New radiation technique could boost immunotherapy in advanced lung cancer

NCT ID NCT06660407

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial at Mayo Clinic is testing a special type of radiation called grid therapy combined with standard immunotherapy for people with stage IV non-small cell lung cancer that has stopped responding to treatment. Grid therapy delivers high doses of radiation to small areas of the tumor, which may help kill cancer cells more effectively. The study will enroll 20 adults to see if this combination is safe and can shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
grid radiation therapy
What this could lead to
If it works, this could offer a new treatment option for advanced lung cancer patients whose disease has worsened despite immunotherapy.
What could go wrong
This is a small early-phase trial with only 20 participants, so results may not apply broadly. There is also a risk of serious side effects from the radiation and immunotherapy combination.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Mayo Clinic in Rochester

    RECRUITING

    Rochester, Minnesota, 55905, United States

    Contact Email: •••••@•••••

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