New brain tumor drug combo enters final testing phase
NCT ID NCT07215910
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase III trial is testing whether adding the targeted drug vorasidenib to standard chemotherapy (temozolomide) after radiation helps people with a specific type of brain tumor (IDH-mutated grade 3 astrocytoma). About 408 participants will receive either vorasidenib or a placebo alongside temozolomide. The main goal is to see if the combination delays tumor growth better than standard treatment alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
vorasidenib and temozolomide
What this could lead to
If it works, this could lead to a new standard treatment that delays tumor growth in people with IDH-mutated grade 3 astrocytoma.
What could go wrong
This is an early-stage Phase III trial, so results are not yet known. Adding vorasidenib may cause additional side effects and may not improve outcomes over standard therapy.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Allegheny General Hospital
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
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Broadlawns Medical Center
RECRUITINGDes Moines, Iowa, 50314, United States
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Children's Hospital New Orleans
RECRUITINGNew Orleans, Louisiana, 70118, United States
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Christiana Care Health System-Concord Health Center
RECRUITINGChadds Ford, Pennsylvania, 19317, United States
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City of Hope Comprehensive Cancer Center
RECRUITINGDuarte, California, 91010, United States
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Drexel Town Square Health Center
RECRUITINGOak Creek, Wisconsin, 53154, United States
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East Jefferson General Hospital
RECRUITINGMetairie, Louisiana, 70006, United States
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Forbes Hospital
RECRUITINGMonroeville, Pennsylvania, 15146, United States
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Froedtert Menomonee Falls Hospital
RECRUITINGMenomonee Falls, Wisconsin, 53051, United States
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Froedtert West Bend Hospital/Kraemer Cancer Center
RECRUITINGWest Bend, Wisconsin, 53095, United States
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Froedtert and MCW Moorland Reserve Health Center
RECRUITINGNew Berlin, Wisconsin, 53151, United States
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Helen F Graham Cancer Center
RECRUITINGNewark, Delaware, 19713, United States
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Illinois CancerCare - Washington
RECRUITINGWashington, Illinois, 61571, United States
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Illinois CancerCare-Bloomington
RECRUITINGBloomington, Illinois, 61704, United States
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Illinois CancerCare-Canton
RECRUITINGCanton, Illinois, 61520, United States
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Illinois CancerCare-Carthage
RECRUITINGCarthage, Illinois, 62321, United States
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Illinois CancerCare-Eureka
RECRUITINGEureka, Illinois, 61530, United States
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Illinois CancerCare-Galesburg
RECRUITINGGalesburg, Illinois, 61401, United States
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Illinois CancerCare-Kewanee Clinic
RECRUITINGKewanee, Illinois, 61443, United States
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Illinois CancerCare-Macomb
RECRUITINGMacomb, Illinois, 61455, United States
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Illinois CancerCare-Ottawa Clinic
RECRUITINGOttawa, Illinois, 61350, United States
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Illinois CancerCare-Pekin
RECRUITINGPekin, Illinois, 61554, United States
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Illinois CancerCare-Peoria
RECRUITINGPeoria, Illinois, 61615, United States
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Illinois CancerCare-Peru
RECRUITINGPeru, Illinois, 61354, United States
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Illinois CancerCare-Princeton
RECRUITINGPrinceton, Illinois, 61356, United States
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Iowa Methodist Medical Center
RECRUITINGDes Moines, Iowa, 50309, United States
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MaineHealth Maine Medical Center- Scarborough
RECRUITINGScarborough, Maine, 04074, United States
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Medical Oncology Hematology Consultants PA
RECRUITINGNewark, Delaware, 19713, United States
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Memorial Sloan Kettering Basking Ridge
RECRUITINGBasking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen
RECRUITINGMontvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Memorial Sloan Kettering Commack
RECRUITINGCommack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth
RECRUITINGMiddletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau
RECRUITINGUniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester
RECRUITINGHarrison, New York, 10604, United States
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Mercy Medical Center - Des Moines
RECRUITINGDes Moines, Iowa, 50314, United States
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Midwestern Regional Medical Center
RECRUITINGZion, Illinois, 60099, United States
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NorthShore University HealthSystem-Evanston Hospital
RECRUITINGEvanston, Illinois, 60201, United States
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Northern Westchester Hospital
RECRUITINGMount Kisco, New York, 10549, United States
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Northwell Health Imbert Cancer Center
RECRUITINGBay Shore, New York, 11706, United States
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Northwell Health/Center for Advanced Medicine
RECRUITINGLake Success, New York, 11042, United States
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OSF Saint Francis Medical Center
RECRUITINGPeoria, Illinois, 61637, United States
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OSF Saint Francis Radiation Oncology at Peoria Cancer Center
RECRUITINGPeoria, Illinois, 61615, United States
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OSF Saint Joseph Medical Center
RECRUITINGBloomington, Illinois, 61701, United States
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
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ProHealth D N Greenwald Center
RECRUITINGMukwonago, Wisconsin, 53149, United States
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ProHealth Oconomowoc Memorial Hospital
RECRUITINGOconomowoc, Wisconsin, 53066, United States
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Smilow Cancer Hospital Care Center - Waterford
RECRUITINGWaterford, Connecticut, 06385, United States
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Smilow Cancer Hospital Care Center-Trumbull
RECRUITINGTrumbull, Connecticut, 06611, United States
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Thomas Jefferson University Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
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UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITINGOrange, California, 92868, United States
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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITINGIrvine, California, 92612, United States
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UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITINGAnkeny, Iowa, 50023, United States
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UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITINGDes Moines, Iowa, 50309, United States
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UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITINGDes Moines, Iowa, 50314, United States
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UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITINGWaukee, Iowa, 50263, United States
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UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITINGClive, Iowa, 50325, United States
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UI Healthcare Mission Cancer and Blood - Pella
RECRUITINGPella, Iowa, 50219, United States
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UPMC Hillman Cancer Center Erie
RECRUITINGErie, Pennsylvania, 16505, United States
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UPMC-Shadyside Hospital
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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UW Cancer Center at ProHealth Care
RECRUITINGWaukesha, Wisconsin, 53188, United States
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University Medical Center New Orleans
RECRUITINGNew Orleans, Louisiana, 70112, United States
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University of California Davis Comprehensive Cancer Center
RECRUITINGSacramento, California, 95817, United States
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University of Cincinnati Cancer Center-UC Medical Center
RECRUITINGCincinnati, Ohio, 45219, United States
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University of Cincinnati Cancer Center-West Chester
RECRUITINGWest Chester, Ohio, 45069, United States
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University of Michigan - Brighton Center for Specialty Care
RECRUITINGBrighton, Michigan, 48116, United States
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University of Michigan Rogel Cancer Center
RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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University of Pittsburgh Cancer Institute (UPCI)
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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University of Vermont Medical Center
RECRUITINGBurlington, Vermont, 05401, United States
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University of Vermont and State Agricultural College
RECRUITINGBurlington, Vermont, 05405, United States
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West Jefferson Medical Center
RECRUITINGMarrero, Louisiana, 70072, United States
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Wexford Health and Wellness Pavilion
RECRUITINGWexford, Pennsylvania, 15090, United States
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Yale University
RECRUITINGNew Haven, Connecticut, 06520, United States
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