STAGE III PROSTATE CANCER AJCC V8
Clinical trials for STAGE III PROSTATE CANCER AJCC V8 explained in plain language.
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Gene test guides prostate cancer treatment: less or more hormone therapy?
Disease control OngoingThis study tests whether using a genetic test to personalize hormone therapy can improve outcomes for men with high-risk prostate cancer. For those with a low genetic risk, a shorter course of hormone therapy (12 months instead of 24) is compared to standard care. For those with …
Matched conditions: STAGE III PROSTATE CANCER AJCC V8
Phase: PHASE3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated May 17, 2026 02:19 UTC
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Shorter radiation blasts may tame prostate cancer with fewer side effects
Disease control OngoingThis study tests whether a shorter, higher-dose radiation schedule (hypofractionated) works as well as the standard longer course for prostate cancer patients who have had their prostate removed. About 186 men with stage I to IVA prostate cancer will be randomly assigned to one o…
Matched conditions: STAGE III PROSTATE CANCER AJCC V8
Phase: PHASE3 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 15, 2026 11:55 UTC
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Promising prostate cancer combo study pulled before it started
Disease control TerminatedThis study aimed to see if adding the immunotherapy drug pembrolizumab to standard hormone therapy and radiation could improve outcomes for men with high-risk prostate cancer that hasn't spread. It was designed for adults with newly diagnosed, localized disease. However, the stud…
Matched conditions: STAGE III PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: OHSU Knight Cancer Institute • Aim: Disease control
Last updated May 15, 2026 11:54 UTC
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New drug cocktail aims to supercharge immune system against prostate cancer before surgery
Disease control OngoingThis study tests whether a combination of three drugs (enteric-coated aspirin, rintatolimod, and interferon-alpha 2b) can boost the immune system's ability to fight prostate cancer when given before surgery. About 12 men with early-stage prostate cancer who are scheduled for pros…
Matched conditions: STAGE III PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated May 15, 2026 11:53 UTC
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Immunotherapy plus chemo shows promise against Tough-to-Treat cancers
Disease control OngoingThis early-phase trial studies whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can help people with rare, aggressive small cell or neuroendocrine cancers of the bladder or prostate. About 15 participants with cancer that has spread will receive the co…
Matched conditions: STAGE III PROSTATE CANCER AJCC V8
Phase: PHASE1 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Disease control
Last updated May 14, 2026 12:05 UTC
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New combo therapy shows promise for HIV patients with advanced cancer
Disease control OngoingThis early-phase trial is testing the safety of combining two cancer drugs—nivolumab and cabozantinib—in people with HIV who have advanced solid tumors. The study includes 8 participants with various cancers that have spread. The goal is to see if the combination can shrink or st…
Matched conditions: STAGE III PROSTATE CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 11, 2026 20:38 UTC
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New scan could sharpen prostate cancer detection
Diagnosis OngoingThis study tests a special PET scan called 68Ga-PSMA-11 to see if it can find prostate cancer more clearly than standard scans. About 141 men with prostate cancer that has come back or spread will get this scan. The goal is to see if the scan changes how doctors plan treatment, s…
Matched conditions: STAGE III PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: University of Washington • Aim: Diagnosis
Last updated May 17, 2026 02:03 UTC
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Bladder lift may cut incontinence after prostate surgery
Symptom relief TerminatedThis study tests whether adding a procedure called vesicopexy (which repositions the bladder) to standard robotic prostate surgery helps men recover bladder control faster. About 196 men with early-stage prostate cancer will be randomly assigned to get surgery with or without ves…
Matched conditions: STAGE III PROSTATE CANCER AJCC V8
Phase: NA • Sponsor: University of Southern California • Aim: Symptom relief
Last updated May 17, 2026 02:04 UTC
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New lifestyle program aims to boost quality of life for prostate cancer patients and partners
Symptom relief OngoingThis study tests a program called Watchful Living for Black and Hispanic men with early-stage prostate cancer and their partners. The program includes coaching calls and nutrition sessions to help improve quality of life, physical activity, and diet. The goal is to see if this su…
Matched conditions: STAGE III PROSTATE CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated May 15, 2026 11:55 UTC
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Couples' coping: study tracks stress and health in black prostate cancer survivors
Knowledge-focused OngoingThis study looks at how day-to-day stress and social support influence healthy behaviors like exercise and diet in Black prostate cancer survivors and their partners. About 200 couples will use a smartphone app to report their activities and feelings throughout the day. The goal …
Matched conditions: STAGE III PROSTATE CANCER AJCC V8
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 17, 2026 02:18 UTC
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Can a Couples' lifestyle program reduce prostate cancer disparities?
Knowledge-focused OngoingThis study tests a lifestyle program for African American men who have finished prostate cancer treatment and their spouses or partners. The goal is to see if the program helps improve quality of life, partner support, physical activity, and diet. Only 6 couples are taking part, …
Matched conditions: STAGE III PROSTATE CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 17, 2026 02:04 UTC
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New study aims to protect hearts during prostate cancer treatment
Knowledge-focused OngoingThis study looks at how hormone therapy for prostate cancer can affect the heart. Researchers are comparing two drugs, leuprolide and relugolix, to see which one is safer for the heart. About 94 men with non-spreading prostate cancer will take part. The goal is to find better way…
Matched conditions: STAGE III PROSTATE CANCER AJCC V8
Phase: PHASE2 • Sponsor: Emory University • Aim: Knowledge-focused
Last updated May 14, 2026 12:05 UTC