Magic mushroom compound tested for depression in lung cancer patients

NCT ID NCT07216404

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether psilocybin (the active ingredient in magic mushrooms) combined with therapy is safe and helpful for people with non-small cell lung cancer who also have major depression. Ten participants will receive psilocybin in a controlled setting along with counseling sessions. The goal is to see if this approach can reduce depression symptoms and improve well-being without serious side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
psilocybin
What this could lead to
If it works, this could point toward a new way to ease severe depression in people with lung cancer, improving their quality of life.
What could go wrong
This is a very small, early-phase trial with only 10 participants, so results may not apply broadly. Psilocybin can cause hallucinations and emotional distress, and safety is still being checked.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Ohio State University Comprehensive Cancer Center

    RECRUITING

    Columbus, Ohio, 43210, United States

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