Alliance For Clinical Trials In Oncology

This study compares a fixed-duration combination of two drugs (zanubrutinib and sonrotoclax) against continuous zanubrutinib alone in older adults with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. The goal is to see if the combination improves how long pa…

This study tests whether adding a precise type of radiation therapy (I²-PORT) after lung cancer surgery can lower the chance of cancer coming back. It is for people with non-small cell lung cancer who still have cancer in their lymph nodes after chemotherapy or immunotherapy befo…

This study tests whether adding a targeted drug called vorasidenib to standard treatment (radiation and chemotherapy) can help people with a specific type of brain tumor (grade 3 astrocytoma with IDH mutation). About 408 participants will receive either vorasidenib or a placebo a…

This phase 3 trial tests whether giving the prostate cancer drug lutetium-177 PSMA less often, based on how the cancer responds, can improve quality of life without shortening survival. The study involves 1,524 men with advanced, hormone-resistant prostate cancer that has spread.…

This study looks at the best way to inform close relatives (parents, siblings, children) of people newly diagnosed with colorectal cancer about their possible genetic risk. Some families will have a doctor or healthcare provider reach out to relatives directly, while others will …