Thomas Jefferson University

This trial tests whether time-restricted eating (TRE) — a 16:8 fasting schedule — is feasible for patients with HER2-negative breast cancer undergoing neoadjuvant chemotherapy. Participants will follow TRE for 16 weeks while receiving chemo, and researchers will measure how many …

This study tests a new way to treat infected knee replacements. About 100 adults having surgery for an infected knee will be randomly assigned to receive either standard care or standard care plus an extra treatment. The extra treatment involves injecting antibiotics along with s…

This study tests a drug called tebentafusp combined with treatments directed at the liver (like embolization or chemo-embolization) for people with a rare eye cancer (uveal melanoma) that has spread to the liver. About 109 adults with a specific immune type (HLA-A*0201) will part…

This study tests a drug called tebentafusp in 19 people with a rare eye cancer (uveal melanoma) that is too large to remove without taking the whole eye. The goal is to see if the drug can shrink the tumor by at least 20% so that less invasive surgery might be possible. Participa…

This study tests whether placing a stitch (cerclage) in the cervix can lower the chance of preterm birth in pregnant people with a short cervix (≤25mm) detected between 24-26 weeks. About 329 participants will be randomly assigned to receive the stitch or standard care. The main …

This study tests whether high-dose radiotherapy can improve symptoms of hidradenitis suppurativa, a painful skin condition. Ten adults with moderate to severe disease will receive radiation to one armpit while the other armpit gets standard care. Researchers will compare changes …

This early-phase trial tests a two-step vaccine strategy in adults with advanced colorectal or small bowel cancer that has stopped responding to standard treatments. Participants first receive one vaccine injection, followed by two doses of a second vaccine four weeks apart. The …

This early study tests whether using ultrasound and microbubbles can help the immunotherapy drug pembrolizumab (Keytruda) work better in people with head and neck cancer that has come back or spread. Only 6 participants will receive three rounds of treatment. The main goal is to …

This early-phase trial tests two different drug combinations for people whose acute myeloid leukemia (AML) has returned or not responded to prior treatment. In Part 1, participants receive tazemetostat plus a standard chemotherapy called CPX-351. In Part 2, they get palbociclib b…

This study tests two non-invasive techniques to improve breathing in people with chronic spinal cord injury. Participants will receive spinal cord stimulation and breathe special air mixtures to strengthen breathing muscles. The study involves 20 adults with incomplete spinal cor…

This study is testing whether adding calorie restriction to a precise, high-dose radiation treatment (SABR) before surgery can shrink breast tumors more than radiation alone. About 80 adults with early-stage breast cancer will be randomly assigned to either standard dietary advic…

This study tests whether giving iron through a vein (IV) early in the second trimester works better than iron pills for treating anemia in pregnancy. About 80 pregnant women with mild iron deficiency will be randomly assigned to one of the two treatments. The goal is to see which…

This study tests a new approach to collect stem cells for transplant in people with multiple myeloma, Hodgkin lymphoma, or non-Hodgkin lymphoma. Instead of giving everyone the drug plerixafor, doctors will start with G-CSF alone and only add plerixafor if needed. The goal is to s…

This phase 2 trial tests a two-step, lower-intensity transplant method for people with various blood cancers. The goal is to see if this gentler approach reduces the chance of dying from the transplant itself. About 63 participants will receive a combination of radiation, chemoth…

This study tests whether a continuous glucose monitor (CGM) helps pregnant women with type 2 diabetes track their blood sugar better than traditional finger-stick testing. Seventy participants will be randomly assigned to use either a CGM or a glucometer from enrollment until del…

This study explores whether women can accurately collect their own samples for HPV testing, which could make cervical cancer screening easier and more accessible. The research focuses on minority women who are often under-screened, using community health workers to help with the …

This study tests whether contrast-enhanced ultrasound (CEUS) can better detect if liver cancer (HCC) has been killed by radioembolization treatment. Standard CT or MRI scans often take months to show clear results, delaying further treatment. Researchers will enroll 30 patients a…

This pilot trial tests whether a 12-week virtual tai chi program can reduce joint pain in postmenopausal women with hormone receptor-positive breast cancer who are taking aromatase inhibitors. Participants are randomly assigned to tai chi classes or health education sessions. The…

This study looks at whether adding cognitive behavioral therapy (CBT) to standard education helps people who take opioids for chronic pain taper off them before spine surgery. About 45 adults scheduled for major spine surgery at least four weeks ahead will be split into two group…

This study tests whether a self-help version of Acceptance and Commitment Therapy (ACT), delivered via smartphone, can reduce anxiety and depression in adults with cystic fibrosis. About 60 participants will use the toolkit and report their symptoms. The goal is to improve mental…

This study looks at whether placing a small tube (stent) in the urinary tract after bladder removal surgery affects recovery. About 70 adults with bladder or pelvic cancers will be randomly assigned to get a stent or not. The main goal is to see if avoiding stents lowers the risk…

This study tests whether giving blood transfusions at home is practical and acceptable for cancer patients who need regular transfusions. About 30 adults with blood cancers or bone marrow failure will receive 1-5 blood product units at home. Researchers will track how often trans…

This study compares two schedules for taking non-opioid pain relievers (acetaminophen and NSAIDs) after a cesarean delivery: taking them at different times (staggered) or at the same time (simultaneous). The goal is to see which approach better controls pain and reduces the need …

This study looks at how to help cancer patients from low-income and low-literacy backgrounds take their oral chemotherapy pills correctly. Researchers will test different support strategies to see which ones work best. The goal is to reduce missed doses and improve overall care f…

This study tests whether a network of peer genetic coaches can help African American men with metastatic prostate cancer overcome barriers to genetic testing. The coaches are trained to provide education, address concerns, and guide men through the testing process. The goal is to…

SPIDER is a worldwide registry collecting data from 1,000 patients with a rare spinal blood vessel condition called spinal dural arteriovenous fistula. By pooling information from many hospitals, researchers hope to learn which treatments—surgery or endovascular procedures—work b…

This small pilot study is testing whether contrast-enhanced ultrasound (CEUS) can help doctors monitor how soft tissue sarcoma responds to radiation therapy. Ten adults scheduled for radiation will get CEUS scans before, during, and after treatment. The goal is to see if CEUS ima…

This study looks at whether having a trained peer navigator—someone who guides patients through the process—helps African American men with advanced prostate cancer better understand and complete genetic testing. Genetic testing is important for treatment decisions, but many pati…

This pilot study looks at how social determinants of health—like housing, food, and transportation—relate to inflammation in women newly diagnosed with breast cancer. Participants fill out surveys and give a blood sample at a single visit. The goal is to understand these connecti…

This study explores whether virtual reality and 3D models can help surgeons plan head and neck cancer operations more accurately. About 160 adults with head and neck cancer will take part. The goal is to see if this technology reduces the chance of leftover cancer cells and impro…

This study looks at why cancer patients who have needs like help with transportation, food, or housing choose not to accept support services. Researchers will survey 500 adults and interview a smaller group to understand their reasons. The goal is to improve how hospitals offer h…

This observational pilot study at Thomas Jefferson University will enroll 20 adults with cardiogenic shock who are already receiving an intra-aortic balloon pump (IABC). Researchers will measure baseline arterial compliance (how stiff the arteries are) and then track heart functi…

This study looks at whether PET/CT scans can detect heart damage caused by radiation therapy in people with lung or esophageal cancer. About 20 participants will get special heart scans before, during, and after their radiation treatment. The goal is to see if the scans can pick …

This trial compares two standard surgical techniques for early-stage lung cancer: tying off the pulmonary vein first versus the pulmonary artery first. Researchers want to see which method better reduces circulating tumor DNA (ctDNA) in the blood after surgery, as lower ctDNA may…

This study collects tissue, blood, and optional rectal swabs from 200 adults with breast cancer or carcinoma in situ. Samples are taken during standard procedures like surgery. Researchers will analyze them to identify tumor biomarkers and genetic profiles, aiming to better under…

This study tests whether a 14-day mobile diary is a practical way to measure daily stress and thinking (cognitive) changes in breast cancer survivors. Researchers will enroll 30 racially diverse women aged 40 and older who are at least five years past diagnosis. Participants comp…