Vitamin d may shield bones from hormone therapy side effects

NCT ID NCT05838716

Recruiting now Disease control Sponsor: University of Rochester Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase III trial tests whether high-dose vitamin D can prevent bone loss in older men with prostate cancer who are receiving hormone therapy (ADT). The study will enroll 240 men aged 50 and older, giving them either high-dose vitamin D or a placebo for one year. Researchers will measure bone density, falls, and fatigue to see if the supplement helps keep bones strong.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vitamin D
What this could lead to: If it works, this could offer a simple, low-cost way to protect bone health in men undergoing hormone therapy for prostate cancer.
What could go wrong: This is a phase III trial, but vitamin D is already widely available, so the benefit may be modest. The study focuses on bone density, not cancer outcomes, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metastatic prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STAGE I PROSTATE CANCER AJCC V8 STAGE II PROSTATE CANCER AJCC V8 STAGE III PROSTATE CANCER AJCC V8 STAGE IVA PROSTATE CANCER AJCC V8

Contacts and locations

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Locations

Adena Regional Medical Center
RECRUITING

Chillicothe, Ohio, 45601, United States
Ballad Health Cancer Care - Bristol
RECRUITING

Bristol, Virginia, 24201, United States
Ballad Health Cancer Care - Kingsport
RECRUITING

Kingsport, Tennessee, 37660, United States
Bon Secours Cancer Institute at Reynolds Crossing
RECRUITING

Richmond, Virginia, 23230, United States
Bon Secours Memorial Regional Medical Center
RECRUITING

Mechanicsville, Virginia, 23116, United States
Bon Secours Saint Francis Medical Center
RECRUITING

Midlothian, Virginia, 23114, United States
Bon Secours Saint Mary's Hospital
RECRUITING

Richmond, Virginia, 23226, United States
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States
Carilion Roanoke Memorial Hospital
RECRUITING

Roanoke, Virginia, 24033, United States
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact Email: •••••@•••••
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Email: •••••@•••••
CarolinaEast Medical Center
RECRUITING

New Bern, North Carolina, 28561, United States
Community Medical Center
RECRUITING

Scranton, Pennsylvania, 18510, United States

Contact Email: •••••@•••••
Geisinger Cancer Center Dickson City
RECRUITING

Dickson City, Pennsylvania, 18519, United States

Contact Email: •••••@•••••
Geisinger Wyoming Valley/Henry Cancer Center
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States

Contact Email: •••••@•••••
Gibbs Cancer Center-Gaffney
RECRUITING

Gaffney, South Carolina, 29341, United States
Gibbs Cancer Center-Pelham
RECRUITING

Greer, South Carolina, 29651, United States
Gundersen Lutheran Medical Center
RECRUITING

La Crosse, Wisconsin, 54601, United States

Contact Email: •••••@•••••
Helen F Graham Cancer Center
RECRUITING

Newark, Delaware, 19713, United States
Louisiana State University Health Science Center
RECRUITING

New Orleans, Louisiana, 70112, United States
Medical Oncology Hematology Consultants PA
RECRUITING

Newark, Delaware, 19713, United States
Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Saint Louis
RECRUITING

St Louis, Missouri, 63141, United States
Minnesota Oncology Hematology PA-Maplewood
RECRUITING

Maplewood, Minnesota, 55109, United States
Nash UNC HealthCare
RECRUITING

Rocky Mount, North Carolina, 27804, United States
Ochsner Medical Center Jefferson
RECRUITING

New Orleans, Louisiana, 70121, United States
OptumCare Cancer Care at Charleston
RECRUITING

Las Vegas, Nevada, 89102, United States

Contact Email: •••••@•••••
Park Nicollet Clinic - Saint Louis Park
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
Regional Cancer Center at Johnson City Medical Center
RECRUITING

Johnson City, Tennessee, 37604, United States
Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Ridgeview Medical Center
RECRUITING

Waconia, Minnesota, 55387, United States
SMC Center for Hematology Oncology Union
RECRUITING

Union, South Carolina, 29379, United States
Saint Francis Cancer Center
RECRUITING

Greenville, South Carolina, 29607, United States
Saint Francis Hospital
RECRUITING

Greenville, South Carolina, 29601, United States
Saint John's Hospital - Healtheast
RECRUITING

Maplewood, Minnesota, 55109, United States
Saint Vincent Hospital Cancer Center Green Bay
RECRUITING

Green Bay, Wisconsin, 54301, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
RECRUITING

Green Bay, Wisconsin, 54303, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
RECRUITING

Sturgeon Bay, Wisconsin, 54235-1495, United States
Spartanburg Medical Center
RECRUITING

Spartanburg, South Carolina, 29303, United States
University Medical Center New Orleans
RECRUITING

New Orleans, Louisiana, 70112, United States
University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Lee's Summit
RECRUITING

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North
RECRUITING

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center-Overland Park
RECRUITING

Overland Park, Kansas, 66210, United States
University of Kansas Health System Saint Francis Campus
RECRUITING

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
VCU Massey Cancer Center at Stony Point
RECRUITING

Richmond, Virginia, 23235, United States
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States

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