New hope for cancer patients: drug may replace opioids for mouth sore pain

NCT ID NCT06992427

Recruiting now Symptom relief Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Jun 10, 2026 · Updated 29 times

Summary

This study tests whether a high dose of gabapentin, a non-opioid pain medicine, can prevent the need for opioid painkillers in people with head and neck cancer who develop painful mouth sores from chemotherapy and radiation. About 228 participants will be randomly assigned to receive either gabapentin or a placebo during their cancer treatment. The goal is to reduce opioid use and its side effects like confusion, constipation, and risk of long-term dependence.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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AIS Cancer Center at San Joaquin Community Hospital
RECRUITING

Bakersfield, California, 93301, United States

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AMG Crystal Lake - Oncology
RECRUITING

Crystal Lake, Illinois, 60014, United States

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AMG Libertyville - Oncology
RECRUITING

Libertyville, Illinois, 60048, United States

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Advocate Christ Medical Center
RECRUITING

Oak Lawn, Illinois, 60453-2699, United States

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Advocate Good Samaritan Hospital
RECRUITING

Downers Grove, Illinois, 60515, United States

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Advocate Good Shepherd Hospital
RECRUITING

Barrington, Illinois, 60010, United States

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Advocate High Tech Medical Park
RECRUITING

Palos Heights, Illinois, 60463, United States

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Advocate Illinois Masonic Medical Center
RECRUITING

Chicago, Illinois, 60657, United States

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Advocate Lutheran General Hospital
RECRUITING

Park Ridge, Illinois, 60068, United States

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Advocate Outpatient Center - Aurora
RECRUITING

Aurora, Illinois, 60506, United States

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Advocate Outpatient Center - Oak Lawn
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Oak Lawn, Illinois, 60453, United States

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Advocate Sherman Hospital
RECRUITING

Elgin, Illinois, 60123, United States

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Advocate South Suburban Hospital
RECRUITING

Hazel Crest, Illinois, 60429, United States

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Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States

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Arizona Center for Cancer Care
RECRUITING

Tempe, Arizona, 85284, United States

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Arizona Center for Cancer Care - Biltmore
RECRUITING

Phoenix, Arizona, 85016, United States

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Arizona Center for Cancer Care - Gilbert
RECRUITING

Gilbert, Arizona, 85297, United States

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Arizona Center for Cancer Care - Osborn
RECRUITING

Scottsdale, Arizona, 85251, United States

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Arizona Center for Cancer Care - Phoenix
RECRUITING

Phoenix, Arizona, 85027, United States

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Arizona Center for Cancer Care - Scottsdale
RECRUITING

Scottsdale, Arizona, 85258, United States

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Arizona Center for Cancer Care-Peoria
RECRUITING

Peoria, Arizona, 85381, United States

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Arizona Center for Cancer Care-Surprise
RECRUITING

Surprise, Arizona, 85374, United States

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Aspirus Cancer Care - James Beck Cancer Center
RECRUITING

Rhinelander, Wisconsin, 54501, United States

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Aspirus Cancer Care - Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54481, United States

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Aspirus Cancer Care - Wisconsin Rapids
RECRUITING

Wisconsin Rapids, Wisconsin, 54494, United States

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Aspirus Medford Hospital
RECRUITING

Medford, Wisconsin, 54451, United States

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Aspirus Regional Cancer Center
RECRUITING

Wausau, Wisconsin, 54401, United States

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Asplundh Cancer Pavilion
RECRUITING

Willow Grove, Pennsylvania, 19090, United States

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Aultman Health Foundation
RECRUITING

Canton, Ohio, 44710, United States

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Aurora Bay Area Medical Group-Marinette
RECRUITING

Marinette, Wisconsin, 54143, United States

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Aurora BayCare Medical Center
RECRUITING

Green Bay, Wisconsin, 54311, United States

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Aurora Cancer Care-Grafton
RECRUITING

Grafton, Wisconsin, 53024, United States

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Aurora Cancer Care-Kenosha South
RECRUITING

Kenosha, Wisconsin, 53142, United States

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Aurora Cancer Care-Milwaukee
RECRUITING

Milwaukee, Wisconsin, 53209, United States

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Aurora Cancer Care-Milwaukee West
RECRUITING

Wauwatosa, Wisconsin, 53226, United States

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Aurora Cancer Care-Racine
RECRUITING

Racine, Wisconsin, 53406, United States

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Aurora Cancer Care-Southern Lakes VLCC
RECRUITING

Burlington, Wisconsin, 53105, United States

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Aurora Health Care Germantown Health Center
RECRUITING

Germantown, Wisconsin, 53022, United States

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Aurora Medical Center in Summit
RECRUITING

Summit, Wisconsin, 53066, United States

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Aurora Saint Luke's Medical Center
RECRUITING

Milwaukee, Wisconsin, 53215, United States

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Aurora Saint Luke's South Shore
RECRUITING

Cudahy, Wisconsin, 53110, United States

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Aurora Sinai Medical Center
RECRUITING

Milwaukee, Wisconsin, 53233, United States

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Aurora West Allis Medical Center
RECRUITING

West Allis, Wisconsin, 53227, United States

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Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

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Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

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Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

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CHI Health Good Samaritan
SUSPENDED

Kearney, Nebraska, 68847, United States
Camden Clark Medical Center
RECRUITING

Parkersburg, West Virginia, 26101, United States

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Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States

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Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States

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Carle BroMenn Medical Center
SUSPENDED

Normal, Illinois, 61761, United States
Carle Cancer Center
SUSPENDED

Urbana, Illinois, 61801, United States
Carle Cancer Institute Normal
SUSPENDED

Normal, Illinois, 61761, United States
Carle Physician Group-Effingham
SUSPENDED

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston
SUSPENDED

Mattoon, Illinois, 61938, United States
Carle at The Riverfront
SUSPENDED

Danville, Illinois, 61832, United States
Coborn Cancer Center at Saint Cloud Hospital
RECRUITING

Saint Cloud, Minnesota, 56303, United States

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Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

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Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

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Condell Memorial Hospital
RECRUITING

Libertyville, Illinois, 60048, United States

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Crossroads Cancer Center
RECRUITING

Effingham, Illinois, 62401, United States

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Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States

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Drexel Town Square Health Center
RECRUITING

Oak Creek, Wisconsin, 53154, United States

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Farmington Health Center
RECRUITING

Farmington, Utah, 84025, United States

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Forbes Hospital
RECRUITING

Monroeville, Pennsylvania, 15146, United States

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Freeman Health System
RECRUITING

Joplin, Missouri, 64804, United States

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Froedtert Menomonee Falls Hospital
RECRUITING

Menomonee Falls, Wisconsin, 53051, United States

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Froedtert West Bend Hospital/Kraemer Cancer Center
RECRUITING

West Bend, Wisconsin, 53095, United States

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Geisinger Cancer Center Dickson City
RECRUITING

Dickson City, Pennsylvania, 18519, United States

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Geisinger Cancer Services-Pottsville
RECRUITING

Pottsville, Pennsylvania, 17901, United States

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Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17822, United States

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Geisinger Medical Oncology-Lewisburg
RECRUITING

Lewisburg, Pennsylvania, 17837, United States

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Geisinger Wyoming Valley/Henry Cancer Center
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States

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Gibbs Cancer Center-Pelham
RECRUITING

Greer, South Carolina, 29651, United States

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Gundersen Lutheran Medical Center
RECRUITING

La Crosse, Wisconsin, 54601, United States

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HSHS Saint Elizabeth's Hospital
RECRUITING

O'Fallon, Illinois, 62269, United States

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Harold Alfond Center for Cancer Care
RECRUITING

Augusta, Maine, 04330, United States

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Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

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Illinois CancerCare - Washington
RECRUITING

Washington, Illinois, 61571, United States

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Illinois CancerCare-Bloomington
RECRUITING

Bloomington, Illinois, 61704, United States

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Illinois CancerCare-Canton
RECRUITING

Canton, Illinois, 61520, United States

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Illinois CancerCare-Carthage
RECRUITING

Carthage, Illinois, 62321, United States

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Illinois CancerCare-Dixon
RECRUITING

Dixon, Illinois, 61021, United States

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Illinois CancerCare-Eureka
RECRUITING

Eureka, Illinois, 61530, United States

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Illinois CancerCare-Galesburg
RECRUITING

Galesburg, Illinois, 61401, United States

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Illinois CancerCare-Kewanee Clinic
RECRUITING

Kewanee, Illinois, 61443, United States

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Illinois CancerCare-Macomb
RECRUITING

Macomb, Illinois, 61455, United States

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Illinois CancerCare-Ottawa Clinic
RECRUITING

Ottawa, Illinois, 61350, United States

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Illinois CancerCare-Pekin
RECRUITING

Pekin, Illinois, 61554, United States

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Illinois CancerCare-Peoria
RECRUITING

Peoria, Illinois, 61615, United States

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Illinois CancerCare-Peru
RECRUITING

Peru, Illinois, 61354, United States

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Illinois CancerCare-Princeton
RECRUITING

Princeton, Illinois, 61356, United States

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Jefferson Cherry Hill Hospital
RECRUITING

Cherry Hill, New Jersey, 08002, United States

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Jefferson Hospital
RECRUITING

Jefferson Hills, Pennsylvania, 15025, United States

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Jefferson Torresdale Hospital
RECRUITING

Philadelphia, Pennsylvania, 19114, United States

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Kaiser Permanente Downtown Commons
ACTIVE_NOT_RECRUITING

Sacramento, California, 95814, United States
Kaiser Permanente Dublin
ACTIVE_NOT_RECRUITING

Dublin, California, 94568, United States
Kaiser Permanente Fresno Orchard Plaza
ACTIVE_NOT_RECRUITING

Fresno, California, 93720, United States
Kaiser Permanente Medical Center - Santa Clara
ACTIVE_NOT_RECRUITING

Santa Clara, California, 95051, United States
Kaiser Permanente Moanalua Medical Center
ACTIVE_NOT_RECRUITING

Honolulu, Hawaii, 96819, United States
Kaiser Permanente San Leandro
ACTIVE_NOT_RECRUITING

San Leandro, California, 94577, United States
Kaiser Permanente- Modesto MOB II
ACTIVE_NOT_RECRUITING

Modesto, California, 95356, United States
Kaiser Permanente-Franklin
RECRUITING

Denver, Colorado, 80205, United States

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Kaiser Permanente-Fremont
ACTIVE_NOT_RECRUITING

Fremont, California, 94538, United States
Kaiser Permanente-Modesto
ACTIVE_NOT_RECRUITING

Modesto, California, 95356, United States
Kaiser Permanente-Oakland
ACTIVE_NOT_RECRUITING

Oakland, California, 94611, United States
Kaiser Permanente-Rock Creek
RECRUITING

Lafayette, Colorado, 80026, United States

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Kaiser Permanente-Roseville
ACTIVE_NOT_RECRUITING

Roseville, California, 95661, United States
Kaiser Permanente-San Francisco
ACTIVE_NOT_RECRUITING

San Francisco, California, 94115, United States
Kaiser Permanente-Santa Rosa
ACTIVE_NOT_RECRUITING

Santa Rosa, California, 95403, United States
Kaiser Permanente-Santa Teresa-San Jose
ACTIVE_NOT_RECRUITING

San Jose, California, 95119, United States
Kaiser Permanente-South Sacramento
ACTIVE_NOT_RECRUITING

Sacramento, California, 95823, United States
Kaiser Permanente-South San Francisco
ACTIVE_NOT_RECRUITING

South San Francisco, California, 94080, United States
Kaiser Permanente-Vallejo
ACTIVE_NOT_RECRUITING

Vallejo, California, 94589, United States
Kaiser Permanente-Walnut Creek
ACTIVE_NOT_RECRUITING

Walnut Creek, California, 94596, United States
Kaiser San Rafael-Gallinas
ACTIVE_NOT_RECRUITING

San Rafael, California, 94903, United States
Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

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Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

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Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

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Langlade Hospital and Cancer Center
RECRUITING

Antigo, Wisconsin, 54409, United States

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Lenox Hill Hospital
RECRUITING

New York, New York, 10075, United States

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Logan Health Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

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Los Angeles General Medical Center
RECRUITING

Los Angeles, California, 90033, United States

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MaineHealth Cancer Care Center of York County
RECRUITING

Sanford, Maine, 04073, United States

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MaineHealth Cancer Care and IV Therapy - Brunswick
RECRUITING

Brunswick, Maine, 04011, United States

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MaineHealth Cancer Care and IV Therapy - South Portland
RECRUITING

South Portland, Maine, 04106, United States

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MaineHealth Coastal Cancer Treatment Center
RECRUITING

Bath, Maine, 04530, United States

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MaineHealth LincolnHealth Hospital
RECRUITING

Damariscotta, Maine, 04543, United States

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MaineHealth Maine Medical Center - Portland
RECRUITING

Portland, Maine, 04102, United States

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MaineHealth Maine Medical Center- Scarborough
RECRUITING

Scarborough, Maine, 04074, United States

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Manhattan Eye Ear and Throat Hospital
RECRUITING

New York, New York, 10065, United States

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Mary Greeley Medical Center
RECRUITING

Ames, Iowa, 50010, United States

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McFarland Clinic - Ames
RECRUITING

Ames, Iowa, 50010, United States

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McFarland Clinic - Boone
SUSPENDED

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson
SUSPENDED

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown
RECRUITING

Marshalltown, Iowa, 50158, United States

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McFarland Clinic - Trinity Cancer Center
RECRUITING

Fort Dodge, Iowa, 50501, United States

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Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States

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Mercy Hospital
RECRUITING

Cedar Rapids, Iowa, 52403, United States

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Mercy Hospital Saint Louis
RECRUITING

St Louis, Missouri, 63141, United States

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Mercy Hospital South
RECRUITING

St Louis, Missouri, 63128, United States

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Methodist Jennie Edmundson Hospital
SUSPENDED

Council Bluffs, Iowa, 51503, United States
Montefiore Medical Center - Moses Campus
RECRUITING

The Bronx, New York, 10467, United States

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Montefiore Medical Center-Einstein Campus
RECRUITING

The Bronx, New York, 10461, United States

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Nebraska Medicine-Bellevue
RECRUITING

Bellevue, Nebraska, 68123, United States

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Nebraska Medicine-Village Pointe
RECRUITING

Omaha, Nebraska, 68118, United States

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Nebraska Methodist Hospital
RECRUITING

Omaha, Nebraska, 68114, United States

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Northwell Health Physicians Partners Radiation Medicine at Queens
RECRUITING

Forest Hills, New York, 11375, United States

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Northwell Health/Center for Advanced Medicine
RECRUITING

Lake Success, New York, 11042, United States

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Contact Phone: •••-•••-••••
Oncology Associates at Mercy Medical Center
RECRUITING

Cedar Rapids, Iowa, 52403, United States

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Contact Phone: •••-•••-••••
Princeton Community Hospital
RECRUITING

Princeton, West Virginia, 24740, United States

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Contact Phone: •••-•••-••••
Queens Cancer Center
RECRUITING

Rego Park, New York, 11374, United States

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Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Rush-Copley Medical Center
SUSPENDED

Aurora, Illinois, 60504, United States
Saint Anthony Hospital
RECRUITING

Lakewood, Colorado, 80228, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Saint Luke's Cancer Institute - Fruitland
RECRUITING

Fruitland, Idaho, 83619, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Saint Luke's Cancer Institute - Meridian
RECRUITING

Meridian, Idaho, 83642, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Saint Luke's Cancer Institute - Nampa
RECRUITING

Nampa, Idaho, 83687, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Saint Luke's Hospital
RECRUITING

Cedar Rapids, Iowa, 52402, United States

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Saint Vincent Hospital
RECRUITING

Erie, Pennsylvania, 16544, United States

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Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

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Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

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Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Sanford Joe Lueken Cancer Center
RECRUITING

Bemidji, Minnesota, 56601, United States

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Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

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Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Sidney Kimmel Cancer Center Washington Township
RECRUITING

Sewell, New Jersey, 08080, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
South Jordan Health Center
RECRUITING

South Jordan, Utah, 84009, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States

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Contact Phone: •••-•••-••••
Spartanburg Medical Center
RECRUITING

Spartanburg, South Carolina, 29303, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States

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Contact Phone: •••-•••-••••
Springfield Memorial Hospital
RECRUITING

Springfield, Illinois, 62781, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
Stony Brook University Medical Center
RECRUITING

Stony Brook, New York, 11794, United States

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Contact Phone: •••-•••-••••
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Trinity Medical Center
SUSPENDED

Moline, Illinois, 61265, United States
UPMC Cancer Center - Monroeville
RECRUITING

Monroeville, Pennsylvania, 15146, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
UPMC Cancer Center at UPMC Horizon
RECRUITING

Farrell, Pennsylvania, 16121, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
UPMC Cancer Center at UPMC Northwest
RECRUITING

Seneca, Pennsylvania, 16346, United States

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Contact Phone: •••-•••-••••
UPMC Cancer Centers - Arnold Palmer Pavilion
RECRUITING

Greensburg, Pennsylvania, 15601, United States

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Contact Phone: •••-•••-••••
UPMC Hillman Cancer Center - Monroeville
RECRUITING

Monroeville, Pennsylvania, 15146, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
UPMC Hillman Cancer Center Erie
RECRUITING

Erie, Pennsylvania, 16505, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
RECRUITING

Mechanicsburg, Pennsylvania, 17050, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
RECRUITING

Harrisburg, Pennsylvania, 17109, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
UPMC-Saint Clair Hospital Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15243, United States

Contact

Contact Phone: •••-•••-••••
UPMC-Shadyside Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States

Contact

Contact Phone: •••-•••-••••
USC / Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States

Contact

Contact Phone: •••-•••-••••
United Hospital Center
RECRUITING

Bridgeport, West Virginia, 26330, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Pittsburgh Cancer Institute (UPCI)
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States

Contact

Contact Phone: •••-•••-••••
University of Utah Sugarhouse Health Center
RECRUITING

Salt Lake City, Utah, 84106, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Vince Lombardi Cancer Clinic - Oshkosh
RECRUITING

Oshkosh, Wisconsin, 54904, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Vince Lombardi Cancer Clinic-Sheboygan
RECRUITING

Sheboygan, Wisconsin, 53081, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Vince Lombardi Cancer Clinic-Two Rivers
RECRUITING

Two Rivers, Wisconsin, 54241, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
WVUH-Berkely Medical Center
RECRUITING

Martinsburg, West Virginia, 25401, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
West Virginia University Healthcare
RECRUITING

Morgantown, West Virginia, 26506, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Wexford Health and Wellness Pavilion
RECRUITING

Wexford, Pennsylvania, 15090, United States

Contact

Contact Email: •••••@•••••
Wheeling Hospital/Schiffler Cancer Center
RECRUITING

Wheeling, West Virginia, 26003, United States

Contact

Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.