Can brain scans and voice recordings predict the best depression treatment?
NCT ID NCT04480918
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is a registry that will follow up to 1,000 adults with treatment-resistant depression or obsessive-compulsive disorder (OCD) who receive electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), or ketamine/esketamine. Researchers will collect data from brain scans, cognitive tests, voice recordings, and genetic tests before, during, and after treatment. The goal is to find biological markers that can predict which therapy works best for each person, moving toward personalized psychiatry.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Iowa Health Care
RECRUITINGIowa City, Iowa, 52242, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), ketamine, esketamine
What this could lead to
If successful, this could help doctors choose the best treatment for each patient with depression or OCD, making care more personalized.
What could go wrong
This is an observational registry, not a controlled trial, so it cannot prove which treatment works best. Results may take years and might not change practice directly.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.