LUNG NON-SMALL CELL CARCINOMA

This study tests whether adding an immunotherapy drug (atezolizumab) to standard radiation therapy helps people with early-stage non-small cell lung cancer live longer. About 480 participants with stage I-IIA lung cancer will receive either radiation alone or radiation plus atezo…

This study looks at whether adding radiation therapy to standard immunotherapy (with or without chemotherapy) can help people with advanced non-small cell lung cancer that is PD-L1 negative. About 427 participants with stage IIIB to IV lung cancer will be randomly assigned to rec…

This phase 3 trial studies whether adding local treatments like surgery or radiation to immunotherapy (nivolumab and ipilimumab) helps people with stage IV non-small cell lung cancer live longer. About 339 participants will receive immunotherapy alone or with additional local the…

This study compares two medications, infliximab and vedolizumab, for treating colitis (colon inflammation) caused by immune checkpoint inhibitor therapy in cancer patients. About 47 adults with genitourinary cancer, melanoma, or non-small cell lung cancer will receive one of thes…

This study tests whether adding a drug called AZD6738 to the immunotherapy durvalumab can help keep lung cancer from returning in patients who have already had chemotherapy and surgery. About 630 adults with stage II to IIIB non-small cell lung cancer will take part. The goal is …

This study compares two treatments for lung lesions in people with non-small cell lung cancer, sarcoma, or colorectal cancer that has spread. One treatment uses microwave energy to heat and kill tumor cells, while the other is a small surgery to remove the tumor. Researchers want…

This study is for people with stage II or III non-small cell lung cancer who are not healthy enough for standard treatments. It tests a shorter, stronger course of radiation followed by the immunotherapy drug atezolizumab. The goal is to see if this combination is safe and helps …

This study looks at whether adding surgery or radiation to the targeted therapy osimertinib can help people with advanced EGFR-mutant non-small cell lung cancer live longer without the disease getting worse. About 173 participants with stage IIIB or IV lung cancer will be randoml…

This early-phase trial tests whether adding papaverine, a drug that may make cancer cells more sensitive to radiation, can safely improve treatment for non-small cell lung cancer. About 19 adults with tumors 5 cm or smaller will receive stereotactic body radiation therapy (SBRT) …

This study tests a combination of the CIMAvax vaccine (which targets a protein that helps tumors grow) and nivolumab (an immunotherapy that boosts the immune system) in people with advanced non-small cell lung cancer or squamous head and neck cancer. The goal is to find the best …

This early trial tested a two-pronged approach for people with advanced ALK-positive non-small cell lung cancer. Participants first received a targeted drug (brigatinib), then local treatments like surgery or radiation to any remaining tumors. The goal was to see if this combinat…

This early-phase trial tests whether combining two immunotherapy drugs (ipilimumab and nivolumab) with radiation therapy is safe and effective for people with stage II or III non-small cell lung cancer that cannot be removed by surgery. The study includes 21 participants and aims…

This study tests a DNA vaccine called STEMVAC in people with stage IV non-small cell lung cancer. The vaccine teaches the immune system to recognize and attack cancer cells. It is given alongside standard maintenance therapy to see if it can shrink tumors and improve outcomes.

This study tests whether a lung cancer drug called atezolizumab can be safely given at home by a nurse, with doctor visits done by video call. It involves 5 adults with non-small cell lung cancer. The goal is to see if this home-based approach is practical and safe.

This study tests a drug called AMG 510 in people with advanced lung cancer that has a specific genetic change (KRAS G12C). The drug targets this change to stop cancer growth. About 116 participants will receive the treatment to see if it shrinks tumors and how safe it is.

This early-stage trial looks at whether giving one very precise, high-dose radiation treatment after lung cancer surgery is safe and causes fewer side effects than the usual weeks of daily radiation. About 50 adults with non-small cell lung cancer who had surgery but still have s…

This study tests a telehealth self-management program for people who have finished treatment for early-stage lung or colorectal cancer. The program coaches survivors on follow-up care, communication with doctors, and managing their health. Researchers want to see if it improves c…

This study looks at whether a drug called anamorelin can help improve appetite and stop weight loss in people with advanced non-small cell lung cancer who have lost their appetite. About 25 participants will take either the drug or a placebo and share their experiences through in…

This study follows over 1,300 people with breast, lung, or ovarian cancer who are starting a type of chemotherapy called taxane. The goal is to find out which patients are more likely to develop nerve damage (peripheral neuropathy), which can cause tingling or numbness in the han…

This study tests a conversation aid designed to help people with lung cancer and their doctors make treatment decisions together. About 98 patients will use the tool to see if it reduces anxiety and regret while improving understanding. The goal is to make decision-making easier …

This study collects tissue and blood samples, along with medical information, from 1,600 people with various advanced cancers. Researchers will store and study these samples over time to learn how cancer changes and why some treatments stop working. The goal is to improve future …

This study looks for early signs of heart injury in people receiving radiation therapy for lung or esophageal cancer. Researchers use heart scans and blood tests to detect changes during or shortly after treatment. The goal is to identify patients at risk for heart problems and i…