Thomas Jefferson University

This phase 2 trial is testing an experimental drug called xaluritamig in men with metastatic castrate-resistant prostate cancer who had only a partial or stable response to lutetium-177 therapy. The goal is to see if xaluritamig can shrink tumors or lower PSA levels. About 30 par…

This study tests a new two-drug combination (pacritinib plus azacitidine) for people with moderate to very high risk myelodysplastic syndrome (MDS), a bone marrow disorder. The first part finds the safest dose of pacritinib, and the second part checks how well the combination wor…

After lung surgery, some patients have a persistent air leak that requires a chest tube for days. This study tests whether injecting a sugar water solution (dextrose) through the tube can seal the leak faster than standard drainage alone. About 80 adults with a stubborn air leak …

This study tests whether giving the drug ketamine earlier, along with midazolam, can stop prolonged seizures faster in adults. Researchers will compare early versus late ketamine timing in 50 patients with refractory status epilepticus. The goal is to see if earlier use shortens …

This study compares a special ultrasound (mp-US) with contrast dye to standard MRI for finding prostate cancer. About 300 men scheduled for a biopsy will get both scans to see if the ultrasound can guide biopsies just as well as MRI. The goal is to offer a simpler, cheaper option…

This study tests whether a personalized physical therapy program helps people recover better after ventral hernia repair compared to standard care. One hundred adults aged 18-75 will be randomly assigned to either tailored PT or usual post-op instructions. Researchers will measur…

This study tests a program called BEST4Baby, which uses trained peer counselors and a mobile health app to support new mothers in India with breastfeeding. About 336 pregnant women will be split into two groups: one gets the extra support, the other gets usual care. Researchers w…

This study tests a program called Improving Dementia Care (IDC) to help primary care doctors identify dementia in patients who have memory concerns but no prior diagnosis. About 80 adults with mild cognitive issues will take part. The goal is to see if the program leads to more d…