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New drug combo aims to shrink Hard-to-Treat tumors

NCT ID NCT05053971

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two experimental drugs, ZEN003694 and entinostat, in people with advanced or treatment-resistant solid tumors, including pancreatic cancer. The goal is to find the safest dose and see if the combination can shrink tumors. About 49 participants will take part in this early-phase trial.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

B-cell non-Hodgkin lymphoma cancer exocrine pancreatic carcinoma lymphoma malignant pancreatic neoplasm neoplasm pancreatic adenocarcinoma pancreatic neoplasm refractory malignant neoplasm T-cell non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED LYMPHOMA ADVANCED MALIGNANT SOLID NEOPLASM ADVANCED PANCREATIC CARCINOMA B-CELL NON-HODGKIN LYMPHOMA LOCALLY ADVANCED PANCREATIC CARCINOMA METASTATIC PANCREATIC CARCINOMA REFRACTORY B-CELL NON-HODGKIN LYMPHOMA REFRACTORY LYMPHOMA REFRACTORY MALIGNANT SOLID NEOPLASM REFRACTORY PANCREATIC CARCINOMA REFRACTORY T-CELL NON-HODGKIN LYMPHOMA STAGE II PANCREATIC CANCER AJCC V8 STAGE III PANCREATIC CANCER AJCC V8 STAGE IV PANCREATIC CANCER AJCC V8 UNRESECTABLE PANCREATIC CARCINOMA

Contacts and locations

Locations

  • UF Health Cancer Institute - Gainesville

    RECRUITING

    Gainesville, Florida, 32610, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Oklahoma Health Sciences Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06520, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••