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New hope for brain cancer patients: experimental combo enters trials

NCT ID NCT05765812

Recruiting now Disease control Sponsor: Debiopharm International SA Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This study tests a new drug (Debio 0123) combined with standard chemotherapy (temozolomide) and sometimes radiation in adults with glioblastoma, an aggressive brain cancer. The goal is to find the safest dose and see if the combination helps people live longer. About 116 participants will take part in two phases: first to check safety, then to compare the new combo against standard care.

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Conditions

The condition(s) this trial relates to.

anaplastic astrocytoma astrocytoma (excluding glioblastoma) astrocytoma, IDH-mutant, grade 3 follicular lymphoma glioblastoma grade III glioma IDH-wildtype glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTROCYTOMA, GRADE III GLIOBLASTOMA IDH (ISOCITRATE DEHYDROGENASE) WILDTYPE

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Baylor Scott & White Research Institute

    RECRUITING

    Dallas, Texas, 75246, United States

  • Clinica Universidad de Navarra (CUN)

    RECRUITING

    Madrid, 28027, Spain

  • Clinica Universidad de Navarra (CUN)

    RECRUITING

    Pamplona, 31008, Spain

  • David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10021, United States

  • Fred Hutchinson Cancer Research Center

    RECRUITING

    Seattle, Washington, 98109, United States

  • Hospital Clinico Universitario de Valencia

    RECRUITING

    Valencia, 46010, Spain

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitario Donostia

    RECRUITING

    Donostia / San Sebastian, 20014, Spain

  • Hospital Universitario Vall d'Hebron

    RECRUITING

    Barcelona, 08035, Spain

  • Huntsman Cancer Institute

    RECRUITING

    Salt Lake City, Utah, 84112, United States

  • New York University Langone Medical Center

    RECRUITING

    New York, New York, 10016, United States

  • Northwestern Memorial Hospital

    RECRUITING

    Chicago, Illinois, 60611, United States

  • South Texas Accelerated Research Therapeutics (START)

    RECRUITING

    San Antonio, Texas, 78229, United States

  • South Texas Accelerated Research Therapeutics (START)

    RECRUITING

    Madrid, 28040, Spain

  • The University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Universitaetsspital Zuerich

    RECRUITING

    Zurich, CH-8091, Switzerland

More trials for these conditions

Other studies related to the condition(s) this trial covers.