New combo attack on lung cancer: targeted drug plus surgery or radiation
NCT ID NCT03707938
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing whether adding local treatments like surgery or radiation to the targeted drug brigatinib can help control advanced ALK-positive non-small cell lung cancer. About 35 people who have not yet taken other targeted therapies will receive brigatinib followed by local therapy to any remaining tumor spots. The main goal is to check safety, but researchers will also track how long the cancer stays under control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- brigatinib (a targeted drug) plus local consolidative therapy (surgery or radiation)
- What this could lead to
- If it works, this could point toward a way to better control advanced ALK-positive lung cancer by combining targeted drug therapy with local treatments like surgery or radiation.
- What could go wrong
- This is a very early (Phase 1) pilot trial with only 35 participants, so results may not apply broadly. The main goal is safety, not yet proof of effectiveness, and side effects from both treatments are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
Houston, Texas, 77030, United States
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