Alliance For Clinical Trials In Oncology

This study is testing if adding a new targeted drug, vorasidenib, to the usual treatment (radiation and chemotherapy) works better for people with a specific type of newly diagnosed brain tumor called grade 3 astrocytoma. About 408 patients will receive either the new drug combin…

This study is testing whether adding a precise form of radiation therapy after lung cancer surgery helps prevent the cancer from coming back. It will involve 164 adults who had surgery but still have cancer in nearby lymph nodes. Participants will be randomly assigned to receive …

This study is testing a new approach for giving a targeted radiation drug to men with advanced prostate cancer that has stopped responding to hormone therapy. It will compare the standard schedule of six doses given every six weeks to a new approach where, after two successful do…

This study is for older adults (65+) with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). It compares a new, time-limited combination of two oral drugs (zanubrutinib and sonrotoclax) against taking one of the drugs continuously. The main goal is …

This study is testing whether a gentle laser treatment can help reduce vaginal dryness and discomfort in women who have survived breast cancer. The dryness is often a side effect of cancer treatments or menopause. About 250 participants will be randomly assigned to receive either…

This study aims to find the best way to inform close family members of a colorectal cancer patient about their potential inherited risk for cancer. It will compare if a doctor contacting relatives directly is more effective than having the patient share the news themselves. The g…