SUBSTANCE USE DISORDER (SUD)

This study is testing a new mutual-help group called the TLC Program for transgender adults who use substances or are recently in recovery. The program uses mindfulness and values-based skills from Acceptance and Commitment Therapy (ACT) to improve mental health and reduce substa…

This pilot study looks at two ways to help pregnant and postpartum people with substance use disorder stay in treatment. The first is a standard check for social needs like housing or childcare, with referrals to community help. The second offers small rewards for recovery-suppor…

This pilot study tests two digital programs designed to help people recently released from prison avoid returning to substance use. The study will enroll 20 adults living in community correctional centers who have a history of substance problems. Researchers will track how often …

This study tests a program to help people with HIV and substance use stick to their HIV medications and stay engaged in care. The program focuses on coping skills, managing substance use, and improving HIV care habits. About 50 adults with HIV who have used substances like cannab…

This study tests whether a group therapy for PTSD, adapted for prisons, can help people reduce drug use, mental health issues, and crime after they leave prison. About 640 incarcerated adults across 10 US prisons will either receive the group therapy or a self-help workbook. Rese…

This study tests whether personalized deep brain stimulation (DBS) is safe and can reduce cravings and opioid use in people with severe, treatment-resistant opioid use disorder. Six adults aged 22-75 who have used opioids for over 5 years and have not responded to other treatment…

This study tests a smartphone-based reward program to help 36 veteran smokers quit before major elective surgery. Participants earn rewards for verified smoke-free days. The goal is to see if this approach is practical and helps reduce surgical risks.

This study tests whether a long-acting injectable HIV prevention medication (cabotegravir) is practical and effective for adults who inject drugs. One hundred participants will receive the shot along with support services. The goal is to see if people stick with the treatment and…

This study tests a program called MEPS that uses a mobile app, peer mentors, and incentives to help people recently released from jail access HIV prevention (like PrEP), STI testing, and substance use treatment. About 300 people across three California counties will take part. Th…

This study is creating and testing short videos for teens (ages 12-17) and their parents after a serious injury that requires a hospital stay. The goal is to prevent post-traumatic stress disorder (PTSD) and substance use. The videos will be developed with input from families and…

This study looks at three different ways to manage pain after childbirth in mothers who are being treated for opioid use disorder. Researchers want to see which method works best for pain relief and whether it also helps reduce anxiety, depression, and improve overall well-being.…

This study tests whether music therapy can help people with substance use disorder reduce their addiction and improve their lives. 600 adults from several European countries will either join active music groups, listen to music, or receive standard treatment. Researchers will mea…

This study tests whether a gentle brain stimulation technique called tDCS can help people with cocaine addiction feel less craving. 120 adults will receive the stimulation while doing thinking tasks, and researchers will use brain scans to see how it works. The goal is to develop…

This study tests whether an 8-week person-centered occupational therapy program can improve daily activities, self-belief, and mental strength in people recovering from substance use disorder. About 34 adults who have completed detox will be split into therapy and control groups.…

This early-stage study at Yale tests whether a single 25mg dose of psilocybin is safe and tolerable for people whose daily life is affected by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug and be followed for up to 6 weeks, with optional l…

This study aims to adapt and test a digital version of the World Health Organization's mental health guide for substance use disorders in primary care settings in Pakistan. Researchers will train 300 primary care doctors in three major cities and measure how feasible and acceptab…

This study aims to develop a new tool to measure the consequences of substance use, helping researchers better understand treatment outcomes. Researchers will interview 50 people, including patients, caregivers, and clinicians, to identify key themes and create survey questions. …

This study looks at whether having peer support workers—people who have personally used drugs—in the emergency department can make patients who use drugs feel more comfortable and less likely to leave before their treatment is done. About 3,181 adults visiting the ER at Vancouver…

This study looks at two different approaches to help pregnant and postpartum people with anxiety, depression, or substance use. About 1 in 5 new mothers face these issues. The study will involve 1,270 participants across 32 U.S. clinics. Half the clinics will use a standard healt…

This study looks at how quitting smoking for six weeks affects the body's chemistry and gut bacteria in people with substance use disorders. Researchers will compare a smoking cessation program to usual care in 100 adults, measuring changes in cravings, mood, and biological marke…

This study tests whether a short program with a nurse case manager helps people leaving prison attend more regular doctor visits instead of going to the emergency room. About 488 adults with substance use history and chronic health conditions will be split into two groups: one ge…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve how accurately adults in Hong Kong remember and report past mental health problems. Researchers will compare the standard interview method with the cale…

This study is testing whether a smartphone app can help young people aged 14 to 35 with alcohol or cocaine use disorder by training their brain to say "no" to substance-related cues. Participants will use the app for short training sessions over a month, plus booster sessions. Th…