STAGE III PROSTATE CANCER AJCC V8

This phase 3 trial tests whether treatment for high-risk prostate cancer can be personalized based on a patient's genetic risk score. For those with a low genetic risk, a shorter course of hormone therapy plus radiation may be as effective as the standard 24-month treatment, with…

This phase III trial tests whether adding the drug apalutamide to standard hormone therapy and radiation helps men with prostate cancer that has spread to nearby lymph nodes after surgery. About 586 participants will receive either the usual treatment or the usual treatment plus …

This phase 2 trial tests whether giving a combination of enteric-coated aspirin, rintatolimod, and interferon-alpha 2b before prostate cancer surgery can boost the immune system's attack on tumors. The study involves 12 men with localized prostate cancer who are scheduled for sur…

This early-phase trial tests the safety of combining two cancer drugs, nivolumab and cabozantinib, in people with HIV who have advanced solid tumors. Only 8 participants were enrolled. The goal is to see if the combination is safe and can shrink or stabilize tumors.

This phase 3 trial tests whether a shorter, higher-dose radiation schedule (hypofractionated) works as well as the standard longer course for men with prostate cancer who have had surgery. About 186 men will be randomly assigned to one of the two radiation plans. The study tracks…

This early-phase trial tests whether adding the immunotherapy drug pembrolizumab to standard platinum-based chemotherapy can help people with rare, aggressive small cell or neuroendocrine cancers of the bladder or prostate. The study includes 15 participants whose cancer has spre…

This study was designed to test whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard hormone therapy and radiation could improve outcomes for men with high-risk localized prostate cancer. The trial was withdrawn before enrolling any participants, so no resul…

This study tests whether a special PET scan using a tracer called 68Ga-PSMA-11 can find prostate cancer more clearly than standard scans. About 141 men with prostate cancer at different stages will get the scan. The goal is to see if the scan changes how doctors plan treatment, s…

This phase II trial tests whether time-restricted eating (intermittent fasting) can reduce side effects from radiation or chemoradiation in people with prostate, cervical, or rectal cancers. About 49 participants will either follow a time-restricted eating plan or receive standar…

This study compares standard robotic prostate cancer surgery with or without an extra step called vesicopexy, which repositions the bladder to its normal place. The goal is to see if this addition helps men regain bladder control faster and improves their quality of life. About 1…

This pilot study tests a lifestyle intervention called Watchful Living for Black and Hispanic prostate cancer patients on active surveillance and their partners. The program includes nutrition counseling, an exercise plan, and telephone coaching to improve quality of life, physic…

This study tests a lifestyle program for African American men who have finished prostate cancer treatment and their spouses or partners. The goal is to see if the program can improve quality of life, diet, physical activity, and partner support. Only 6 participants were enrolled,…

This study looks at how certain hormone therapies for prostate cancer affect the heart. It compares two drugs, leuprolide and relugolix, given alongside radiation. The goal is to understand why some men develop heart problems and find ways to predict and reduce that risk. About 9…

This study follows 200 African American prostate cancer survivors and their partners to understand how daily stress, social support, and lifestyle choices like physical activity and diet affect each other. Participants wear an activity tracker and answer surveys on their smartpho…