Could a longer break between prostate cancer treatments boost quality of life?

NCT ID NCT07200830

Recruiting now Disease control Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial for men with advanced, hormone-resistant prostate cancer tests whether giving the drug lutetium-177 PSMA less often (only when the disease shows signs of activity) can improve quality of life without shortening survival. About 1,500 participants will be randomly assigned to either the standard fixed schedule or the adaptive schedule. The goal is to see if a more personalized approach can reduce treatment burden while keeping the cancer under control.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC CASTRATION-RESISTANT PROSTATE CARCINOMA METASTATIC PROSTATE ADENOCARCINOMA STAGE IVB PROSTATE CANCER AJCC V8

Contacts and locations

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Study contacts

Contact

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Locations

AIS Cancer Center at San Joaquin Community Hospital
RECRUITING

Bakersfield, California, 93301, United States

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Abbott-Northwestern Hospital
SUSPENDED

Minneapolis, Minnesota, 55407, United States
AtlantiCare Health Park-Cape May Court House
RECRUITING

Cape May Court House, New Jersey, 08210, United States

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AtlantiCare Surgery Center
RECRUITING

Egg Harbor, New Jersey, 08234, United States

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Benefis Helena Specialty Center
SUSPENDED

Helena, Montana, 59601, United States
Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

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Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

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Billings Clinic-Cody
SUSPENDED

Cody, Wyoming, 82414, United States
Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

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Broadlawns Medical Center
SUSPENDED

Des Moines, Iowa, 50314, United States
CTCA at Southeastern Regional Medical Center
RECRUITING

Newnan, Georgia, 30265, United States

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Cambridge Medical Center
SUSPENDED

Cambridge, Minnesota, 55008, United States
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States

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Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States

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Cancer Center of Western Wisconsin
SUSPENDED

New Richmond, Wisconsin, 54017, United States
City of Hope at Irvine Lennar
RECRUITING

Irvine, California, 92618, United States

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Coborn Cancer Center at Saint Cloud Hospital
RECRUITING

Saint Cloud, Minnesota, 56303, United States

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Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

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Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

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Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States

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Drexel Town Square Health Center
RECRUITING

Oak Creek, Wisconsin, 53154, United States

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Fairview Clinics and Surgery Center Maple Grove
SUSPENDED

Maple Grove, Minnesota, 55369, United States
Fairview Lakes Medical Center
SUSPENDED

Wyoming, Minnesota, 55092, United States
Fairview Northland Medical Center
SUSPENDED

Princeton, Minnesota, 55371, United States
Fairview Southdale Hospital
SUSPENDED

Edina, Minnesota, 55435, United States
Froedtert Menomonee Falls Hospital
RECRUITING

Menomonee Falls, Wisconsin, 53051, United States

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Froedtert West Bend Hospital/Kraemer Cancer Center
RECRUITING

West Bend, Wisconsin, 53095, United States

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Froedtert and MCW Moorland Reserve Health Center
RECRUITING

New Berlin, Wisconsin, 53151, United States

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Great Falls Clinic
SUSPENDED

Great Falls, Montana, 59405, United States
HSHS Saint Elizabeth's Hospital
RECRUITING

O'Fallon, Illinois, 62269, United States

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Heartland Regional Medical Center
RECRUITING

Saint Joseph, Missouri, 64506, United States

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Helen F Graham Cancer Center
RECRUITING

Newark, Delaware, 19713, United States

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Hennepin County Medical Center
SUSPENDED

Minneapolis, Minnesota, 55415, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States

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Hi-Line Sletten Cancer Center
SUSPENDED

Havre, Montana, 59501, United States
Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States

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Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

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Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

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Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

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Lakeview Hospital
SUSPENDED

Stillwater, Minnesota, 55082, United States
Logan Health Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

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Mary Greeley Medical Center
RECRUITING

Ames, Iowa, 50010, United States

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McFarland Clinic - Ames
RECRUITING

Ames, Iowa, 50010, United States

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McFarland Clinic - Boone
SUSPENDED

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson
SUSPENDED

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown
RECRUITING

Marshalltown, Iowa, 50158, United States

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McFarland Clinic - Trinity Cancer Center
RECRUITING

Fort Dodge, Iowa, 50501, United States

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Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States

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Medical Oncology Hematology Consultants PA
RECRUITING

Newark, Delaware, 19713, United States

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Memorial Hospital of Laramie County
SUSPENDED

Cheyenne, Wyoming, 82001, United States
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States

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Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States

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Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

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Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States

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Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States

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Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States

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Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States

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Mercy Hospital
SUSPENDED

Coon Rapids, Minnesota, 55433, United States
Midwestern Regional Medical Center
RECRUITING

Zion, Illinois, 60099, United States

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Contact
Minnesota Oncology - Burnsville
SUSPENDED

Burnsville, Minnesota, 55337, United States
Minnesota Oncology Hematology PA-Maplewood
SUSPENDED

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury
SUSPENDED

Woodbury, Minnesota, 55125, United States
Missouri Baptist Medical Center
RECRUITING

St Louis, Missouri, 63131, United States

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Montefiore Medical Center - Moses Campus
RECRUITING

The Bronx, New York, 10467, United States

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Montefiore Medical Center-Einstein Campus
RECRUITING

The Bronx, New York, 10461, United States

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New Ulm Medical Center
SUSPENDED

New Ulm, Minnesota, 56073, United States
North Memorial Medical Health Center
SUSPENDED

Robbinsdale, Minnesota, 55422, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

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Park Nicollet Clinic - Saint Louis Park
SUSPENDED

Saint Louis Park, Minnesota, 55416, United States
Providence Alaska Medical Center
SUSPENDED

Anchorage, Alaska, 99508, United States
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

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Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

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Regions Hospital
SUSPENDED

Saint Paul, Minnesota, 55101, United States
Rice Memorial Hospital
SUSPENDED

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center
SUSPENDED

Waconia, Minnesota, 55387, United States
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States

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Saint Anthony Regional Hospital
SUSPENDED

Carroll, Iowa, 51401, United States
Saint Francis Regional Medical Center
SUSPENDED

Shakopee, Minnesota, 55379, United States
Saint John's Hospital - Healtheast
SUSPENDED

Maplewood, Minnesota, 55109, United States
Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

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Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

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Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

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Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

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Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

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The Iowa Clinic PC
SUSPENDED

West Des Moines, Iowa, 50266, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
RECRUITING

Ann Arbor, Michigan, 48106, United States

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Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States

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UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States

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UI Health Care Mission Cancer and Blood - Ankeny Clinic
SUSPENDED

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
SUSPENDED

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
SUSPENDED

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
SUSPENDED

Waukee, Iowa, 50263, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
SUSPENDED

Clive, Iowa, 50325, United States
UI Healthcare Mission Cancer and Blood - Fort Dodge
SUSPENDED

Fort Dodge, Iowa, 50501, United States
UI Healthcare Mission Cancer and Blood - Pella
SUSPENDED

Pella, Iowa, 50219, United States
United Hospital
SUSPENDED

Saint Paul, Minnesota, 55102, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

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