One shot of radiation could replace weeks of treatment for some breast cancers
NCT ID NCT05350722
First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time
Summary
This trial investigates whether a single, high dose of MRI-guided radiation given before surgery can completely eliminate low-risk breast cancer. Women aged 50 and older with small, early-stage tumors receive one radiation dose, then wait 6 to 12 months before surgery to see if the cancer is gone. The goal is to find a simpler, less invasive treatment option that might avoid the need for standard radiation or even surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- single dose ablative radiotherapy
- What this could lead to
- If successful, this approach could allow some low-risk breast cancer patients to avoid surgery or standard radiation, reducing treatment burden.
- What could go wrong
- This is an early-phase trial with only 100 participants, so results may not apply broadly. The single dose may not fully eliminate the tumor, and long-term safety is unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Amsterdam UMC
RECRUITINGAmsterdam, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Canisius Wilhelmina Ziekenhuis
RECRUITINGNijmegen, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Flevoziekenhuis
RECRUITINGAlmere Stad, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GenesisCare
NOT_YET_RECRUITINGSydney, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Radboud UMC
RECRUITINGNijmegen, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Zaans Medisch Centrum
RECRUITINGZaandam, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ziekenhuis Amstelland
RECRUITINGAmstelveen, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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