Immunotherapy shows promise for Hard-to-Treat cancers with specific gene mutations

NCT ID NCT03428802

First seen Apr 09, 2026 · Last updated Apr 29, 2026 · Updated 3 times

Summary

This study tested the drug pembrolizumab (a type of immunotherapy) in 21 adults with advanced solid tumors that have specific gene mutations (BRCA1, BRCA2, POLE, or POLD1). The goal was to see if the drug could shrink or control the cancer. Participants received pembrolizumab intravenously, and their tumors were measured using scans. The study is no longer recruiting, and results are being analyzed.

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Contacts and locations

Locations

  • Laura & Isaac Perlmutter Cancer Center at NYU Langone Health

    New York, New York, 10016, United States

  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey, 08903, United States

Conditions

Explore the condition pages connected to this study.