New drug combo may keep rare lymphoma at bay after transplant

NCT ID NCT00310037

Completed Disease control Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether giving the drug bortezomib after intensive chemotherapy, immunotherapy, and a stem cell transplant can help prevent mantle cell lymphoma from coming back. 151 patients were randomly assigned to receive bortezomib either as maintenance (long-term) or consolidation (short-term) therapy. The goal was to see how many patients remained cancer-free 18 months after treatment. Results suggest this approach may improve outcomes, but more research is needed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

bortezomib

What this could lead to

If successful, this approach could help keep mantle cell lymphoma from coming back after intensive treatment, potentially extending the time patients live without their cancer progressing.

What could go wrong

This is a phase 2 trial with a moderate number of participants, so results are not definitive. Bortezomib can cause side effects like nerve damage, fatigue, and low blood counts, and it may not work for everyone.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

mantle cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MANTLE CELL LYMPHOMA

Contacts and locations

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Locations

Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210-1240, United States
BroMenn Regional Medical Center

Normal, Illinois, 61761, United States
CCOP - Illinois Oncology Research Association

Peoria, Illinois, 61615, United States
CCOP - North Shore University Hospital

Manhasset, New York, 11030, United States
Community Cancer Center

Normal, Illinois, 61761, United States
Community Hospital of Ottawa

Ottawa, Illinois, 61350, United States
Dana-Farber/Brigham and Women's Cancer Center

Boston, Massachusetts, 02115, United States
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute

Boston, Massachusetts, 02115, United States
Don Monti Comprehensive Cancer Center at North Shore University Hospital

Manhasset, New York, 11030, United States
Eureka Community Hospital

Eureka, Illinois, 61530, United States
Galesburg Clinic, PC

Galesburg, Illinois, 61401, United States
Graham Hospital

Canton, Illinois, 61520, United States
Illinois CancerCare - Bloomington

Bloomington, Illinois, 61701, United States
Illinois CancerCare - Canton

Canton, Illinois, 61520, United States
Illinois CancerCare - Carthage

Carthage, Illinois, 62321, United States
Illinois CancerCare - Community Cancer Center

Normal, Illinois, 61761, United States
Illinois CancerCare - Eureka

Eureka, Illinois, 61530, United States
Illinois CancerCare - Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare - Havana

Havana, Illinois, 62644, United States
Illinois CancerCare - Kewanee Clinic

Kewanee, Illinois, 61443, United States
Illinois CancerCare - Macomb

Macomb, Illinois, 61455, United States
Illinois CancerCare - Monmouth

Monmouth, Illinois, 61462, United States
Illinois CancerCare - Pekin

Pekin, Illinois, 61603, United States
Illinois CancerCare - Peru

Peru, Illinois, 61354, United States
Illinois CancerCare - Princeton

Princeton, Illinois, 61356, United States
Illinois CancerCare - Spring Valley

Spring Valley, Illinois, 61362, United States
Illinois Valley Community Hospital

Peru, Illinois, 61354, United States
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill

Chapel Hill, North Carolina, 27599-7295, United States
Long Island Jewish Medical Center

New Hyde Park, New York, 11040, United States
Mason District Hospital

Havana, Illinois, 62644, United States
McDonough District Hospital

Macomb, Illinois, 61455, United States
Memorial Hospital

Carthage, Illinois, 62321, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States
Monter Cancer Center of the North Shore-LIJ Health System

Lake Success, New York, 11042, United States
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756-0002, United States
OSF Holy Family Medical Center

Monmouth, Illinois, 61462, United States
OSF St. Francis Medical Center

Peoria, Illinois, 61637, United States
Oncology Hematology Associates of Central Illinois, PC - Ottawa

Ottawa, Illinois, 61350, United States
Oncology Hematology Associates of Central Illinois, PC - Peoria

Peoria, Illinois, 61615, United States
Perry Memorial Hospital

Princeton, Illinois, 61356, United States
Proctor Hospital

Peoria, Illinois, 61614, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263-0001, United States
SUNY Upstate Medical University Hospital

Syracuse, New York, 13210, United States
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis

St Louis, Missouri, 63110, United States
St. Joseph Medical Center

Bloomington, Illinois, 61701, United States
UCSF Helen Diller Family Comprehensive Cancer Center

San Francisco, California, 94115, United States
University of Chicago Cancer Research Center

Chicago, Illinois, 60637-1470, United States
Wake Forest University Comprehensive Cancer Center

Winston-Salem, North Carolina, 27157-1096, United States