New hope for brain cancer patients: experimental combo enters trials
NCT ID NCT05765812
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new drug (Debio 0123) combined with standard chemotherapy (temozolomide) and sometimes radiation in adults with glioblastoma, an aggressive brain cancer. The goal is to find the safest dose and see if the combination helps people live longer. About 116 participants will take part in two phases: first to check safety, then to compare the new combo against standard care.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Baylor Scott & White Research Institute
RECRUITINGDallas, Texas, 75246, United States
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Clinica Universidad de Navarra (CUN)
RECRUITINGMadrid, 28027, Spain
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Clinica Universidad de Navarra (CUN)
RECRUITINGPamplona, 31008, Spain
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David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10021, United States
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Fred Hutchinson Cancer Research Center
RECRUITINGSeattle, Washington, 98109, United States
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Hospital Clinico Universitario de Valencia
RECRUITINGValencia, 46010, Spain
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, 28041, Spain
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Hospital Universitario Donostia
RECRUITINGDonostia / San Sebastian, 20014, Spain
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Hospital Universitario Vall d'Hebron
RECRUITINGBarcelona, 08035, Spain
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Huntsman Cancer Institute
RECRUITINGSalt Lake City, Utah, 84112, United States
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New York University Langone Medical Center
RECRUITINGNew York, New York, 10016, United States
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Northwestern Memorial Hospital
RECRUITINGChicago, Illinois, 60611, United States
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South Texas Accelerated Research Therapeutics (START)
RECRUITINGSan Antonio, Texas, 78229, United States
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South Texas Accelerated Research Therapeutics (START)
RECRUITINGMadrid, 28040, Spain
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The University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Universitaetsspital Zuerich
RECRUITINGZurich, CH-8091, Switzerland