ADVANCED MALIGNANT SOLID NEOPLASM
Clinical trials for ADVANCED MALIGNANT SOLID NEOPLASM explained in plain language.
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Groundbreaking pill trial offers hope for tough liver cancers
Disease control Recruiting nowThis is the first human study of an experimental oral medication called AU409 for people with advanced liver cancers or other solid tumors that have spread to the liver. The main goal is to find the safest and most effective dose by testing it in a small group of patients whose c…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: University of Southern California • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Scientists test three new drug cocktails in fight against advanced cancers
Disease control Recruiting nowThis early-stage trial is testing three different drug combinations to find safe doses and see if they can help control advanced solid tumors that have spread. The study will enroll about 111 adults with specific genetic features in their cancer. Researchers aim to see if combini…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Apr 01, 2026 14:40 UTC
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New drug duo aims to halt advanced cancers by targeting their genetic weaknesses
Disease control Recruiting nowThis study is testing whether a combination of two oral drugs, ZEN-3694 and talazoparib, can shrink or stop the growth of advanced solid tumors that have specific genetic features. It aims to enroll 88 adults whose cancer has progressed despite prior treatments. A key goal is to …
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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New hope for tough cancers: experimental drug enters first human testing
Disease control Recruiting nowThis is the first human study of a new chemotherapy drug called TR-002. It aims to find the safest dose and understand side effects for people with advanced solid tumors, including pancreatic cancer, that have stopped responding to standard treatments. The study will enroll 52 pa…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: University of California, Davis • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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New Triple-Threat cancer therapy enters human testing
Disease control Recruiting nowThis study is testing whether combining three different cancer drugs is safe and effective for treating advanced solid tumors that have spread or returned after standard treatments. The three drugs work in different ways: one helps the immune system attack cancer, one blocks tumo…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1, PHASE2 • Sponsor: OHSU Knight Cancer Institute • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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New weapon against advanced cancer: trial tests Three-Pronged attack
Disease control Recruiting nowThis study is testing a new three-part treatment for patients with advanced cancer that has spread to the lungs or liver. The goal is to see if a drug called NBTXR3, which is injected directly into a tumor, makes cancer cells more sensitive to radiation. Patients also receive an …
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Major trial uses genetic blueprint to find the right drug combo for advanced cancer
Disease control Recruiting nowThis trial is a large screening program that matches patients with advanced solid tumors to one of many smaller treatment studies. It uses genetic testing on a patient's tumor to find specific mutations. Patients are then assigned to a drug combination designed to target those mu…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Cancer care comes home: mayo clinic tests house calls for treatment
Disease control Recruiting nowThis study is testing whether giving standard cancer treatments at home is as safe and effective as giving them in a clinic. It aims to see if receiving care at home reduces stress, improves quality of life, and is preferred by patients with advanced cancers. About 220 participan…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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New drug duo targets Tough-to-Treat cancers
Disease control Recruiting nowThis study is testing the safety and effectiveness of a new two-drug combination for people with advanced solid tumors, including pancreatic cancer, that have spread or stopped responding to standard treatments. The trial aims to find the best dose and see if the drugs can help c…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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Scientists test 'One-Two Punch' against Tough-to-Treat cancers
Disease control Recruiting nowThis early-stage study is testing the safety and best dose of a new two-drug combination for people with advanced solid tumors that have a specific marker called HER2. The treatment pairs an existing targeted cancer drug with a new pill that aims to block cancer cells' ability to…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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New cancer drug trial seeks to control advanced tumors
Disease control Recruiting nowThis early-stage trial is testing a new drug called CBX-12 in patients with advanced solid tumors that have spread to other parts of the body. The drug works by damaging cancer cell DNA to kill tumors. Researchers will study how the drug affects cancer cells, measure tumor respon…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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New pill targets tough cancers in early safety trial
Disease control Recruiting nowThis is a first-in-human study to find a safe dose of a new oral drug called IACS-6274. It will be tested alone and in two different drug combinations in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check the safety …
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 24, 2026 12:03 UTC
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New drug duo aims to outsmart tough cancers
Disease control Recruiting nowThis study is testing if adding a second drug (panitumumab) to a targeted cancer pill (sotorasib) works better than the pill alone for patients with advanced solid tumors that have a specific KRAS G12C mutation. It is for people whose cancer has spread and who have already tried …
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 23, 2026 15:19 UTC
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New drug duo tested to fight advanced GI cancers
Disease control Recruiting nowThis early-stage study aims to find the safest and most effective dose of a new two-drug combination for people with advanced colorectal or gastroesophageal (stomach/esophagus) cancers that have spread. The trial will enroll about 45 adults whose cancer has progressed after at le…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Mar 23, 2026 15:16 UTC
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New approach aims to shield patients from dangerous side effects when restarting cancer treatment
Disease control Recruiting nowThis study is testing whether adding a drug called siltuximab can help cancer patients safely restart a type of immunotherapy that previously caused them severe side effects. The trial will enroll 40 adults with advanced cancer who had to stop their original immunotherapy due to …
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: Yuanquan Yang • Aim: Disease control
Last updated Mar 23, 2026 15:16 UTC
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Scientists test novel drug duo to halt advanced cancers
Disease control Recruiting nowThis early-stage trial is testing a new combination of two oral drugs, peposertib and tuvusertib, in adults with advanced solid tumors that have spread and stopped responding to standard treatments. The main goals are to find the safest and most effective dose of the drug pair an…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 16, 2026 15:26 UTC
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New pill targets 'Undruggable' cancer driver in desperate patients
Disease control Recruiting nowThis early-stage trial is testing a new oral drug called RSC-1255 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how well the drug is tolerated, both alone and combined with another medicati…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: RasCal Therapeutics, Inc. • Aim: Disease control
Last updated Mar 16, 2026 15:24 UTC
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First human test for promising new cancer pill
Disease control Recruiting nowThis is an early safety study for a new drug called TAK-243 in adults with advanced solid tumors or lymphoma. The main goal is to find the safest dose and understand the side effects. Researchers will give the drug to about 95 patients and closely monitor how their bodies handle …
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 16, 2026 15:23 UTC
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Cancer trial matches patients to targeted drugs based on tumor markers
Disease control Recruiting nowThis study aims to see if matching patients to one of three targeted cancer drugs works better for treating advanced solid tumors. It will enroll 500 adults whose cancer has spread and who have specific proteins (Trop-2, nectin-4, or HER2) in their tumor. Patients will first be s…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Feb 27, 2026 15:19 UTC
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Scientists test new drug duo to attack advanced cancers
Disease control Recruiting nowThis early-phase trial is testing a new combination of two drugs, temozolomide and M1774, for people with advanced cancers that have spread. The main goals are to find the safest and most effective dose and to see if the combination can shrink or stabilize tumors, especially in a…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Feb 25, 2026 15:07 UTC
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Could a common drug help cancer patients regain lost weight?
Symptom relief Recruiting nowThis study is testing whether olanzapine, a medication that affects brain chemicals, can help cancer patients who are losing too much weight and have poor appetite. The trial will involve 66 adults with advanced cancers of the stomach, liver, pancreas, colon, or lung who have los…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: OHSU Knight Cancer Institute • Aim: Symptom relief
Last updated Apr 01, 2026 14:41 UTC
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Could a Fasting-Mimicking diet shield cancer patients from harsh treatment side effects?
Symptom relief Recruiting nowThis small pilot study from the Mayo Clinic is testing whether a specific, low-calorie diet can help reduce the side effects that cancer patients often experience during immunotherapy. The diet, which includes soups, bars, and teas, is designed to mimic the effects of fasting. Re…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: NA • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Mar 31, 2026 12:12 UTC
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New hope for cancer patients struggling to eat: major trial tests common drug against standard treatment
Symptom relief Recruiting nowThis study compares two medications—olanzapine and megestrol acetate—to see which works better at improving appetite and preventing weight loss in people with advanced cancer. Researchers will enroll 360 patients who have lost weight and have poor appetite due to their cancer. Pa…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Symptom relief
Last updated Mar 13, 2026 15:05 UTC
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Can video calls train doctors to give better comfort care to dying patients?
Knowledge-focused Recruiting nowThis study is testing if a special online training program (called Project ECHO) can help doctors and nurses in rural and underserved areas provide better comfort and symptom care (palliative care) for people with advanced cancer. It will measure if patients' quality of life and …
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:28 UTC
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Helping young cancer patients plan for their future care
Knowledge-focused Recruiting nowThis study is testing whether educational videos and guided appointments help young adults (ages 18-39) with advanced cancer have better conversations about their future medical care preferences. Researchers want to see if these tools make it easier for patients to discuss and do…
Matched conditions: ADVANCED MALIGNANT SOLID NEOPLASM
Phase: NA • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Mar 09, 2026 14:26 UTC