Thomas Jefferson University

This is an early-stage safety study testing a new two-part cancer vaccine strategy. It is for adults with advanced colorectal or small bowel cancer that has continued to grow despite standard treatments. The main goal is to find a safe dose and see if the body's immune system rea…

This study is testing if giving the drug ketamine earlier, along with another sedative, can stop severe, drug-resistant seizures faster. It will involve 50 hospitalized adults whose seizures are not responding to standard medications. The main goal is to see if changing the timin…

This study is testing whether a targeted course of radiation therapy can provide lasting relief for people with moderate to severe hidradenitis suppurativa (HS) that hasn't responded well to other treatments. Ten adult participants with HS in both armpits will receive radiation t…

This study is testing a new combination of two drugs, pacritinib and azacitidine, for people with a type of blood and bone marrow cancer called myelodysplastic syndrome (MDS). The first part of the study will find the safest dose. The second part will see if this dose helps contr…

This study is testing whether a personalized physical therapy program helps people recover better after surgery to repair a belly (ventral) hernia. Researchers will compare 100 patients who get the special therapy to those who receive standard post-surgery instructions. The goal …

This study aims to see if a new, enhanced ultrasound technique is as good as the current standard MRI for finding serious prostate cancer during a biopsy. 300 men scheduled for a prostate biopsy will receive both the new ultrasound scan and a standard MRI to compare how well each…

This small, early-stage study is testing whether a special type of ultrasound scan, called contrast-enhanced ultrasound (CEUS), can help doctors better monitor how soft tissue sarcoma responds to radiation treatment given before surgery. The study will enroll about 10 adults with…