Alliance For Clinical Trials In Oncology

This study tested a combination of chemotherapy drugs in 318 adolescents and young adults (ages not specified but typical for this group) with newly diagnosed acute lymphoblastic leukemia (ALL). The goal was to see how well the treatment worked at killing cancer cells and stoppin…

This study tested whether giving the drug bortezomib after intensive chemotherapy, antibody therapy, and a stem cell transplant could help keep mantle cell lymphoma from coming back. 151 adults with untreated mantle cell lymphoma took part. The goal was to see if this approach im…

This study compared two types of surgery for people with small (≤2 cm) early-stage lung cancer: removing the entire lobe (lobectomy) versus removing only the tumor and a small margin (sublobar resection). The goal was to see if the less invasive approach works just as well with f…

This study looked at how well older adults (70+) with a common type of advanced breast cancer tolerate a combination of the targeted drug palbociclib and hormone therapy (letrozole or fulvestrant). The goal was to understand side effects and find factors beyond age that might pre…

This study tested a combination of two drugs, sorafenib and bevacizumab, in 83 people with advanced colorectal cancer that had spread and stopped responding to standard treatments. The goal was to see if the combination could slow or stop tumor growth. Participants received both …

This study looked at whether adding a breast MRI before surgery helps women with early-stage breast cancer have better results. About 317 women with certain types of breast cancer took part. The goal was to see if the MRI helps doctors choose the best surgery and reduce the need …