New combo therapy aims to outsmart resistant myeloma
NCT ID NCT06232044
First seen Jun 25, 2026 · Last updated Jul 02, 2026 · Updated 2 times
Summary
This study tests whether adding the drug iberdomide to a standard treatment (belantamab mafodotin plus dexamethasone) is safe and works better for multiple myeloma that has relapsed or become resistant. About 88 participants will receive either the new combo or the standard combo. The goal is to slow or stop cancer growth while managing side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- belantamab mafodotin and iberdomide
- What this could lead to
- If successful, this could offer a new, more effective treatment option for people with multiple myeloma that has returned or stopped responding to other therapies.
- What could go wrong
- This is an early-phase trial with only 88 participants, so results may not apply broadly. The combination may cause significant side effects, and it is not a cure—patients will still need ongoing management.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Coborn Cancer Center at Saint Cloud Hospital
RECRUITINGSaint Cloud, Minnesota, 56303, United States
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Columbus Oncology and Hematology Associates
RECRUITINGDublin, Ohio, 43016, United States
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Columbus Oncology and Hematology Associates Inc
RECRUITINGColumbus, Ohio, 43214, United States
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Delaware Health Center-Grady Cancer Center
RECRUITINGDelaware, Ohio, 43015, United States
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Doctors Hospital
RECRUITINGColumbus, Ohio, 43228, United States
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Dublin Methodist Hospital
RECRUITINGDublin, Ohio, 43016, United States
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Grady Memorial Hospital
RECRUITINGDelaware, Ohio, 43015, United States
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Grant Medical Center
RECRUITINGColumbus, Ohio, 43215, United States
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Huntsman Cancer Institute/University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
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Marshfield Medical Center - Weston
RECRUITINGWeston, Wisconsin, 54476, United States
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Marshfield Medical Center-River Region at Stevens Point
RECRUITINGStevens Point, Wisconsin, 54482, United States
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Mary Greeley Medical Center
RECRUITINGAmes, Iowa, 50010, United States
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McFarland Clinic - Ames
RECRUITINGAmes, Iowa, 50010, United States
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McFarland Clinic - Boone
SUSPENDEDBoone, Iowa, 50036, United States
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McFarland Clinic - Jefferson
SUSPENDEDJefferson, Iowa, 50129, United States
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McFarland Clinic - Marshalltown
RECRUITINGMarshalltown, Iowa, 50158, United States
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McFarland Clinic - Trinity Cancer Center
RECRUITINGFort Dodge, Iowa, 50501, United States
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Memorial Sloan Kettering Bergen
RECRUITINGMontvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Memorial Sloan Kettering Commack
RECRUITINGCommack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth
RECRUITINGMiddletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Westchester
RECRUITINGHarrison, New York, 10604, United States
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OhioHealth Mansfield Hospital
RECRUITINGMansfield, Ohio, 44903, United States
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OhioHealth Marion General Hospital
RECRUITINGMarion, Ohio, 43302, United States
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OhioHealth O'Bleness Hospital
RECRUITINGAthens, Ohio, 45701, United States
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OhioHealth Pickerington Methodist Hospital
RECRUITINGPickerington, Ohio, 43147, United States
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OhioHealth Westerville Medical Campus/Westerville Cancer Center
RECRUITINGWesterville, Ohio, 43082, United States
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ProHealth D N Greenwald Center
RECRUITINGMukwonago, Wisconsin, 53149, United States
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ProHealth Oconomowoc Memorial Hospital
RECRUITINGOconomowoc, Wisconsin, 53066, United States
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ProHealth Waukesha Memorial Hospital
RECRUITINGWaukesha, Wisconsin, 53188, United States
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Riverside Methodist Hospital
RECRUITINGColumbus, Ohio, 43214, United States
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Saint Vincent Hospital Cancer Center Green Bay
RECRUITINGGreen Bay, Wisconsin, 54301, United States
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Saint Vincent Hospital Cancer Center at Saint Mary's
RECRUITINGGreen Bay, Wisconsin, 54303, United States
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Saint Vincent Hospital Cancer Center at Sheboygan
RECRUITINGSheboygan, Wisconsin, 53081, United States
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Saint Vincent Hospital Cancer Center at Sturgeon Bay
RECRUITINGSturgeon Bay, Wisconsin, 54235-1495, United States
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Sheboygan Physicians Group
RECRUITINGSheboygan, Wisconsin, 53081, United States
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Tufts Medical Center
RECRUITINGBoston, Massachusetts, 02111, United States
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UW Cancer Center at ProHealth Care
RECRUITINGWaukesha, Wisconsin, 53188, United States
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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Vanderbilt University/Ingram Cancer Center
RECRUITINGNashville, Tennessee, 37232, United States
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More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a One-Two drug punch beat back Hard-to-Treat myeloma?
- CAR-T breakthroughs come with infection risks – new study aims to decode them
- Double-barreled CAR t therapy takes aim at hard-to-treat myeloma
- Can a drug stop dangerous side effects of new myeloma therapies?
- New hope for myeloma: adaptive trial tests smarter drug combos
- Brain training before CAR-T may protect memory, study hopes