New trial matches cancer patients to smart drug bombs
NCT ID NCT06311214
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial is testing whether three antibody-drug conjugates (ADCs) can shrink advanced or metastatic solid tumors that have high levels of specific proteins (Trop-2, nectin-4, or HER2). About 500 patients will first have their tumors tested for these markers, then receive the matching ADC. The goal is to see if this personalized approach improves response rates.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sacituzumab govitecan, enfortumab vedotin, trastuzumab deruxtecan
- What this could lead to
- If successful, this could show that matching these antibody-drug conjugates to specific protein markers on tumors is an effective treatment for advanced or metastatic solid cancers.
- What could go wrong
- This is a phase II trial, so it is still early. The drugs may not work for many patients, and side effects from the chemotherapy-like drugs can be serious. Results may not apply to all cancer types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope Comprehensive Cancer Center
RECRUITINGDuarte, California, 91010, United States
Contact
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City of Hope at Irvine Lennar
RECRUITINGIrvine, California, 92618, United States
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
RECRUITINGNew York, New York, 10032, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ochsner Medical Center Jefferson
RECRUITINGNew Orleans, Louisiana, 70121, United States
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Siteman Cancer Center at Christian Hospital
RECRUITINGSt Louis, Missouri, 63136, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Siteman Cancer Center at Saint Peters Hospital
RECRUITINGCity of Saint Peters, Missouri, 63376, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Siteman Cancer Center at West County Hospital
RECRUITINGCreve Coeur, Missouri, 63141, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Siteman Cancer Center-South County
RECRUITINGSt Louis, Missouri, 63129, United States
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Smilow Cancer Hospital Care Center-Trumbull
RECRUITINGTrumbull, Connecticut, 06611, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UC San Diego Health System - Encinitas
RECRUITINGEncinitas, California, 92024, United States
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UC San Diego Medical Center - Hillcrest
RECRUITINGSan Diego, California, 92103, United States
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UC San Diego Moores Cancer Center
RECRUITINGLa Jolla, California, 92093, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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UF Health Cancer Institute - Gainesville
RECRUITINGGainesville, Florida, 32610, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UT MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Kentucky/Markey Cancer Center
RECRUITINGLexington, Kentucky, 40536, United States
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Virginia Cancer Center
RECRUITINGCharlottesville, Virginia, 22908, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
RECRUITINGMadison, Wisconsin, 53718, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITINGMadison, Wisconsin, 53792, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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VCU Massey Comprehensive Cancer Center
RECRUITINGRichmond, Virginia, 23298, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vanderbilt Breast Center at One Hundred Oaks
RECRUITINGNashville, Tennessee, 37204, United States
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Vanderbilt University/Ingram Cancer Center
RECRUITINGNashville, Tennessee, 37232, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Yale University
RECRUITINGNew Haven, Connecticut, 06520, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Other studies related to the condition(s) this trial covers.
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