Nanoparticles boost radiation to fight advanced cancer in new trial
NCT ID NCT05039632
First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 5 times
Summary
This phase I/II trial tests whether injecting NBTXR3 nanoparticles into tumors can make radiation more effective, combined with immunotherapy (anti-PD-1/PD-L1), for patients with advanced solid cancers that have spread to the lung or liver. The study aims to see if this approach can shrink tumors and control the disease. About 40 participants will receive the treatment, and researchers will monitor side effects and tumor response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- NBTXR3 nanoparticles (hafnium oxide) injected into tumors, plus radiation therapy and anti-PD-1/PD-L1 immunotherapy (e.g., nivolumab)
- What this could lead to
- If successful, this could offer a new way to control advanced cancers that have spread to the lung or liver, potentially shrinking tumors and extending life.
- What could go wrong
- This is an early phase I/II trial with only 40 participants, so results are preliminary. The combination may cause serious side effects, and not all patients may respond.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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