New brain tumor drug combo enters final testing phase

NCT ID NCT07215910

Recruiting now Disease control Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 3 times

Summary

This Phase III trial is testing whether adding the targeted drug vorasidenib to standard chemotherapy (temozolomide) after radiation helps people with a specific type of brain tumor (IDH-mutated grade 3 astrocytoma). About 408 participants will receive either vorasidenib or a placebo alongside temozolomide. The main goal is to see if the combination delays tumor growth better than standard treatment alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vorasidenib and temozolomide
What this could lead to: If it works, this could lead to a new standard treatment that delays tumor growth in people with IDH-mutated grade 3 astrocytoma.
What could go wrong: This is an early-stage Phase III trial, so results are not yet known. Adding vorasidenib may cause additional side effects and may not improve outcomes over standard therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

astrocytoma (excluding glioblastoma) astrocytoma, IDH-mutant, grade 3 follicular lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTROCYTOMA IDH MUTANT GRADE 3

Contacts and locations

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Locations

Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Broadlawns Medical Center
RECRUITING

Des Moines, Iowa, 50314, United States
Children's Hospital New Orleans
RECRUITING

New Orleans, Louisiana, 70118, United States
Christiana Care Health System-Concord Health Center
RECRUITING

Chadds Ford, Pennsylvania, 19317, United States
City of Hope Comprehensive Cancer Center
RECRUITING

Duarte, California, 91010, United States

Contact Email: •••••@•••••
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Drexel Town Square Health Center
RECRUITING

Oak Creek, Wisconsin, 53154, United States
East Jefferson General Hospital
RECRUITING

Metairie, Louisiana, 70006, United States
Forbes Hospital
RECRUITING

Monroeville, Pennsylvania, 15146, United States
Froedtert Menomonee Falls Hospital
RECRUITING

Menomonee Falls, Wisconsin, 53051, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
RECRUITING

West Bend, Wisconsin, 53095, United States
Froedtert and MCW Moorland Reserve Health Center
RECRUITING

New Berlin, Wisconsin, 53151, United States
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Helen F Graham Cancer Center
RECRUITING

Newark, Delaware, 19713, United States
Illinois CancerCare - Washington
RECRUITING

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington
RECRUITING

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton
RECRUITING

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage
RECRUITING

Carthage, Illinois, 62321, United States
Illinois CancerCare-Eureka
RECRUITING

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg
RECRUITING

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic
RECRUITING

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb
RECRUITING

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic
RECRUITING

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin
RECRUITING

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria
RECRUITING

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru
RECRUITING

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton
RECRUITING

Princeton, Illinois, 61356, United States
Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
RECRUITING

New York, New York, 10016, United States

Contact Email: •••••@•••••
MaineHealth Cancer Care Center of York County
RECRUITING

Sanford, Maine, 04073, United States
MaineHealth Coastal Cancer Treatment Center
RECRUITING

Bath, Maine, 04530, United States
MaineHealth Maine Medical Center - Portland
RECRUITING

Portland, Maine, 04102, United States

Contact Email: •••••@•••••
MaineHealth Maine Medical Center- Scarborough
RECRUITING

Scarborough, Maine, 04074, United States

Contact Email: •••••@•••••
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical Oncology Hematology Consultants PA
RECRUITING

Newark, Delaware, 19713, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States
Mercy Hospital Springfield
RECRUITING

Springfield, Missouri, 65804, United States
Mercy Medical Center - Des Moines
RECRUITING

Des Moines, Iowa, 50314, United States
Midwestern Regional Medical Center
RECRUITING

Zion, Illinois, 60099, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
RECRUITING

New York, New York, 10032, United States

Contact Email: •••••@•••••
NYU Langone Hospital - Brooklyn
RECRUITING

Brooklyn, New York, 11220, United States
NYU Langone Hospital - Long Island
RECRUITING

Mineola, New York, 11501, United States

Contact Email: •••••@•••••
NorthShore University HealthSystem-Evanston Hospital
RECRUITING

Evanston, Illinois, 60201, United States
NorthShore University HealthSystem-Glenbrook Hospital
RECRUITING

Glenview, Illinois, 60026, United States
NorthShore University HealthSystem-Highland Park Hospital
RECRUITING

Highland Park, Illinois, 60035, United States
Northern Westchester Hospital
RECRUITING

Mount Kisco, New York, 10549, United States
Northwell Health Imbert Cancer Center
RECRUITING

Bay Shore, New York, 11706, United States
Northwell Health/Center for Advanced Medicine
RECRUITING

Lake Success, New York, 11042, United States
OSF Saint Francis Medical Center
RECRUITING

Peoria, Illinois, 61637, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
RECRUITING

Peoria, Illinois, 61615, United States
OSF Saint Joseph Medical Center
RECRUITING

Bloomington, Illinois, 61701, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
ProHealth D N Greenwald Center
RECRUITING

Mukwonago, Wisconsin, 53149, United States
ProHealth Oconomowoc Memorial Hospital
RECRUITING

Oconomowoc, Wisconsin, 53066, United States
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

Contact Email: •••••@•••••
Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital Care Center - Waterford
RECRUITING

Waterford, Connecticut, 06385, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital Care Center-Trumbull
RECRUITING

Trumbull, Connecticut, 06611, United States

Contact Email: •••••@•••••
Stony Brook University Medical Center
RECRUITING

Stony Brook, New York, 11794, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Email: •••••@•••••
Trinity Health Grand Rapids Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States

Contact Email: •••••@•••••
UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITING

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITING

Waukee, Iowa, 50263, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITING

Clive, Iowa, 50325, United States
UI Healthcare Mission Cancer and Blood - Pella
RECRUITING

Pella, Iowa, 50219, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UPMC Hillman Cancer Center Erie
RECRUITING

Erie, Pennsylvania, 16505, United States

Contact Email: •••••@•••••
UPMC-Shadyside Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UW Cancer Center at ProHealth Care
RECRUITING

Waukesha, Wisconsin, 53188, United States
United Hospital
RECRUITING

Saint Paul, Minnesota, 55102, United States
University Medical Center New Orleans
RECRUITING

New Orleans, Louisiana, 70112, United States
University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of Cincinnati Cancer Center-UC Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States

Contact Email: •••••@•••••
University of Cincinnati Cancer Center-West Chester
RECRUITING

West Chester, Ohio, 45069, United States

Contact Email: •••••@•••••
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States
University of Michigan - Brighton Center for Specialty Care
RECRUITING

Brighton, Michigan, 48116, United States
University of Michigan Health - West
RECRUITING

Wyoming, Michigan, 49519, United States
University of Michigan Rogel Cancer Center
RECRUITING

Ann Arbor, Michigan, 48109, United States

Contact Email: •••••@•••••
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States
University of Vermont and State Agricultural College
RECRUITING

Burlington, Vermont, 05405, United States
West Jefferson Medical Center
RECRUITING

Marrero, Louisiana, 70072, United States
Wexford Health and Wellness Pavilion
RECRUITING

Wexford, Pennsylvania, 15090, United States
Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

Contact Email: •••••@•••••

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