New hope for brain tumor patients: targeted drug shows promise in phase 3 trial
NCT ID NCT05303519
First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times
Summary
This study tests a drug called safusidenib in people with a type of brain tumor (glioma) that has a specific gene mutation (IDH1). The trial has three parts: one for recurrent tumors, one for high-risk tumors after standard treatment, and one for a specific tumor type after surgery alone. The goal is to see if the drug can control the tumor and improve survival.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Beijing Tiantan Hospital, Capital Medical University
RECRUITINGBeijing, Beijing Municipality, 100070, China
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Billings Clinic
RECRUITINGBillings, Montana, 59101, United States
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44106, United States
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Columbia University Medical Center
RECRUITINGNew York, New York, 10032, United States
Contact Email: •••••@•••••
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Duke Cancer Institute
RECRUITINGDurham, North Carolina, 27710, United States
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Fred Hutch Cancer Center
RECRUITINGSeattle, Washington, 98195, United States
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Henry Ford Hospital
RECRUITINGDetroit, Michigan, 48202, United States
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Hoag Memorial Hospital Presbyterian
RECRUITINGNewport Beach, California, 92663, United States
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Huashan Hospital Affiliated to Fudan University
RECRUITINGShanghai, Shanghai Municipality, 200040, China
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Huntsman Cancer Insititute, University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
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Icahn School of Medicine at Mount Sinai
NOT_YET_RECRUITINGNew York, New York, 10029, United States
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Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
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Inova Schar Cancer Institute
NOT_YET_RECRUITINGFairfax, Virginia, 22031, United States
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02214, United States
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Mayo Clinic - Arizona
RECRUITINGPhoenix, Arizona, 85013, United States
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Mayo Clinic - Florida
RECRUITINGJacksonville, Florida, 32224, United States
Contact Email: •••••@•••••
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Mayo Clinic - Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact Email: •••••@•••••
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Mays Cancer Center
NOT_YET_RECRUITINGSan Antonio, Texas, 78229, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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Orlando Health Cancer Institute
RECRUITINGOrlando, Florida, 32806, United States
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Peking Union Medical College Hospital
RECRUITINGBeijing, Beijing Municipality, 100730, China
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Peter MacCallum Cancer Centre
RECRUITINGMelbourne, Victoria, Australia
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Royal Brisbane and Women's Hospital
RECRUITINGHerston, Queensland, Australia
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Royal North Shore Hospital
RECRUITINGSaint Leonards, New South Wales, Australia
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Rutgers Cancer Institute
RECRUITINGNew Brunswick, New Jersey, 08901, United States
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Sanbo Brain Hospital, Capital Medical University
RECRUITINGBeijing, Beijing Municipality, 100093, China
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Sir Charles Gairdner Hospital
NOT_YET_RECRUITINGNedlands, Western Australia, 6009, Australia
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St Vincents Hospital Sydney (Kinghorn)
RECRUITINGDarlinghurst, New South Wales, Australia
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St. Joseph's Hospital and Medical Center
RECRUITINGPhoenix, Arizona, 85013, United States
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Stanford University
RECRUITINGPalo Alto, California, 94304, United States
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Sun Yat-sen University Cancer Center
RECRUITINGGuangzhou, Guangdong, 510060, China
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The Alfred
RECRUITINGMelbourne, Victoria, Australia
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The First Affiliated Hospital of Fujian Medical University
RECRUITINGFuzhou, Fujian, 350005, China
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Thomas Jefferson University Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
Contact Email: •••••@•••••
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UPMC Hillman Cancer Center
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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UVA Health, Emily Couric Clinical Cancer Cente
RECRUITINGCharlottesville, Virginia, 22903, United States
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University of Alabama
RECRUITINGBirmingham, Alabama, 35294, United States
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University of California
RECRUITINGSan Francisco, California, 94143, United States
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University of California San Diego
NOT_YET_RECRUITINGLa Jolla, California, 92093, United States
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University of California, Los Angeles
RECRUITINGLos Angeles, California, 90095, United States
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University of Chicago
NOT_YET_RECRUITINGChicago, Illinois, 60637, United States
Contact Email: •••••@•••••
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University of Colorado Health Cancer Care
RECRUITINGAurora, Colorado, 80045, United States
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University of Florida Health
RECRUITINGGainesville, Florida, 32608, United States
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University of Kansas Medical Center
RECRUITINGKansas City, Kansas, 66160, United States
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University of Miami Health
RECRUITINGMiami, Florida, 33136, United States
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University of Rochester Medical Center
RECRUITINGRochester, New York, 14642, United States
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University of Texas Southwestern Medical Center
RECRUITINGDallas, Texas, 75390, United States
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University of Wisconsin Health
RECRUITINGMadison, Wisconsin, 53792, United States
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Vanderbilt-Ingram Cancer Center
NOT_YET_RECRUITINGNashville, Tennessee, 37203, United States
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Washington University
RECRUITINGSt Louis, Missouri, 63110, United States
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West China Hospital of Sichuan University
RECRUITINGChengdu, Sichuan, 610041, China
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Xiangya Hospital of Central South University
RECRUITINGChangsha, Hunan, 410008, China
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Xuanwu Hospital, Capital Medical University
RECRUITINGBeijing, Beijing Municipality, 10053, China
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Yale University
RECRUITINGNew Haven, Connecticut, 06510, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a virus injected into brain tumors fight recurrence?
- Can a Tumor's genetic blueprint guide better treatment for kids with brain cancer?
- Can adding lenvatinib to standard care outsmart a tough brain cancer?
- Can a sharper beam of radiation shield the mind during brain tumor treatment?
- Can a tiny implant trap brain tumor cells and make radiation work better?
- Can a targeted pill slow brain tumor growth after surgery?