehealth visits and smart pill bottles can help breast cancer patients take their hormone therapy as prescribed. 305 women and men with early-stage hormone receptor-positive breast cancer participated. They either had regular in-person checkups o…

This study looked at whether nutritional supplements, specifically N-acetyl cysteine (NAC) given orally and intravenously, could support brain function in people with Parkinson's disease. The researchers measured dopamine activity and markers of inflammation in the brain using sp…

This pilot study tested whether a mindfulness program could help prevent chemo-brain in women about to start chemotherapy for breast cancer. Fifteen women participated in mindfulness sessions and underwent brain scans and blood tests. The main goal was to see if women would stick…

This study tested whether giving Darzalex Faspro (a drug for multiple myeloma) at home is practical and satisfactory for patients. Twenty adults with multiple myeloma who were already on a monthly daratumumab regimen received their injections at home. The main goal was to measure…

This study tested a personalized home exercise program for women with metastatic breast cancer who were not very active. The program was designed by a cancer exercise specialist to fit each patient's needs and abilities. The goal was to see if it could help them become more physi…

This study looks at whether a web-based virtual genetics board helps doctors discuss and manage prostate cancer genetics. About 118 healthcare providers, including oncologists and genetic counselors, will use the board and then give feedback through surveys and interviews. The go…

This study used a special 3D ultrasound technique (called 3D transesophageal echocardiography) to measure how well the right side of the heart works in 67 adults who had one of three types of aortic valve replacement. The goal was to see if this method can reliably track changes …

This study tested a group well child care program for mothers in treatment for opioid use disorder and their infants. Instead of standard one-on-one checkups, mother-infant pairs attended group visits together from 1 to 18 months of age. The goal was to see if this approach impro…

This study looked at how factors like chronic stress and depression might speed up liver damage in Korean Americans with chronic hepatitis B. Researchers followed 365 participants over time, collecting health records, hair samples, and interview data. The goal was to understand w…

This completed study from Thomas Jefferson University involved 20 adults with thyroid eye disease and their caregivers. Researchers conducted focus groups and interviews to understand how the condition affects mood, relationships, work, and daily life. Participants also completed…

This study looked at leftover tumor tissue and blood samples from 141 adults with glioblastoma or other solid tumors who were having surgery. The goal was to measure cell counts and viability to help scientists design better treatments for brain cancer and other solid tumors in t…

This study looked at 78 adults who had heart surgery and needed a breathing tube while being moved to the intensive care unit. Researchers compared using a manual bag (AMBU bag) versus a mechanical ventilator (Hamilton C1) to see which method kept blood pressure and oxygen levels…

This study tested whether a peer-led health education program could help African American men better understand genetic testing for prostate cancer. 149 men with or without a personal or family history of prostate cancer took part. The program aimed to reduce confusion and improv…

This study tested a mobile-friendly web tool that educates men with prostate cancer about genetic testing. Researchers compared traditional genetic counseling with the online tool to see if it helps patients decide whether to get tested. The study involved 346 men with advanced o…

This completed study followed 150 pregnant or breastfeeding women who received a bivalent COVID-19 booster. Researchers measured antibody levels in mothers, infants, and breast milk to understand how vaccination impacts immunity against COVID-19 variants. The goal was to learn mo…

This completed study followed 105 pregnant women who had COVID-19 or received a COVID-19 vaccine. Researchers measured antibodies in the mothers' blood and breast milk, as well as in the umbilical cord blood at delivery, to see how immunity transfers to the baby. The goal was to …

This study looked at how the body processes ropivacaine, a numbing medicine, when given as a nerve block for chest surgery. Twenty adults having robotic or video-assisted chest surgery received the block, and researchers measured drug levels in their blood to check for toxicity. …