Double chemo attack may stall tough prostate cancer

NCT ID NCT06470243

Recruiting now Disease control Sponsor: SWOG Cancer Research Network Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase III trial tests whether adding carboplatin to the standard chemo drug cabazitaxel helps men with metastatic castrate-resistant prostate cancer live longer without their cancer worsening. About 528 men will be randomly assigned to get cabazitaxel alone or cabazitaxel plus carboplatin. The study focuses on men whose tumors have a specific aggressive genetic signature.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cabazitaxel and carboplatin (chemotherapy drugs)
What this could lead to: If it works, this combination could slow cancer growth better than standard treatment alone for men with aggressive prostate cancer.
What could go wrong: This is a large phase III trial, but adding carboplatin may increase side effects without improving outcomes. Results are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CASTRATION-RESISTANT PROSTATE CARCINOMA STAGE IVB PROSTATE CANCER AJCC V8

Contacts and locations

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Locations

Abbott-Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States
Armes Family Cancer Center
RECRUITING

Findlay, Ohio, 45840, United States

Contact Email: •••••@•••••
BJC Outpatient Center at Sunset Hills
RECRUITING

Sunset Hills, Missouri, 63127, United States
Beebe Health Campus
RECRUITING

Rehoboth Beach, Delaware, 19971, United States

Contact Email: •••••@•••••
Beebe Medical Center
RECRUITING

Lewes, Delaware, 19958, United States

Contact Email: •••••@•••••
Beebe South Coastal Health Campus
RECRUITING

Millville, Delaware, 19967, United States

Contact Email: •••••@•••••
Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

Contact Email: •••••@•••••
Billings Clinic-Cody
RECRUITING

Cody, Wyoming, 82414, United States

Contact Email: •••••@•••••
Blanchard Valley Hospital
RECRUITING

Findlay, Ohio, 45840, United States

Contact Email: •••••@•••••
Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

Contact Email: •••••@•••••
Cambridge Medical Center
RECRUITING

Cambridge, Minnesota, 55008, United States
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States
Cancer Center of Western Wisconsin
RECRUITING

New Richmond, Wisconsin, 54017, United States
Caro Cancer Center
RECRUITING

Caro, Michigan, 48723, United States
Centralia Oncology Clinic
RECRUITING

Centralia, Illinois, 62801, United States
Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Christiana Care - Union Hospital
RECRUITING

Elkton, Maryland, 21921, United States
Christiana Care Health System-Christiana Hospital
RECRUITING

Newark, Delaware, 19718, United States
Christiana Care Health System-Concord Health Center
RECRUITING

Chadds Ford, Pennsylvania, 19317, United States
Christiana Care Health System-Wilmington Hospital
RECRUITING

Wilmington, Delaware, 19801, United States
Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

Contact Email: •••••@•••••
Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

Contact Email: •••••@•••••
Crossroads Cancer Center
RECRUITING

Effingham, Illinois, 62401, United States
Dayton Physician LLC - Englewood
RECRUITING

Dayton, Ohio, 45415, United States

Contact Email: •••••@•••••
Dayton Physicians LLC - Troy
RECRUITING

Troy, Ohio, 45373, United States

Contact Email: •••••@•••••
Dayton Physicians LLC-Atrium
RECRUITING

Franklin, Ohio, 45005, United States

Contact Email: •••••@•••••
Dayton Physicians LLC-Miami Valley South
RECRUITING

Centerville, Ohio, 45459, United States

Contact Email: •••••@•••••
Dayton Physicians LLC-Wayne
RECRUITING

Greenville, Ohio, 45331, United States

Contact Email: •••••@•••••
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States
Fairview Clinics and Surgery Center Maple Grove
RECRUITING

Maple Grove, Minnesota, 55369, United States
Fairview Lakes Medical Center
RECRUITING

Wyoming, Minnesota, 55092, United States
Fairview Northland Medical Center
RECRUITING

Princeton, Minnesota, 55371, United States
Fairview Southdale Hospital
RECRUITING

Edina, Minnesota, 55435, United States
Genesee Cancer and Blood Disease Treatment Center
RECRUITING

Flint, Michigan, 48503, United States
Genesee Hematology Oncology PC
RECRUITING

Flint, Michigan, 48503, United States
Genesys Hurley Cancer Institute
RECRUITING

Flint, Michigan, 48503, United States
Great Falls Clinic
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Great Lakes Cancer Management Specialists-Doctors Park
RECRUITING

East China Township, Michigan, 48054, United States
Great Lakes Cancer Management Specialists-Macomb Medical Campus
RECRUITING

Macomb, Michigan, 48044, United States
Great Lakes Cancer Management Specialists-Macomb Professional Building
RECRUITING

Warren, Michigan, 48093, United States
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
RECRUITING

Grosse Pointe Woods, Michigan, 48236, United States
Greater Dayton Cancer Center
RECRUITING

Kettering, Ohio, 45409, United States

Contact Email: •••••@•••••
HSHS Saint Elizabeth's Hospital
RECRUITING

O'Fallon, Illinois, 62269, United States
Health Partners Inc
RECRUITING

Minneapolis, Minnesota, 55454, United States
Helen F Graham Cancer Center
RECRUITING

Newark, Delaware, 19713, United States
Hematology Oncology Consultants-Clarkston
RECRUITING

Clarkston, Michigan, 48346, United States
Hennepin County Medical Center
RECRUITING

Minneapolis, Minnesota, 55415, United States
Henry Ford Health Saint John Hospital
RECRUITING

Detroit, Michigan, 48236, United States
Henry Ford Madison Heights Hospital - Breast
RECRUITING

Warren, Michigan, 48093, United States
Henry Ford Saint John Hospital - Academic
RECRUITING

Grosse Pointe Woods, Michigan, 48236, United States
Henry Ford Saint John Hospital - Breast
RECRUITING

Grosse Pointe Woods, Michigan, 48236, United States
Henry Ford Warren Hospital - Breast Macomb
RECRUITING

Macomb, Michigan, 48044, United States
Highlands Oncology Group
RECRUITING

Springdale, Arkansas, 72762, United States

Contact Email: •••••@•••••
Highlands Oncology Group - Fayetteville
RECRUITING

Fayetteville, Arkansas, 72703, United States

Contact Email: •••••@•••••
Highlands Oncology Group - Rogers
RECRUITING

Rogers, Arkansas, 72758, United States

Contact Email: •••••@•••••
Holy Cross Hospital
RECRUITING

Fort Lauderdale, Florida, 33308, United States
Hope Cancer Center
RECRUITING

Pontiac, Michigan, 48341, United States
Hurley Medical Center
RECRUITING

Flint, Michigan, 48503, United States
Huron Gastroenterology PC
RECRUITING

Ypsilanti, Michigan, 48106, United States
Idaho Urologic Institute-Meridian
RECRUITING

Meridian, Idaho, 83642, United States
Illinois CancerCare - Washington
RECRUITING

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington
RECRUITING

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton
RECRUITING

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage
RECRUITING

Carthage, Illinois, 62321, United States
Illinois CancerCare-Dixon
RECRUITING

Dixon, Illinois, 61021, United States
Illinois CancerCare-Eureka
RECRUITING

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg
RECRUITING

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic
RECRUITING

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb
RECRUITING

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic
RECRUITING

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin
RECRUITING

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria
RECRUITING

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru
RECRUITING

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton
RECRUITING

Princeton, Illinois, 61356, United States
Indu and Raj Soin Medical Center
RECRUITING

Beavercreek, Ohio, 45431, United States

Contact Email: •••••@•••••
Kalispell Regional Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

Contact Email: •••••@•••••
Kettering Medical Center
RECRUITING

Kettering, Ohio, 45429, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

Contact Email: •••••@•••••
Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

Contact Email: •••••@•••••
Lakeview Hospital
RECRUITING

Stillwater, Minnesota, 55082, United States
Lehigh Valley Hospital - Muhlenberg
RECRUITING

Bethlehem, Pennsylvania, 18017, United States
Lehigh Valley Hospital-Cedar Crest
RECRUITING

Allentown, Pennsylvania, 18103, United States
Lehigh Valley Hospital-Hazleton
RECRUITING

Hazleton, Pennsylvania, 18201, United States
Lyndon Baines Johnson General Hospital
RECRUITING

Houston, Texas, 77026-1967, United States
M D Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
MD Anderson League City
RECRUITING

League City, Texas, 77573, United States
MD Anderson West Houston
RECRUITING

Houston, Texas, 77079, United States
MD Anderson in Sugar Land
RECRUITING

Sugar Land, Texas, 77478, United States
MD Anderson in The Woodlands
RECRUITING

Conroe, Texas, 77384, United States
Medical Oncology Hematology Consultants PA
RECRUITING

Newark, Delaware, 19713, United States
Memorial Hospital of Carbondale
RECRUITING

Carbondale, Illinois, 62902, United States

Contact Email: •••••@•••••
Memorial Medical Center
RECRUITING

Springfield, Illinois, 62781, United States
Mercy Hospital
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States
Methodist Medical Center of Illinois
RECRUITING

Peoria, Illinois, 61636, United States
Michigan Healthcare Professionals Pontiac
RECRUITING

Pontiac, Michigan, 48341, United States
Minnesota Oncology - Burnsville
RECRUITING

Burnsville, Minnesota, 55337, United States
Minnesota Oncology Hematology PA-Maplewood
RECRUITING

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury
RECRUITING

Woodbury, Minnesota, 55125, United States
Missouri Baptist Medical Center
RECRUITING

St Louis, Missouri, 63131, United States
Missouri Baptist Sullivan Hospital
RECRUITING

Sullivan, Missouri, 63080, United States
Monticello Cancer Center
RECRUITING

Monticello, Minnesota, 55362, United States
MyMichigan Medical Center Saginaw
RECRUITING

Saginaw, Michigan, 48601, United States
MyMichigan Medical Center Tawas
RECRUITING

Tawas City, Michigan, 48764, United States
Nebraska Medicine-Bellevue
RECRUITING

Bellevue, Nebraska, 68123, United States
Nebraska Medicine-Village Pointe
RECRUITING

Omaha, Nebraska, 68118, United States
New Ulm Medical Center
RECRUITING

New Ulm, Minnesota, 56073, United States
Newland Medical Associates-Clarkston
RECRUITING

Clarkston, Michigan, 48346, United States
Newland Medical Associates-Pontiac
RECRUITING

Pontiac, Michigan, 48341, United States
North Memorial Medical Health Center
RECRUITING

Robbinsdale, Minnesota, 55422, United States
Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States
Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States
Northwestern Medicine Glenview Outpatient Center
RECRUITING

Glenview, Illinois, 60026, United States
Northwestern Medicine Grayslake Outpatient Center
RECRUITING

Grayslake, Illinois, 60030, United States
Northwestern Medicine Lake Forest Hospital
RECRUITING

Lake Forest, Illinois, 60045, United States

Contact Email: •••••@•••••
Northwestern Medicine Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Oncology Associates at Mercy Medical Center
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Oncology Hematology Associates of Saginaw Valley PC
RECRUITING

Saginaw, Michigan, 48604, United States
Oncology Hematology Care Inc-Kenwood
RECRUITING

Cincinnati, Ohio, 45236, United States

Contact Email: •••••@•••••
Orion Cancer Care
RECRUITING

Findlay, Ohio, 45840, United States

Contact Email: •••••@•••••
Park Nicollet Clinic - Saint Louis Park
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
Parkland Health Center - Farmington
RECRUITING

Farmington, Missouri, 63640, United States
Pocono Medical Center
RECRUITING

East Stroudsburg, Pennsylvania, 18301, United States
Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Reid Health
RECRUITING

Richmond, Indiana, 47374, United States

Contact Email: •••••@•••••
Rice Memorial Hospital
RECRUITING

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center
RECRUITING

Waconia, Minnesota, 55387, United States
SIH Cancer Institute
RECRUITING

Carterville, Illinois, 62918, United States

Contact Email: •••••@•••••
Saint Alphonsus Cancer Care Center-Baker City
RECRUITING

Baker City, Oregon, 97814, United States

Contact Email: •••••@•••••
Saint Alphonsus Cancer Care Center-Boise
RECRUITING

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell
RECRUITING

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa
RECRUITING

Nampa, Idaho, 83687, United States

Contact Email: •••••@•••••
Saint Alphonsus Cancer Care Center-Ontario
RECRUITING

Ontario, Oregon, 97914, United States

Contact Email: •••••@•••••
Saint Elizabeth Boardman Hospital
RECRUITING

Boardman, Ohio, 44512, United States

Contact Email: •••••@•••••
Saint Elizabeth Youngstown Hospital
RECRUITING

Youngstown, Ohio, 44501, United States

Contact Email: •••••@•••••
Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States
Saint Francis Regional Medical Center
RECRUITING

Shakopee, Minnesota, 55379, United States
Saint John Macomb-Oakland Hospital
RECRUITING

Warren, Michigan, 48093, United States
Saint John's Hospital - Healtheast
RECRUITING

Maplewood, Minnesota, 55109, United States
Saint Joseph Warren Hospital
RECRUITING

Warren, Ohio, 44484, United States

Contact Email: •••••@•••••
Saint Mary's Oncology/Hematology Associates of Marlette
RECRUITING

Marlette, Michigan, 48453, United States
Saint Mary's Oncology/Hematology Associates of West Branch
RECRUITING

West Branch, Michigan, 48661, United States
Sainte Genevieve County Memorial Hospital
RECRUITING

Sainte Genevieve, Missouri, 63670, United States
Southeast Cancer Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States
The West Clinic - Wolf River
RECRUITING

Germantown, Tennessee, 38138, United States
Tibor Rubin VA Medical Center
RECRUITING

Long Beach, California, 90822, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States
Trinity Health Medical Center - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health Medical Center - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
RECRUITING

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States
United Hospital
RECRUITING

Saint Paul, Minnesota, 55102, United States
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States
University of Michigan Health - Sparrow Lansing
RECRUITING

Lansing, Michigan, 48912, United States
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39216, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
VCU Massey Cancer Center at Stony Point
RECRUITING

Richmond, Virginia, 23235, United States
Valley Radiation Oncology
RECRUITING

Peru, Illinois, 61354, United States
Virginia Commonwealth University/Massey Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Wayne Hospital
RECRUITING

Greenville, Ohio, 45331, United States

Contact Email: •••••@•••••
Welch Cancer Center
RECRUITING

Sheridan, Wyoming, 82801, United States

Contact Email: •••••@•••••
Western Illinois Cancer Treatment Center
RECRUITING

Galesburg, Illinois, 61401, United States

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