Can brain scans and voice recordings predict the best depression treatment?

NCT ID NCT04480918

Recruiting now Knowledge-focused Sponsor: Mark Niciu Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is a registry that will follow up to 1,000 adults with treatment-resistant depression or obsessive-compulsive disorder (OCD) who receive electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), or ketamine/esketamine. Researchers will collect data from brain scans, cognitive tests, voice recordings, and genetic tests before, during, and after treatment. The goal is to find biological markers that can predict which therapy works best for each person, moving toward personalized psychiatry.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), ketamine, esketamine
What this could lead to: If successful, this could help doctors choose the best treatment for each patient with depression or OCD, making care more personalized.
What could go wrong: This is an observational registry, not a controlled trial, so it cannot prove which treatment works best. Results may take years and might not change practice directly.

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Conditions

The condition(s) this trial relates to.

bipolar depression bipolar disorder Depressive Disorder, Treatment-Resistant major depressive disorder obsessive-compulsive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DEPRESSION BIPOLAR DISORDER MAJOR DEPRESSION MAJOR DEPRESSIVE DISORDER MAJOR DEPRESSIVE EPISODE OBSESSIVE-COMPULSIVE DISORDER TREATMENT RESISTANT DEPRESSION

Contacts and locations

Locations

University of Iowa Health Care
RECRUITING

Iowa City, Iowa, 52242, United States

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