LUNG NON-SMALL CELL CARCINOMA

This phase II trial tests a shorter, higher-dose radiation therapy followed by the immunotherapy drug atezolizumab in 47 patients with stage II or III non-small cell lung cancer who have borderline health. The goal is to see if this approach is safe and effective for people who c…

This study is for people with non-small cell lung cancer who have had chemotherapy and surgery. It tests whether adding a drug called AZD6738 to the immunotherapy drug durvalumab can help keep the cancer from coming back longer than durvalumab alone. About 630 adults with stage I…

This study is for people with advanced non-small cell lung cancer that does not have the PD-L1 marker, making it harder to treat with immunotherapy alone. The trial compares standard immunotherapy (with or without chemotherapy) to the same treatment plus radiation therapy. The go…

This phase 3 trial tests whether adding the immunotherapy drug atezolizumab to standard radiation therapy (SBRT) helps people with early-stage non-small cell lung cancer live longer. About 415 participants with high-risk stage I-IIA lung cancer will receive either SBRT alone or S…

This study tests whether giving the immunotherapy drug pembrolizumab every 12 weeks works as well as the standard every 3 weeks in people with non-small cell lung cancer who are already benefiting from the drug. The goal is to see if fewer treatments can keep the cancer under con…

This study compares two standard treatments for lung tumors: microwave ablation, which uses heat to kill cancer cells, and surgical wedge resection, which removes a small piece of lung. Researchers want to see which method works better and is safer for patients with non-small cel…

This study looks at whether adding surgery or radiation to the targeted drug osimertinib helps people with advanced EGFR-mutant non-small cell lung cancer live longer without their cancer growing. About 173 participants will receive either osimertinib alone or osimertinib plus lo…

This phase II trial tests a DNA vaccine called STEMVAC in 5 people with stage IV non-small cell lung cancer. The vaccine gives the body instructions to make parts of five proteins found on lung cancer cells, with the goal of activating immune cells to attack the tumor. Participan…

This study tests whether adding local treatments like surgery or radiation to a combination of two immunotherapy drugs (nivolumab and ipilimumab) helps people with stage IV non-small cell lung cancer live longer compared to immunotherapy alone. About 339 participants who have not…

This early-phase trial tests whether combining two immunotherapy drugs (ipilimumab and nivolumab) with radiation therapy is safe and effective for patients with stage II or III non-small cell lung cancer that cannot be surgically removed. The study enrolls 21 participants who hav…

This early-phase trial tests whether adding a drug called papaverine to precise, high-dose radiation (SBRT) can help control non-small cell lung cancer. About 19 patients with a single lung tumor will receive both treatments. The main goal is to find the safest dose and see if th…

This study tests whether a lung cancer drug called atezolizumab can be safely given as a shot under the skin at home, with doctors monitoring patients through video calls. It involves 5 adults with non-small cell lung cancer. The goal is to see if this home-based approach is prac…

This study compares two medications, infliximab and vedolizumab, to treat colitis (colon inflammation) caused by immune checkpoint inhibitor therapy in cancer patients. About 47 adults with genitourinary cancer, melanoma, or non-small cell lung cancer are participating. The goal …

This study tests a drug called AMG 510 in people with advanced lung cancer that has a specific genetic change (KRAS G12C mutation). The drug is designed to block the cancer's growth signal. About 116 participants will receive the treatment to see if it can shrink tumors and slow …

This study combines the CIMAvax EGF vaccine with immunotherapy drugs (nivolumab or pembrolizumab) to treat advanced non-small cell lung cancer and squamous head and neck cancer. The vaccine aims to slow tumor growth, while the immunotherapy helps the immune system attack cancer c…

This early-phase trial is testing whether adding local treatments like surgery or radiation to the targeted drug brigatinib can help control advanced ALK-positive non-small cell lung cancer. About 35 people who have not yet taken other targeted therapies will receive brigatinib f…

This early-stage study tests whether giving a single, very focused dose of radiation after lung cancer surgery is safe and causes fewer side effects than standard weeks-long radiation. It involves 50 adults with non-small cell lung cancer who had surgery but still have cancer cel…

This study tests whether anamorelin, a drug that stimulates appetite, can help advanced lung cancer patients who have lost their appetite and weight. Researchers will interview 25 patients and compare those taking the drug to those taking a placebo. The goal is to see if the drug…

This phase III trial is testing whether a telehealth self-management program can improve care coordination and quality of life for survivors of non-small cell lung cancer or colorectal cancer. About 403 participants who finished treatment 4 months ago will receive coaching sessio…

This study tests a conversation tool designed to help people with lung cancer understand their options and make decisions that match their values. About 98 patients will use the tool during their care. The goal is to see if it reduces anxiety, regret, and confusion, and improves …

This study aims to find out why some cancer patients develop nerve damage (tingling or numbness in hands and feet) from taxane chemotherapy. Researchers will track over 1,300 people with breast, lung, or ovarian cancer to see how age, gender, and other factors affect their risk. …

This study collects tissue and blood samples from 1,600 people with various advanced cancers, along with their medical information, over the course of their treatment. Researchers will store these samples and data in a biobank for current and future studies. The goal is to better…

This study looks for early signs of heart damage in people getting radiation therapy for lung or esophageal cancer. Researchers use heart scans and blood tests to see if changes happen during or shortly after treatment. The goal is to find patients at risk and help make future ca…