STAGE IVA PROSTATE CANCER AJCC V8

This study tests whether high-dose vitamin D can prevent bone loss caused by hormone therapy (ADT) in older men with prostate cancer. About 240 men aged 50+ who are starting or recently started ADT will take either high-dose vitamin D or a placebo for a year. Researchers will mea…

This study compares a new, shorter radiation treatment (5 sessions over 2 weeks) to the standard longer treatment (20-45 sessions over 4-9 weeks) for men with high-risk prostate cancer. The goal is to see if the shorter approach is just as effective at preventing the cancer from …

This study compares two hormone therapy combinations (leuprolide or relugolix plus abiraterone acetate) in men with advanced prostate cancer who are also getting radiation. The goal is to see which combination causes less harm to the heart, since these treatments can raise blood …

This study tests whether giving a drug called abemaciclib before a targeted radiation therapy (177Lu-PSMA-617) can help treat metastatic castration-resistant prostate cancer that has stopped responding to other treatments. Abemaciclib may increase the number of targets (PSMA) on …

This study tests whether adding a drug called apalutamide to standard hormone therapy and radiation can keep prostate cancer from spreading in people whose cancer was found in lymph nodes after prostate removal surgery. About 586 participants will be randomly assigned to get eith…

This study is for men with high-risk prostate cancer that hasn't spread far. It tests whether adding the drug niraparib to standard hormone therapy after radiation can keep the cancer from coming back longer. About 200 participants will receive either hormone therapy alone or hor…

This study is for men with prostate cancer that has spread to other parts of the body. It compares standard drug therapy alone versus standard therapy plus surgery to remove the prostate or radiation to the prostate. The goal is to see if adding local treatment helps patients liv…

This study tests whether adding a targeted drug called talazoparib to standard hormone therapy can better control prostate cancer that has spread but still responds to hormones. About 70 men with metastatic castration-sensitive prostate cancer will receive the combination. The go…

This study tests whether a new type of PET/MRI scan can accurately detect if prostate cancer has spread to nearby lymph nodes. About 50 men with high-risk prostate cancer who are scheduled for prostate removal surgery will receive this scan beforehand. The goal is to see if the s…

This study tests whether freezing bone tumors (cryoablation) before giving radiation therapy works better than radiation alone for reducing pain. About 40 adults with cancer that has spread to the bones will be enrolled. The goal is to see if the combination provides more complet…

This study looks at why some advanced prostate cancers become resistant to a treatment called 177Lu-PSMA. Researchers will take small tissue samples (biopsies) from tumors during treatment to find genetic changes that cause resistance. The goal is to learn how to make treatments …