New trial zaps spreading colon cancer with precision: could it be a Game-Changer?

NCT ID NCT05673148

Recruiting now Disease control Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 06, 2026 · Updated 4 times

Summary

This phase III trial is testing whether adding focused treatments—like high-dose radiation, surgery, or heat ablation—to standard chemotherapy can help people with colorectal cancer that has spread to up to four sites. The goal is to see if destroying those metastatic tumors improves overall survival compared to chemo alone. About 364 participants will be randomly assigned to receive either standard chemo or chemo plus these targeted procedures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Stereotactic ablative radiotherapy, surgical resection, and microwave ablation
What this could lead to: If successful, this approach could extend survival for people with colorectal cancer that has spread to a few spots, by destroying those tumors directly.
What could go wrong: This is an early-stage phase III trial, so results are not yet proven. The added procedures carry risks like infection, bleeding, or damage to nearby organs, and may not improve outcomes over standard chemo alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC COLORECTAL ADENOCARCINOMA STAGE IV COLORECTAL CANCER AJCC V8

Contacts and locations

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Locations

Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Allegiance Health
ACTIVE_NOT_RECRUITING

Jackson, Michigan, 49201, United States
Arthur J E Child Comprehensive Cancer Centre
SUSPENDED

Calgary, Alberta, T2N 5G2, Canada
Ascension All Saints Hospital-Spring Street-Racine
RECRUITING

Racine, Wisconsin, 53405, United States
Ascension Calumet Hospital-Chilton
RECRUITING

Chilton, Wisconsin, 53014, United States
Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
RECRUITING

Milwaukee, Wisconsin, 53211, United States
Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
RECRUITING

Mequon, Wisconsin, 53097, United States
Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh
RECRUITING

Oshkosh, Wisconsin, 54904, United States
Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton
RECRUITING

Appleton, Wisconsin, 54915, United States
Ascension Southeast Wisconsin Hospital - Franklin
RECRUITING

Franklin, Wisconsin, 53132, United States
Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
RECRUITING

Brookfield, Wisconsin, 53045, United States
Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
RECRUITING

Wauwatosa, Wisconsin, 53226, United States
Ascension Southeast Wisconsin Hospital-Saint Joseph-Milwaukee
RECRUITING

Milwaukee, Wisconsin, 53210, United States
Aspirus Cancer Care - Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54481, United States
Aspirus Cancer Care - Wisconsin Rapids
RECRUITING

Wisconsin Rapids, Wisconsin, 54494, United States
Aspirus Cancer Care-Antigo-Volm Cancer Center
RECRUITING

Antigo, Wisconsin, 54409, United States
Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
RECRUITING

Rhinelander, Wisconsin, 54501, United States
Aspirus Cancer Care-Wausau
RECRUITING

Wausau, Wisconsin, 54401, United States
Atrium Health Cabarrus/LCI-Concord
RECRUITING

Concord, North Carolina, 28025, United States
Atrium Medical Center-Middletown Regional Hospital
RECRUITING

Franklin, Ohio, 45005-1066, United States

Contact Email: •••••@•••••
Baptist Cancer Center-Grenada
RECRUITING

Grenada, Mississippi, 38901, United States

Contact Email: •••••@•••••
Baptist Health Floyd
RECRUITING

New Albany, Indiana, 47150, United States
Baptist Health Louisville
RECRUITING

Louisville, Kentucky, 40207, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Desoto
RECRUITING

Southhaven, Mississippi, 38671, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Golden Triangle
RECRUITING

Columbus, Mississippi, 39705, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Memphis
RECRUITING

Memphis, Tennessee, 38120, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Oxford
RECRUITING

Oxford, Mississippi, 38655, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Union County
RECRUITING

New Albany, Mississippi, 38652, United States

Contact Email: •••••@•••••
Beebe Health Campus
RECRUITING

Rehoboth Beach, Delaware, 19971, United States

Contact Email: •••••@•••••
Beebe Medical Center
RECRUITING

Lewes, Delaware, 19958, United States

Contact Email: •••••@•••••
Beebe South Coastal Health Campus
RECRUITING

Millville, Delaware, 19967, United States

Contact Email: •••••@•••••
Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

Contact Email: •••••@•••••
Bon Secours Cancer Institute at Reynolds Crossing
RECRUITING

Richmond, Virginia, 23230, United States
Bon Secours Memorial Regional Medical Center
RECRUITING

Mechanicsville, Virginia, 23116, United States
Bon Secours Saint Francis Medical Center
RECRUITING

Midlothian, Virginia, 23114, United States
Bon Secours Saint Mary's Hospital
RECRUITING

Richmond, Virginia, 23226, United States
Boston Medical Center
RECRUITING

Boston, Massachusetts, 02118, United States
Carolinas Medical Center/Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28203, United States
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States

Contact Email: •••••@•••••
Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Christiana Care Health System-Christiana Hospital
RECRUITING

Newark, Delaware, 19718, United States
Christiana Care Health System-Concord Health Center
RECRUITING

Chadds Ford, Pennsylvania, 19317, United States
Christiana Care Health System-Wilmington Hospital
RECRUITING

Wilmington, Delaware, 19801, United States
Corewell Health Beaumont Troy Hospital
RECRUITING

Troy, Michigan, 48085, United States
Corewell Health Dearborn Hospital
RECRUITING

Dearborn, Michigan, 48124, United States
Corewell Health Farmington Hills Hospital
RECRUITING

Farmington Hills, Michigan, 48336, United States
Corewell Health William Beaumont University Hospital
RECRUITING

Royal Oak, Michigan, 48073, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Dayton Physician LLC - Englewood
ACTIVE_NOT_RECRUITING

Dayton, Ohio, 45415, United States
Dayton Physicians LLC-Atrium
ACTIVE_NOT_RECRUITING

Franklin, Ohio, 45005, United States
Dayton Physicians LLC-Miami Valley South
ACTIVE_NOT_RECRUITING

Centerville, Ohio, 45459, United States
East Carolina University
RECRUITING

Greenville, North Carolina, 27834, United States
Edwards Comprehensive Cancer Center
RECRUITING

Huntington, West Virginia, 25701, United States
Emory Proton Therapy Center
RECRUITING

Atlanta, Georgia, 30308, United States
Emory Saint Joseph's Hospital
RECRUITING

Atlanta, Georgia, 30342, United States
Emory University Hospital Midtown
RECRUITING

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Englewood Hospital and Medical Center
RECRUITING

Englewood, New Jersey, 07631, United States
Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17822, United States

Contact Email: •••••@•••••
Geisinger Medical Oncology-Lewisburg
RECRUITING

Lewisburg, Pennsylvania, 17837, United States

Contact Email: •••••@•••••
Geisinger Wyoming Valley/Henry Cancer Center
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States

Contact Email: •••••@•••••
Genesys Hurley Cancer Institute
RECRUITING

Flint, Michigan, 48503, United States
George Washington University Medical Center
RECRUITING

Washington D.C., District of Columbia, 20037, United States
Grady Health System
RECRUITING

Atlanta, Georgia, 30303, United States
Greater Regional Medical Center
RECRUITING

Creston, Iowa, 50801, United States
Heartland Regional Medical Center
RECRUITING

Saint Joseph, Missouri, 64506, United States
Helen F Graham Cancer Center
RECRUITING

Newark, Delaware, 19713, United States
Henry Ford Health Providence Novi Hospital
ACTIVE_NOT_RECRUITING

Novi, Michigan, 48374, United States
Henry Ford Health Providence Southfield Hospital
ACTIVE_NOT_RECRUITING

Southfield, Michigan, 48075, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States

Contact Email: •••••@•••••
Henry Ford Macomb Hospital-Clinton Township
ACTIVE_NOT_RECRUITING

Clinton Township, Michigan, 48038, United States
Henry Ford West Bloomfield Hospital
ACTIVE_NOT_RECRUITING

West Bloomfield, Michigan, 48322, United States
Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

Contact Email: •••••@•••••
Hurley Medical Center
RECRUITING

Flint, Michigan, 48503, United States
Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States
Jersey Shore Medical Center
RECRUITING

Neptune City, New Jersey, 07753, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
ACTIVE_NOT_RECRUITING

Baltimore, Maryland, 21287, United States
Jupiter Medical Center
ACTIVE_NOT_RECRUITING

Jupiter, Florida, 33458, United States
Kingman Regional Medical Center
RECRUITING

Kingman, Arizona, 86401, United States

Contact Email: •••••@•••••
Lancaster General Ann B Barshinger Cancer Institute
ACTIVE_NOT_RECRUITING

Lancaster, Pennsylvania, 17601, United States
Lenox Hill Hospital
SUSPENDED

New York, New York, 10075, United States
MU Health - University Hospital/Ellis Fischel Cancer Center
RECRUITING

Columbia, Missouri, 65212, United States
Manhattan Eye Ear and Throat Hospital
SUSPENDED

New York, New York, 10065, United States
Mayo Clinic Hospital in Arizona
RECRUITING

Phoenix, Arizona, 85054, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical Oncology Hematology Consultants PA
RECRUITING

Newark, Delaware, 19713, United States
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States
Mercy Cancer Center-West Lakes
RECRUITING

Clive, Iowa, 50325, United States
Mercy Hospital Saint Louis
RECRUITING

St Louis, Missouri, 63141, United States
Mercy Hospital South
RECRUITING

St Louis, Missouri, 63128, United States
Mercy Hospital Springfield
RECRUITING

Springfield, Missouri, 65804, United States
Mercy Medical Center - Des Moines
RECRUITING

Des Moines, Iowa, 50314, United States
Mercy Medical Center-West Lakes
RECRUITING

West Des Moines, Iowa, 50266, United States
MetroHealth Medical Center
ACTIVE_NOT_RECRUITING

Cleveland, Ohio, 44109, United States
Miami Cancer Institute
ACTIVE_NOT_RECRUITING

Miami, Florida, 33176, United States
Miami Valley Cancer Care and Infusion
RECRUITING

Greenville, Ohio, 45331, United States
Miami Valley Hospital
RECRUITING

Dayton, Ohio, 45409, United States

Contact Email: •••••@•••••
Miami Valley Hospital North
RECRUITING

Dayton, Ohio, 45415, United States

Contact Email: •••••@•••••
Miami Valley Hospital South
RECRUITING

Centerville, Ohio, 45459, United States

Contact Email: •••••@•••••
Missouri Baptist Medical Center
RECRUITING

St Louis, Missouri, 63131, United States
Missouri Baptist Sullivan Hospital
RECRUITING

Sullivan, Missouri, 63080, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
Mount Sinai West
RECRUITING

New York, New York, 10019, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

New York, New York, 10032, United States
NYP/Weill Cornell Medical Center
RECRUITING

New York, New York, 10065, United States
Nebraska Medicine-Bellevue
RECRUITING

Bellevue, Nebraska, 68123, United States
Nebraska Medicine-Village Pointe
RECRUITING

Omaha, Nebraska, 68118, United States
New York-Presbyterian/Brooklyn Methodist Hospital
RECRUITING

Brooklyn, New York, 11215, United States
Northern Westchester Hospital
SUSPENDED

Mount Kisco, New York, 10549, United States
Northwell Health Cancer Institute at Huntington
SUSPENDED

Greenlawn, New York, 11740, United States
Northwell Health Physicians Partners Radiation Medicine at Queens
SUSPENDED

Forest Hills, New York, 11375, United States
Northwell Health/Center for Advanced Medicine
SUSPENDED

Lake Success, New York, 11042, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States

Contact Email: •••••@•••••
Parkland Health Center - Farmington
RECRUITING

Farmington, Missouri, 63640, United States
Penn State Milton S Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033-0850, United States
Phelps Memorial Hospital Center
SUSPENDED

Sleepy Hollow, New York, 10591, United States
Premier Blood and Cancer Center
RECRUITING

Dayton, Ohio, 45409, United States
Queens Cancer Center
SUSPENDED

Rego Park, New York, 11374, United States
Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Renown Regional Medical Center
RECRUITING

Reno, Nevada, 89502, United States
Saint Charles Health System
RECRUITING

Bend, Oregon, 97701, United States
Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland
RECRUITING

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian
RECRUITING

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa
RECRUITING

Nampa, Idaho, 83687, United States
Saint Luke's Cancer Institute - Twin Falls
RECRUITING

Twin Falls, Idaho, 83301, United States
Sainte Genevieve County Memorial Hospital
RECRUITING

Sainte Genevieve, Missouri, 63670, United States
Sanford Bismarck Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

Contact Email: •••••@•••••
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford Cancer Center Oncology Clinic
RECRUITING

Sioux Falls, South Dakota, 57104, United States

Contact Email: •••••@•••••
Sanford Joe Lueken Cancer Center
RECRUITING

Bemidji, Minnesota, 56601, United States

Contact Email: •••••@•••••
Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

Contact Email: •••••@•••••
Sibley Memorial Hospital
ACTIVE_NOT_RECRUITING

Washington D.C., District of Columbia, 20016, United States
The New York Hospital Medical Center of Queens
RECRUITING

Flushing, New York, 11355, United States
Tower Cancer Research Foundation
RECRUITING

Beverly Hills, California, 90211, United States

Contact Email: •••••@•••••
Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States
Trinity Health Medical Center - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health Medical Center - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
RECRUITING

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States

Contact Email: •••••@•••••
UF Health Cancer Institute - Gainesville
RECRUITING

Gainesville, Florida, 32610, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITING

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITING

Waukee, Iowa, 50263, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITING

Clive, Iowa, 50325, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
RECRUITING

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Coral Springs
RECRUITING

Coral Springs, Florida, 33065, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Doral
RECRUITING

Doral, Florida, 33166, United States
UM Sylvester Comprehensive Cancer Center at Hollywood
RECRUITING

Hollywood, Florida, 33021, United States
UM Sylvester Comprehensive Cancer Center at Kendall
RECRUITING

Miami, Florida, 33176, United States
UM Sylvester Comprehensive Cancer Center at Plantation
RECRUITING

Plantation, Florida, 33324, United States
University Medical Center New Orleans
RECRUITING

New Orleans, Louisiana, 70112, United States
University of California Davis Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

Sacramento, California, 95817, United States
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States
University of Iowa Healthcare Cancer Services Quad Cities
RECRUITING

Bettendorf, Iowa, 52722, United States
University of Iowa/Holden Comprehensive Cancer Center
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kentucky/Markey Cancer Center
ACTIVE_NOT_RECRUITING

Lexington, Kentucky, 40536, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Michigan Health - Sparrow Lansing
RECRUITING

Lansing, Michigan, 48912, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of New Mexico Cancer Center
RECRUITING

Albuquerque, New Mexico, 87106, United States
University of Oklahoma Health Sciences Center
ACTIVE_NOT_RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Rochester
ACTIVE_NOT_RECRUITING

Rochester, New York, 14642, United States
University of Texas Health Science Center at San Antonio
WITHDRAWN

San Antonio, Texas, 78229, United States
Upper Valley Medical Center
RECRUITING

Troy, Ohio, 45373, United States

Contact Email: •••••@•••••
Valley Medical Center
RECRUITING

Renton, Washington, 98055, United States

Contact Email: •••••@•••••
Vanderbilt University/Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States
Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States
West Penn Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Westchester Medical Center
RECRUITING

Valhalla, New York, 10595, United States
Wilmot Cancer Institute at Webster
ACTIVE_NOT_RECRUITING

Webster, New York, 14580, United States

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