New radiation approach targets multiple tumors at once in early trial

NCT ID NCT02206334

Completed Knowledge-focused Sponsor: NRG Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tested a precise, high-dose radiation technique called stereotactic body radiotherapy (SBRT) in 42 patients with breast, lung, or prostate cancer that had spread to several places in the body. The main goal was to find the safest dose and check for side effects when treating multiple tumor sites at the same time. The study did not aim to cure or control the disease, but to gather safety information for future research.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Stereotactic body radiation therapy (SBRT)

What this could lead to

If successful, this could help determine safe radiation doses for treating multiple cancer spread sites at once, potentially improving treatment options.

What could go wrong

This is an early phase 1 trial with only 42 participants, focused on safety and dosing, not effectiveness. Results may not apply to all patients or cancer types.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm male breast carcinoma metastatic prostate carcinoma non-small cell lung carcinoma prostate adenocarcinoma prostate cancer prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MALE BREAST CARCINOMA PROSTATE ADENOCARCINOMA RECURRENT BREAST CARCINOMA RECURRENT NON-SMALL CELL LUNG CARCINOMA RECURRENT PROSTATE CARCINOMA STAGE IV BREAST CANCER STAGE IV NON-SMALL CELL LUNG CANCER STAGE IV PROSTATE CANCER

Contacts and locations

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Locations

Arizona Center for Cancer Care-Peoria

Peoria, Arizona, 85381, United States
Ascension Saint Vincent Anderson

Anderson, Indiana, 46016, United States
Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214, United States
Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States
Boston Medical Center

Boston, Massachusetts, 02118, United States
CHUM - Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, H2X 3E4, Canada
City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Community Medical Center

Toms River, New Jersey, 08755, United States
Cooper CyberKnife Center

Mount Laurel, New Jersey, 08054, United States
Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Delaware County Memorial Hospital

Drexel Hill, Pennsylvania, 19026, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Grady Health System

Atlanta, Georgia, 30303, United States
Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
IU Health Methodist Hospital

Indianapolis, Indiana, 46202, United States
Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States
Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada
Kantonsspital Aarau

Aarau, 5001, Switzerland
Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
McLaren Cancer Institute-Flint

Flint, Michigan, 48532, United States
McLaren Cancer Institute-Macomb

Mount Clemens, Michigan, 48043, United States
McLaren Cancer Institute-Northern Michigan

Petoskey, Michigan, 49770, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Michigan Healthcare Professionals Clarkston

Clarkston, Michigan, 48346, United States
Michigan Healthcare Professionals Farmington

Farmington Hills, Michigan, 48334, United States
Michigan Healthcare Professionals Troy

Troy, Michigan, 48098, United States
Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States
Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States
Northwest Community Hospital

Arlington Heights, Illinois, 60005, United States
Northwestern University

Chicago, Illinois, 60611, United States
OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States
Ogden Regional Medical Center

Ogden, Utah, 84405, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Parkview Hospital Randallia

Fort Wayne, Indiana, 46805, United States
Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States
Reading Hospital

West Reading, Pennsylvania, 19611, United States
Self Regional Healthcare

Greenwood, South Carolina, 29646, United States
Southwest Illinois Health Services LLP

Swansea, Illinois, 62226, United States
Springfield Memorial Hospital

Springfield, Illinois, 62781, United States
Sutter Medical Center Sacramento

Sacramento, California, 95816, United States
The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202, United States
Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
UF Health Cancer Institute - Gainesville

Gainesville, Florida, 32610, United States
UM Upper Chesapeake Medical Center

Bel Air, Maryland, 21014, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States
University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States
University of Florida Health Science Center - Jacksonville

Jacksonville, Florida, 32209, United States
University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States
University of Rochester

Rochester, New York, 14642, United States
Virtua Memorial

Mount Holly, New Jersey, 08060, United States
Virtua Voorhees

Voorhees Township, New Jersey, 08043, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Walter Reed National Military Medical Center

Bethesda, Maryland, 20889-5600, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Zablocki Veterans Administration Medical Center

Milwaukee, Wisconsin, 53295, United States