Can a smart drug deliver a toxic payload directly to cancer cells?
NCT ID NCT07726212
First seen Jul 24, 2026 · Last updated Jul 28, 2026 · Updated 2 times
Summary
This early-phase trial is testing an experimental antibody-drug conjugate called MC002 in adults with advanced solid tumors, such as esophageal or lung cancer, that have progressed after standard treatments. MC002 is designed to target a protein found on cancer cells and deliver a chemotherapy-like payload directly to them. The study aims to find a safe dose and see whether the drug shrinks tumors.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- an antibody-drug conjugate called MC002 that targets a protein found on cancer cells
- What this could lead to
- If successful, this could point toward a new treatment option for people with advanced solid tumors that have stopped responding to standard therapies.
- What could go wrong
- This is a very early, first-in-human trial, so the drug may not be safe or effective. Side effects from the antibody-drug conjugate could be serious.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
-
About 143 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Sep 2026
An estimate. Start dates often move.
- Expected to finish
-
Jun 2028
An estimate. End dates often move.
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 18 years of age and over, male or female, able to understand and willing to sign the Informed Consent Form (ICF). * Life expectancy of 3 month or greater * participants with histologically or cytologically confirmed recurrent or metastatic unresectable advanced solid tumors who experience disease progression after receiving systemic standard therapy, or have no standard therapy. * At least one measurable lesion as assessed by RECIST 1.1 * Adequate organ functions. * ECOG Performance Status (PS) of 0-1 Exclusion Criteria: * Pregnant or nursing females.Participants who have received chemotherapy, investigational therapy, immunotherapy, or any other antitumor active drugs within 4 weeks or 5 half-lives (whichever is shorter) before the first dose. * Known hypersensitivity to either the drug substances or inactive ingredient * Participants who have undergone a bone marrow transplantation, solid organ transplantation, stem cell transplant. * Participants with QTc \>470 msec. * Use of ≥10 mg of prednisone or equivalent dose of steroids per day within 3 months of administration (inhaled, intranasal, intraocular, topical and intraarticular joint injections of corticosteroids are allowed).Participants with a history of HCV infection who have not completed curative anti HCV treatment and whose HCV load is above the limit of quantification. Concurrent HCV treatment is not allowed in the trial.Live viral vaccine therapies within 4 weeks prior to the first dose of study drug. * Participants who have received treatment with any herbal or alternative therapies within 7 days prior to the first dose of the study drug. * Male and female participants of childbearing potential must be willing to completely abstain or agree to use a highly effective method of contraception
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Advanced esophageal cancer are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A new tool aims to demystify immunotherapy for advanced cancer patients
- A 17-point quiz may reveal which older cancer patients need extra care
- Can a new pill outsmart RAS-Mutant cancers?
- Could a personal coach at home boost energy for cancer patients?
- Personalized maintenance therapy: a smarter way to treat advanced cancer?
- Can a radioactive antibody light up hidden cancers on PET scans?