STAGE III PROSTATE CANCER AJCC V8

This large study aims to personalize treatment for men with high-risk prostate cancer. Based on a genetic test score, patients receive either a shorter course of hormone therapy (to reduce side effects) or a stronger hormone therapy regimen (to better control aggressive cancer), …

This early-stage trial is testing whether adding the immunotherapy drug pembrolizumab to standard chemotherapy works better for treating advanced small cell or neuroendocrine cancers of the bladder, urethra, or prostate. The study will enroll about 15 participants with cancer tha…

This study is testing if giving testosterone replacement therapy (TRT) to men with low testosterone and early-stage prostate cancer is safe and improves their quality of life. The men are on 'active surveillance,' which means their cancer is being closely monitored instead of bei…

This study compares two radiation schedules given after prostate cancer surgery. It tests whether a shorter, more intense 4.5-week course works as well as the standard 7-week course at keeping cancer from returning. Researchers will track side effects and quality of life for up t…

This study aimed to see if adding the immunotherapy drug pembrolizumab to standard hormone therapy and radiation could better eliminate cancer in men with high-risk prostate cancer that hasn't spread. The main goal was to check if a follow-up biopsy showed no cancer after treatme…

This early-stage study is testing a new combination of two drugs, AZD8186 and docetaxel, for patients with advanced solid tumors that have specific genetic changes (PTEN or PIK3CB mutations). The main goals are to find the safest and most effective dose and to understand the side…

This is a small, early-stage safety study testing a combination of two cancer drugs, nivolumab and cabozantinib, in people living with HIV who have advanced solid tumors. The main goal is to see if the two-drug combination is safe and tolerable for this specific patient group. Re…

This study is testing a personalized treatment method for people with advanced breast, prostate, ovarian, pancreatic, or sarcoma cancers that have spread. Doctors analyze each patient's tumor using genetic and protein tests to understand how the cancer is changing and which drugs…

This study is testing a new type of PET scan called 68Ga-PSMA-11 to see if it can better find and track prostate cancer. It enrolled 141 men with different stages of prostate cancer to see if this scan changes how doctors plan their treatment. The goal is to improve how doctors m…

This study is testing a lifestyle support program called 'Watchful Living' for Black and Hispanic men with early-stage prostate cancer who are on active surveillance (watching and waiting) and their partners. The program provides phone coaching on exercise and nutrition over six …

This study compares two versions of robotic prostate cancer surgery to see if adding a bladder-supporting stitch helps men regain bladder control faster. About 200 men with early-stage prostate cancer will be randomly assigned to receive the standard surgery or the surgery with t…

This study is testing a lifestyle program designed for African American men who have finished treatment for prostate cancer and their spouses or partners. The goal is to see if working together as a couple can help improve quality of life, increase physical activity, and encourag…

This study aims to understand how certain prostate cancer hormone treatments affect heart health. It will compare two different hormone drugs given alongside radiation therapy to see which might be safer for the heart. Researchers will use heart scans and blood tests to learn why…

This study aims to understand the daily ups and downs of stress, social support, and healthy habits like exercise and diet in Black men who have survived prostate cancer and their partners. Researchers are observing how couples cope with stress together and how that affects their…