New combo therapy aims to supercharge immune attack on tough cancers
NCT ID NCT04021043
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a combination of three immunotherapy drugs (ipilimumab, nivolumab, and BMS-986156) with or without precise radiation therapy in 51 people with advanced solid cancers that had spread to the liver or lungs. The goal was to find the safest dose of BMS-986156 and see if adding radiation helps the immune system fight tumors better. The trial is complete, but results are not yet reported.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Immunotherapy drugs (ipilimumab, nivolumab, BMS-986156) and stereotactic body radiation therapy
- What this could lead to
- If it works, this could point toward a more effective treatment combination for advanced cancers that have spread to the liver or lungs.
- What could go wrong
- This is an early-phase trial with only 51 participants, so results may not apply to everyone. The combination may cause significant side effects or not improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
Houston, Texas, 77030, United States
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