New hope for cancer patients: drug may replace opioids for mouth sore pain

NCT ID NCT06992427

Recruiting now Symptom relief Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a high dose of gabapentin, a non-opioid pain medicine, can prevent the need for opioid painkillers in people with head and neck cancer who develop painful mouth sores from chemotherapy and radiation. About 228 participants will be randomly assigned to receive either gabapentin or a placebo during their cancer treatment. The goal is to reduce opioid use and its side effects like confusion, constipation, and risk of long-term dependence.

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Conditions

The condition(s) this trial relates to.

head and neck squamous cell carcinoma skin squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK SQUAMOUS CELL CARCINOMA STAGE I HEAD AND NECK CUTANEOUS SQUAMOUS CELL CARCINOMA AJCC V8 STAGE II HEAD AND NECK CUTANEOUS SQUAMOUS CELL CARCINOMA AJCC V8 STAGE III HEAD AND NECK CUTANEOUS SQUAMOUS CELL CARCINOMA AJCC V8 STAGE IV HEAD AND NECK CUTANEOUS SQUAMOUS CELL CARCINOMA AJCC V8

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

AIS Cancer Center at San Joaquin Community Hospital
RECRUITING

Bakersfield, California, 93301, United States
AMG Crystal Lake - Oncology
RECRUITING

Crystal Lake, Illinois, 60014, United States

Contact Email: •••••@•••••
AMG Libertyville - Oncology
RECRUITING

Libertyville, Illinois, 60048, United States

Contact Email: •••••@•••••
Advocate Christ Medical Center
RECRUITING

Oak Lawn, Illinois, 60453-2699, United States
Advocate Good Samaritan Hospital
RECRUITING

Downers Grove, Illinois, 60515, United States
Advocate Good Shepherd Hospital
RECRUITING

Barrington, Illinois, 60010, United States
Advocate High Tech Medical Park
RECRUITING

Palos Heights, Illinois, 60463, United States
Advocate Illinois Masonic Medical Center
RECRUITING

Chicago, Illinois, 60657, United States
Advocate Lutheran General Hospital
RECRUITING

Park Ridge, Illinois, 60068, United States
Advocate Outpatient Center - Aurora
RECRUITING

Aurora, Illinois, 60506, United States
Advocate Outpatient Center - Oak Lawn
RECRUITING

Oak Lawn, Illinois, 60453, United States
Advocate Sherman Hospital
RECRUITING

Elgin, Illinois, 60123, United States
Advocate South Suburban Hospital
RECRUITING

Hazel Crest, Illinois, 60429, United States
Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Arizona Center for Cancer Care
RECRUITING

Tempe, Arizona, 85284, United States
Arizona Center for Cancer Care - Biltmore
RECRUITING

Phoenix, Arizona, 85016, United States
Arizona Center for Cancer Care - Gilbert
RECRUITING

Gilbert, Arizona, 85297, United States
Arizona Center for Cancer Care - Osborn
RECRUITING

Scottsdale, Arizona, 85251, United States
Arizona Center for Cancer Care - Phoenix
RECRUITING

Phoenix, Arizona, 85027, United States
Arizona Center for Cancer Care - Scottsdale
RECRUITING

Scottsdale, Arizona, 85258, United States
Arizona Center for Cancer Care-Peoria
RECRUITING

Peoria, Arizona, 85381, United States
Arizona Center for Cancer Care-Surprise
RECRUITING

Surprise, Arizona, 85374, United States
Aspirus Cancer Care - James Beck Cancer Center
RECRUITING

Rhinelander, Wisconsin, 54501, United States
Aspirus Cancer Care - Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54481, United States
Aspirus Cancer Care - Wisconsin Rapids
RECRUITING

Wisconsin Rapids, Wisconsin, 54494, United States
Aspirus Medford Hospital
RECRUITING

Medford, Wisconsin, 54451, United States
Aspirus Regional Cancer Center
RECRUITING

Wausau, Wisconsin, 54401, United States
Asplundh Cancer Pavilion
RECRUITING

Willow Grove, Pennsylvania, 19090, United States

Contact Email: •••••@•••••
Aultman Health Foundation
RECRUITING

Canton, Ohio, 44710, United States

Contact Email: •••••@•••••
Aurora Bay Area Medical Group-Marinette
RECRUITING

Marinette, Wisconsin, 54143, United States
Aurora BayCare Medical Center
RECRUITING

Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Grafton
RECRUITING

Grafton, Wisconsin, 53024, United States
Aurora Cancer Care-Kenosha South
RECRUITING

Kenosha, Wisconsin, 53142, United States
Aurora Cancer Care-Milwaukee
RECRUITING

Milwaukee, Wisconsin, 53209, United States
Aurora Cancer Care-Milwaukee West
RECRUITING

Wauwatosa, Wisconsin, 53226, United States
Aurora Cancer Care-Racine
RECRUITING

Racine, Wisconsin, 53406, United States
Aurora Cancer Care-Southern Lakes VLCC
RECRUITING

Burlington, Wisconsin, 53105, United States
Aurora Health Care Germantown Health Center
RECRUITING

Germantown, Wisconsin, 53022, United States
Aurora Medical Center in Summit
RECRUITING

Summit, Wisconsin, 53066, United States
Aurora Saint Luke's Medical Center
RECRUITING

Milwaukee, Wisconsin, 53215, United States
Aurora Saint Luke's South Shore
RECRUITING

Cudahy, Wisconsin, 53110, United States
Aurora Sinai Medical Center
RECRUITING

Milwaukee, Wisconsin, 53233, United States
Aurora West Allis Medical Center
RECRUITING

West Allis, Wisconsin, 53227, United States
Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

Contact Email: •••••@•••••
Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

Contact Email: •••••@•••••
CHI Health Good Samaritan
SUSPENDED

Kearney, Nebraska, 68847, United States
Camden Clark Medical Center
RECRUITING

Parkersburg, West Virginia, 26101, United States

Contact Email: •••••@•••••
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States
Carle BroMenn Medical Center
SUSPENDED

Normal, Illinois, 61761, United States
Carle Cancer Center
SUSPENDED

Urbana, Illinois, 61801, United States
Carle Cancer Institute Normal
SUSPENDED

Normal, Illinois, 61761, United States
Carle Physician Group-Effingham
SUSPENDED

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston
SUSPENDED

Mattoon, Illinois, 61938, United States
Carle at The Riverfront
SUSPENDED

Danville, Illinois, 61832, United States
Coborn Cancer Center at Saint Cloud Hospital
RECRUITING

Saint Cloud, Minnesota, 56303, United States

Contact Email: •••••@•••••
Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

Contact Email: •••••@•••••
Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

Contact Email: •••••@•••••
Condell Memorial Hospital
RECRUITING

Libertyville, Illinois, 60048, United States

Contact Email: •••••@•••••
Crossroads Cancer Center
RECRUITING

Effingham, Illinois, 62401, United States
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States
Drexel Town Square Health Center
RECRUITING

Oak Creek, Wisconsin, 53154, United States
Farmington Health Center
RECRUITING

Farmington, Utah, 84025, United States

Contact Email: •••••@•••••
Forbes Hospital
RECRUITING

Monroeville, Pennsylvania, 15146, United States
Freeman Health System
RECRUITING

Joplin, Missouri, 64804, United States
Froedtert Menomonee Falls Hospital
RECRUITING

Menomonee Falls, Wisconsin, 53051, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
RECRUITING

West Bend, Wisconsin, 53095, United States
Geisinger Cancer Center Dickson City
RECRUITING

Dickson City, Pennsylvania, 18519, United States

Contact Email: •••••@•••••
Geisinger Cancer Services-Pottsville
RECRUITING

Pottsville, Pennsylvania, 17901, United States

Contact Email: •••••@•••••
Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17822, United States

Contact Email: •••••@•••••
Geisinger Medical Oncology-Lewisburg
RECRUITING

Lewisburg, Pennsylvania, 17837, United States

Contact Email: •••••@•••••
Geisinger Wyoming Valley/Henry Cancer Center
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States

Contact Email: •••••@•••••
Gibbs Cancer Center-Pelham
RECRUITING

Greer, South Carolina, 29651, United States
Gundersen Lutheran Medical Center
RECRUITING

La Crosse, Wisconsin, 54601, United States

Contact Email: •••••@•••••
HSHS Saint Elizabeth's Hospital
RECRUITING

O'Fallon, Illinois, 62269, United States
Harold Alfond Center for Cancer Care
RECRUITING

Augusta, Maine, 04330, United States
Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

Contact Email: •••••@•••••
Illinois CancerCare - Washington
RECRUITING

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington
RECRUITING

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton
RECRUITING

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage
RECRUITING

Carthage, Illinois, 62321, United States
Illinois CancerCare-Dixon
RECRUITING

Dixon, Illinois, 61021, United States
Illinois CancerCare-Eureka
RECRUITING

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg
RECRUITING

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic
RECRUITING

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb
RECRUITING

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic
RECRUITING

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin
RECRUITING

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria
RECRUITING

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru
RECRUITING

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton
RECRUITING

Princeton, Illinois, 61356, United States
Jefferson Cherry Hill Hospital
RECRUITING

Cherry Hill, New Jersey, 08002, United States

Contact Email: •••••@•••••
Jefferson Hospital
RECRUITING

Jefferson Hills, Pennsylvania, 15025, United States
Jefferson Torresdale Hospital
RECRUITING

Philadelphia, Pennsylvania, 19114, United States

Contact Email: •••••@•••••
Kaiser Permanente Downtown Commons
ACTIVE_NOT_RECRUITING

Sacramento, California, 95814, United States
Kaiser Permanente Dublin
ACTIVE_NOT_RECRUITING

Dublin, California, 94568, United States
Kaiser Permanente Fresno Orchard Plaza
ACTIVE_NOT_RECRUITING

Fresno, California, 93720, United States
Kaiser Permanente Medical Center - Santa Clara
ACTIVE_NOT_RECRUITING

Santa Clara, California, 95051, United States
Kaiser Permanente Moanalua Medical Center
ACTIVE_NOT_RECRUITING

Honolulu, Hawaii, 96819, United States
Kaiser Permanente San Leandro
ACTIVE_NOT_RECRUITING

San Leandro, California, 94577, United States
Kaiser Permanente- Modesto MOB II
ACTIVE_NOT_RECRUITING

Modesto, California, 95356, United States
Kaiser Permanente-Franklin
RECRUITING

Denver, Colorado, 80205, United States

Contact Email: •••••@•••••
Kaiser Permanente-Fremont
ACTIVE_NOT_RECRUITING

Fremont, California, 94538, United States
Kaiser Permanente-Modesto
ACTIVE_NOT_RECRUITING

Modesto, California, 95356, United States
Kaiser Permanente-Oakland
ACTIVE_NOT_RECRUITING

Oakland, California, 94611, United States
Kaiser Permanente-Rock Creek
RECRUITING

Lafayette, Colorado, 80026, United States

Contact Email: •••••@•••••
Kaiser Permanente-Roseville
ACTIVE_NOT_RECRUITING

Roseville, California, 95661, United States
Kaiser Permanente-San Francisco
ACTIVE_NOT_RECRUITING

San Francisco, California, 94115, United States
Kaiser Permanente-Santa Rosa
ACTIVE_NOT_RECRUITING

Santa Rosa, California, 95403, United States
Kaiser Permanente-Santa Teresa-San Jose
ACTIVE_NOT_RECRUITING

San Jose, California, 95119, United States
Kaiser Permanente-South Sacramento
ACTIVE_NOT_RECRUITING

Sacramento, California, 95823, United States
Kaiser Permanente-South San Francisco
ACTIVE_NOT_RECRUITING

South San Francisco, California, 94080, United States
Kaiser Permanente-Vallejo
ACTIVE_NOT_RECRUITING

Vallejo, California, 94589, United States
Kaiser Permanente-Walnut Creek
ACTIVE_NOT_RECRUITING

Walnut Creek, California, 94596, United States
Kaiser San Rafael-Gallinas
ACTIVE_NOT_RECRUITING

San Rafael, California, 94903, United States
Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

Contact Email: •••••@•••••
Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

Contact Email: •••••@•••••
Langlade Hospital and Cancer Center
RECRUITING

Antigo, Wisconsin, 54409, United States
Lenox Hill Hospital
RECRUITING

New York, New York, 10075, United States
Logan Health Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

Contact Email: •••••@•••••
Los Angeles General Medical Center
RECRUITING

Los Angeles, California, 90033, United States

Contact Email: •••••@•••••
MaineHealth Cancer Care Center of York County
RECRUITING

Sanford, Maine, 04073, United States
MaineHealth Cancer Care and IV Therapy - Brunswick
RECRUITING

Brunswick, Maine, 04011, United States

Contact Email: •••••@•••••
MaineHealth Cancer Care and IV Therapy - South Portland
RECRUITING

South Portland, Maine, 04106, United States

Contact Email: •••••@•••••
MaineHealth Coastal Cancer Treatment Center
RECRUITING

Bath, Maine, 04530, United States
MaineHealth LincolnHealth Hospital
RECRUITING

Damariscotta, Maine, 04543, United States

Contact Email: •••••@•••••
MaineHealth Maine Medical Center - Portland
RECRUITING

Portland, Maine, 04102, United States

Contact Email: •••••@•••••
MaineHealth Maine Medical Center- Scarborough
RECRUITING

Scarborough, Maine, 04074, United States

Contact Email: •••••@•••••
Manhattan Eye Ear and Throat Hospital
RECRUITING

New York, New York, 10065, United States
Mary Greeley Medical Center
RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Ames
RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Boone
SUSPENDED

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson
SUSPENDED

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown
RECRUITING

Marshalltown, Iowa, 50158, United States
McFarland Clinic - Trinity Cancer Center
RECRUITING

Fort Dodge, Iowa, 50501, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Mercy Hospital
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Mercy Hospital Saint Louis
RECRUITING

St Louis, Missouri, 63141, United States
Mercy Hospital South
RECRUITING

St Louis, Missouri, 63128, United States
Methodist Jennie Edmundson Hospital
SUSPENDED

Council Bluffs, Iowa, 51503, United States
Montefiore Medical Center - Moses Campus
RECRUITING

The Bronx, New York, 10467, United States
Montefiore Medical Center-Einstein Campus
RECRUITING

The Bronx, New York, 10461, United States
Nebraska Medicine-Bellevue
RECRUITING

Bellevue, Nebraska, 68123, United States
Nebraska Medicine-Village Pointe
RECRUITING

Omaha, Nebraska, 68118, United States
Nebraska Methodist Hospital
RECRUITING

Omaha, Nebraska, 68114, United States
Northwell Health Physicians Partners Radiation Medicine at Queens
RECRUITING

Forest Hills, New York, 11375, United States
Northwell Health/Center for Advanced Medicine
RECRUITING

Lake Success, New York, 11042, United States
Oncology Associates at Mercy Medical Center
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Princeton Community Hospital
RECRUITING

Princeton, West Virginia, 24740, United States
Queens Cancer Center
RECRUITING

Rego Park, New York, 11374, United States
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Rush-Copley Medical Center
SUSPENDED

Aurora, Illinois, 60504, United States
Saint Anthony Hospital
RECRUITING

Lakewood, Colorado, 80228, United States

Contact Email: •••••@•••••
Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States
Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland
RECRUITING

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian
RECRUITING

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa
RECRUITING

Nampa, Idaho, 83687, United States
Saint Luke's Hospital
RECRUITING

Cedar Rapids, Iowa, 52402, United States
Saint Vincent Hospital
RECRUITING

Erie, Pennsylvania, 16544, United States
Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

Contact Email: •••••@•••••
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

Contact Email: •••••@•••••
Sanford Joe Lueken Cancer Center
RECRUITING

Bemidji, Minnesota, 56601, United States

Contact Email: •••••@•••••
Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

Contact Email: •••••@•••••
Sidney Kimmel Cancer Center Washington Township
RECRUITING

Sewell, New Jersey, 08080, United States

Contact Email: •••••@•••••
South Jordan Health Center
RECRUITING

South Jordan, Utah, 84009, United States

Contact Email: •••••@•••••
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States
Spartanburg Medical Center
RECRUITING

Spartanburg, South Carolina, 29303, United States
Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital
RECRUITING

Springfield, Illinois, 62781, United States
Stony Brook University Medical Center
RECRUITING

Stony Brook, New York, 11794, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Email: •••••@•••••
Trinity Medical Center
SUSPENDED

Moline, Illinois, 61265, United States
UPMC Cancer Center - Monroeville
RECRUITING

Monroeville, Pennsylvania, 15146, United States
UPMC Cancer Center at UPMC Horizon
RECRUITING

Farrell, Pennsylvania, 16121, United States
UPMC Cancer Center at UPMC Northwest
RECRUITING

Seneca, Pennsylvania, 16346, United States
UPMC Cancer Centers - Arnold Palmer Pavilion
RECRUITING

Greensburg, Pennsylvania, 15601, United States
UPMC Hillman Cancer Center - Monroeville
RECRUITING

Monroeville, Pennsylvania, 15146, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center Erie
RECRUITING

Erie, Pennsylvania, 16505, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
RECRUITING

Mechanicsburg, Pennsylvania, 17050, United States
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
RECRUITING

Harrisburg, Pennsylvania, 17109, United States
UPMC-Saint Clair Hospital Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15243, United States
UPMC-Shadyside Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
USC / Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
United Hospital Center
RECRUITING

Bridgeport, West Virginia, 26330, United States

Contact Email: •••••@•••••
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Pittsburgh Cancer Institute (UPCI)
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Utah Sugarhouse Health Center
RECRUITING

Salt Lake City, Utah, 84106, United States

Contact Email: •••••@•••••
Vince Lombardi Cancer Clinic - Oshkosh
RECRUITING

Oshkosh, Wisconsin, 54904, United States
Vince Lombardi Cancer Clinic-Sheboygan
RECRUITING

Sheboygan, Wisconsin, 53081, United States
Vince Lombardi Cancer Clinic-Two Rivers
RECRUITING

Two Rivers, Wisconsin, 54241, United States
WVUH-Berkely Medical Center
RECRUITING

Martinsburg, West Virginia, 25401, United States

Contact Email: •••••@•••••
West Virginia University Healthcare
RECRUITING

Morgantown, West Virginia, 26506, United States

Contact Email: •••••@•••••
Wexford Health and Wellness Pavilion
RECRUITING

Wexford, Pennsylvania, 15090, United States
Wheeling Hospital/Schiffler Cancer Center
RECRUITING

Wheeling, West Virginia, 26003, United States

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