Brain pacemaker aims to curb opioid cravings

NCT ID NCT07214467

Recruiting now Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This early study tests whether personalized deep brain stimulation (DBS) can safely reduce cravings and opioid use in 6 adults with severe, treatment-resistant opioid use disorder. Researchers will first map brain activity to find each person's craving signals, then deliver targeted stimulation. The main goal is safety, with a preliminary look at whether it helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Deep brain stimulation (DBS) device
What this could lead to: If it works, this could point toward a new brain-based treatment for people with severe opioid addiction who haven't improved with other therapies.
What could go wrong: This is a very early, tiny study (only 6 people) focused on safety first. It may not reduce opioid use, and brain surgery carries risks like infection or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Behavior, Addictive opiate dependence substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID USE DISORDER (OUD) SUBSTANCE USE DISORDER (SUD)

Contacts and locations

Locations

University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States

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