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New drug cocktail aims to shrink Hard-to-Treat tumors

NCT ID NCT05327010

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 7 times

Summary

This study tests whether a combination of two drugs (ZEN003694 and talazoparib) can shrink tumors in people with advanced solid cancers that have stopped responding to standard treatments. About 88 adults will take part. Researchers will also look at participants' genes to see if they affect how well the treatment works.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer metastatic malignant neoplasm neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED MALIGNANT SOLID NEOPLASM METASTATIC MALIGNANT SOLID NEOPLASM UNRESECTABLE MALIGNANT SOLID NEOPLASM

Contacts and locations

Locations

  • City of Hope Comprehensive Cancer Center

    SUSPENDED

    Duarte, California, 91010, United States

  • City of Hope at Irvine Lennar

    SUSPENDED

    Irvine, California, 92618, United States

  • Emory University Hospital/Winship Cancer Institute

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Huntsman Cancer Institute/University of Utah

    ACTIVE_NOT_RECRUITING

    Salt Lake City, Utah, 84112, United States

  • Keck Medicine of USC Koreatown

    ACTIVE_NOT_RECRUITING

    Los Angeles, California, 90020, United States

  • Los Angeles General Medical Center

    ACTIVE_NOT_RECRUITING

    Los Angeles, California, 90033, United States

  • National Cancer Institute Developmental Therapeutics Clinic

    RECRUITING

    Bethesda, Maryland, 20892, United States

  • National Institutes of Health Clinical Center

    ACTIVE_NOT_RECRUITING

    Bethesda, Maryland, 20892, United States

  • Northwestern University

    RECRUITING

    Chicago, Illinois, 60611, United States

    Contact Email: •••••@•••••

  • Ochsner Medical Center Jefferson

    RECRUITING

    New Orleans, Louisiana, 70121, United States

  • Smilow Cancer Hospital Care Center-Trumbull

    ACTIVE_NOT_RECRUITING

    Trumbull, Connecticut, 06611, United States

  • UC San Diego Medical Center - Hillcrest

    RECRUITING

    San Diego, California, 92103, United States

  • UC San Diego Moores Cancer Center

    RECRUITING

    La Jolla, California, 92093, United States

    Contact Email: •••••@•••••

  • UCHealth University of Colorado Hospital

    ACTIVE_NOT_RECRUITING

    Aurora, Colorado, 80045, United States

  • UF Health Cancer Institute - Gainesville

    ACTIVE_NOT_RECRUITING

    Gainesville, Florida, 32610, United States

  • UNC Lineberger Comprehensive Cancer Center

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

    Contact Email: •••••@•••••

  • UPMC Hillman Cancer Center

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • USC / Norris Comprehensive Cancer Center

    ACTIVE_NOT_RECRUITING

    Los Angeles, California, 90033, United States

  • USC Norris Oncology/Hematology-Newport Beach

    ACTIVE_NOT_RECRUITING

    Newport Beach, California, 92663, United States

  • UT MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • University of California Davis Comprehensive Cancer Center

    ACTIVE_NOT_RECRUITING

    Sacramento, California, 95817, United States

  • University of Kansas Cancer Center

    RECRUITING

    Kansas City, Kansas, 66160, United States

  • University of Kansas Cancer Center - Lee's Summit

    RECRUITING

    Lee's Summit, Missouri, 64064, United States

  • University of Kansas Cancer Center - North

    RECRUITING

    Kansas City, Missouri, 64154, United States

  • University of Kansas Cancer Center at North Kansas City Hospital

    SUSPENDED

    North Kansas City, Missouri, 64116, United States

  • University of Kansas Cancer Center-Overland Park

    RECRUITING

    Overland Park, Kansas, 66210, United States

  • University of Kansas Clinical Research Center

    RECRUITING

    Fairway, Kansas, 66205, United States

  • University of Kansas Hospital-Indian Creek Campus

    RECRUITING

    Overland Park, Kansas, 66211, United States

  • University of Kansas Hospital-Westwood Cancer Center

    RECRUITING

    Westwood, Kansas, 66205, United States

  • University of Kentucky/Markey Cancer Center

    RECRUITING

    Lexington, Kentucky, 40536, United States

  • University of Texas Health Science Center at San Antonio

    WITHDRAWN

    San Antonio, Texas, 78229, United States

  • University of Texas Medical Branch

    RECRUITING

    Galveston, Texas, 77555-0565, United States

    Contact Email: •••••@•••••

  • University of Texas at Austin

    ACTIVE_NOT_RECRUITING

    Austin, Texas, 78712, United States

  • University of Virginia Cancer Center

    RECRUITING

    Charlottesville, Virginia, 22908, United States

    Contact Email: •••••@•••••

  • VCU Massey Comprehensive Cancer Center

    RECRUITING

    Richmond, Virginia, 23298, United States

  • Yale University

    ACTIVE_NOT_RECRUITING

    New Haven, Connecticut, 06520, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.