Can a Custom-Made immune cell vaccine turn the tide against solid tumors?
NCT ID NCT07752953
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This trial tests a personalized approach to treating advanced solid tumors. Doctors take a patient's own immune cells, train them to recognize that patient's specific cancer mutations, and inject them back under the skin. The goal is to see if these customized cells can safely trigger a stronger immune attack on the tumor, either alone or alongside standard immunotherapy drugs. Around 100 adults with various advanced solid tumors will receive seven injections over about two months, and researchers will track tumor response, survival, and side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Personalized neoantigen-pulsed autologous dendritic cell injections (ZSNeo-DC), a cell therapy made from the patient's own immune cells, given alone or with immune checkpoint inhibitors.
- What this could lead to
- If successful, this personalized cell therapy could offer a new way to control advanced solid tumors by training the immune system to target each patient's unique cancer mutations.
- What could go wrong
- This is an early, real-world study without a control group, so results may not prove effectiveness. Side effects from the cell injections or combination with checkpoint inhibitors are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Beidaihe Hospital of Qinhuangdao
RECRUITINGQinhuangdao, Hebei, 066100, China
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