Could a longer break between prostate cancer treatments boost quality of life?

NCT ID NCT07200830

Recruiting now Disease control Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 3 times

Summary

This phase 3 trial for men with advanced, hormone-resistant prostate cancer tests whether giving the drug lutetium-177 PSMA less often (only when the disease shows signs of activity) can improve quality of life without shortening survival. About 1,500 participants will be randomly assigned to either the standard fixed schedule or the adaptive schedule. The goal is to see if a more personalized approach can reduce treatment burden while keeping the cancer under control.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC CASTRATION-RESISTANT PROSTATE CARCINOMA METASTATIC PROSTATE ADENOCARCINOMA STAGE IVB PROSTATE CANCER AJCC V8

Contacts and locations

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Locations

AIS Cancer Center at San Joaquin Community Hospital
RECRUITING

Bakersfield, California, 93301, United States
Abbott-Northwestern Hospital
SUSPENDED

Minneapolis, Minnesota, 55407, United States
Allegiance Health
RECRUITING

Jackson, Michigan, 49201, United States

Contact Email: •••••@•••••
AtlantiCare Health Park-Cape May Court House
RECRUITING

Cape May Court House, New Jersey, 08210, United States
AtlantiCare Surgery Center
RECRUITING

Egg Harbor, New Jersey, 08234, United States
Benefis Helena Specialty Center
SUSPENDED

Helena, Montana, 59601, United States
Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

Contact Email: •••••@•••••
Billings Clinic-Cody
SUSPENDED

Cody, Wyoming, 82414, United States
Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

Contact Email: •••••@•••••
Broadlawns Medical Center
SUSPENDED

Des Moines, Iowa, 50314, United States
CTCA at Southeastern Regional Medical Center
RECRUITING

Newnan, Georgia, 30265, United States
Cambridge Medical Center
SUSPENDED

Cambridge, Minnesota, 55008, United States
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States
Cancer Center of Western Wisconsin
SUSPENDED

New Richmond, Wisconsin, 54017, United States
Capital Health Medical Center-Hopewell
RECRUITING

Pennington, New Jersey, 08534, United States

Contact Email: •••••@•••••
City of Hope at Irvine Lennar
RECRUITING

Irvine, California, 92618, United States
Coborn Cancer Center at Saint Cloud Hospital
RECRUITING

Saint Cloud, Minnesota, 56303, United States

Contact Email: •••••@•••••
Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

Contact Email: •••••@•••••
Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

Contact Email: •••••@•••••
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States
Drexel Town Square Health Center
RECRUITING

Oak Creek, Wisconsin, 53154, United States
Fairview Clinics and Surgery Center Maple Grove
SUSPENDED

Maple Grove, Minnesota, 55369, United States
Fairview Lakes Medical Center
SUSPENDED

Wyoming, Minnesota, 55092, United States
Fairview Northland Medical Center
SUSPENDED

Princeton, Minnesota, 55371, United States
Fairview Southdale Hospital
SUSPENDED

Edina, Minnesota, 55435, United States
Froedtert Menomonee Falls Hospital
RECRUITING

Menomonee Falls, Wisconsin, 53051, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
RECRUITING

West Bend, Wisconsin, 53095, United States
Froedtert and MCW Moorland Reserve Health Center
RECRUITING

New Berlin, Wisconsin, 53151, United States
Great Falls Clinic
SUSPENDED

Great Falls, Montana, 59405, United States
HSHS Saint Elizabeth's Hospital
RECRUITING

O'Fallon, Illinois, 62269, United States
Heartland Regional Medical Center
RECRUITING

Saint Joseph, Missouri, 64506, United States
Helen F Graham Cancer Center
RECRUITING

Newark, Delaware, 19713, United States
Hennepin County Medical Center
SUSPENDED

Minneapolis, Minnesota, 55415, United States
Henry Ford Cancer Institute-Downriver
RECRUITING

Brownstown, Michigan, 48183, United States

Contact Email: •••••@•••••
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States

Contact Email: •••••@•••••
Henry Ford Macomb Hospital-Clinton Township
RECRUITING

Clinton Township, Michigan, 48038, United States

Contact Email: •••••@•••••
Henry Ford Medical Center-Columbus
RECRUITING

Novi, Michigan, 48377, United States

Contact Email: •••••@•••••
Henry Ford Medical Center-Fairlane
RECRUITING

Dearborn, Michigan, 48126, United States

Contact Email: •••••@•••••
Henry Ford West Bloomfield Hospital
RECRUITING

West Bloomfield, Michigan, 48322, United States

Contact Email: •••••@•••••
Henry Ford Wyandotte Hospital
RECRUITING

Wyandotte, Michigan, 48192, United States
Hi-Line Sletten Cancer Center
SUSPENDED

Havre, Montana, 59501, United States
Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States
Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

Contact Email: •••••@•••••
Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

Contact Email: •••••@•••••
Lakeview Hospital
SUSPENDED

Stillwater, Minnesota, 55082, United States
Logan Health Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

Contact Email: •••••@•••••
Mary Greeley Medical Center
RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Ames
RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Boone
SUSPENDED

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson
SUSPENDED

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown
RECRUITING

Marshalltown, Iowa, 50158, United States
McFarland Clinic - Trinity Cancer Center
RECRUITING

Fort Dodge, Iowa, 50501, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical Oncology Hematology Consultants PA
RECRUITING

Newark, Delaware, 19713, United States
Memorial Hospital of Laramie County
SUSPENDED

Cheyenne, Wyoming, 82001, United States
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States
Mercy Hospital
SUSPENDED

Coon Rapids, Minnesota, 55433, United States
MetroHealth Medical Center
RECRUITING

Cleveland, Ohio, 44109, United States
Midwestern Regional Medical Center
RECRUITING

Zion, Illinois, 60099, United States
Minnesota Oncology - Burnsville
SUSPENDED

Burnsville, Minnesota, 55337, United States
Minnesota Oncology Hematology PA-Maplewood
SUSPENDED

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury
SUSPENDED

Woodbury, Minnesota, 55125, United States
Missouri Baptist Medical Center
RECRUITING

St Louis, Missouri, 63131, United States
Montefiore Medical Center - Moses Campus
RECRUITING

The Bronx, New York, 10467, United States
Montefiore Medical Center-Einstein Campus
RECRUITING

The Bronx, New York, 10461, United States
New Ulm Medical Center
SUSPENDED

New Ulm, Minnesota, 56073, United States
North Memorial Medical Health Center
SUSPENDED

Robbinsdale, Minnesota, 55422, United States
Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Park Nicollet Clinic - Saint Louis Park
SUSPENDED

Saint Louis Park, Minnesota, 55416, United States
Providence Alaska Medical Center
RECRUITING

Anchorage, Alaska, 99508, United States
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

Contact Email: •••••@•••••
Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

Contact Email: •••••@•••••
Regions Hospital
SUSPENDED

Saint Paul, Minnesota, 55101, United States
Rice Memorial Hospital
SUSPENDED

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center
SUSPENDED

Waconia, Minnesota, 55387, United States
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
SSM Health Good Samaritan
RECRUITING

Mount Vernon, Illinois, 62864, United States
Saint Anthony Regional Hospital
SUSPENDED

Carroll, Iowa, 51401, United States
Saint Francis Regional Medical Center
SUSPENDED

Shakopee, Minnesota, 55379, United States
Saint John's Hospital - Healtheast
SUSPENDED

Maplewood, Minnesota, 55109, United States
Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

Contact Email: •••••@•••••
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

Contact Email: •••••@•••••
Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

Contact Email: •••••@•••••
Swedish Cancer Institute-Edmonds
RECRUITING

Edmonds, Washington, 98026, United States
Swedish Medical Center-First Hill
RECRUITING

Seattle, Washington, 98122, United States
The Iowa Clinic PC
SUSPENDED

West Des Moines, Iowa, 50266, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
RECRUITING

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States

Contact Email: •••••@•••••
UI Health Care Mission Cancer and Blood - Ankeny Clinic
SUSPENDED

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
SUSPENDED

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
SUSPENDED

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
SUSPENDED

Waukee, Iowa, 50263, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
SUSPENDED

Clive, Iowa, 50325, United States
UI Healthcare Mission Cancer and Blood - Fort Dodge
SUSPENDED

Fort Dodge, Iowa, 50501, United States
UI Healthcare Mission Cancer and Blood - Pella
SUSPENDED

Pella, Iowa, 50219, United States
United Hospital
SUSPENDED

Saint Paul, Minnesota, 55102, United States
University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

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