New drug cocktail aims to outsmart advanced cancers
NCT ID NCT04693468
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing whether combining the drug talazoparib with one of three other drugs (palbociclib, axitinib, or crizotinib) can safely help control advanced solid tumors that have spread. Talazoparib blocks cancer cells from repairing their DNA, while the other drugs target different growth signals. The study involves about 111 participants and focuses on finding the best doses and understanding side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Talazoparib combined with palbociclib, axitinib, or crizotinib
- What this could lead to
- If successful, this could point toward new combination treatments that help control advanced solid tumors by blocking cancer cell repair and growth.
- What could go wrong
- This is an early phase 1 trial with a small number of participants, so it may not lead to a proven treatment. Side effects from the drug combinations are possible and will be closely monitored.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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