SUBSTANCE USE DISORDER (SUD)

This study tests a new program to help people with HIV who also use substances stick to their HIV medications and stay in care. The program teaches coping skills and ways to manage substance use. Researchers want to see if the program is practical and acceptable to participants. …

This study tests two digital treatment programs for people recently released from prison who have a history of substance use problems. The goal is to see if these programs are practical and helpful in preventing relapse and return to prison. About 20 participants will use the pro…

This study tests a mobile program that gives veterans small rewards for staying smoke-free before and after major elective surgery. Smoking raises the risk of problems like infections and longer hospital stays after surgery. The program uses a smartphone app to check if participa…

This study looks at two ways to help pregnant and postpartum people with substance use disorder stay in treatment. One approach screens for social needs like housing or childcare and connects patients to community help. The other offers small rewards for recovery-supportive behav…

This pilot study tests a personalized deep brain stimulation (DBS) method for people with severe, treatment-resistant substance use disorders. Ten participants will first undergo detox, then have temporary electrodes placed in their brains to map addiction-related circuits, follo…

This study tests whether personalized deep brain stimulation (DBS) can safely reduce cravings and opioid use in people with severe, treatment-resistant opioid use disorder. Six adults aged 22-75 who have used opioids for over 5 years and have not responded to other treatments wil…

This study tests whether a group therapy for PTSD, adapted for prisons, can help people reduce drug use and avoid crime after they are released. About 640 adults in prisons across several states will either receive the group therapy or a self-help workbook. Researchers will also …

This study tests a mutual-help group called the TLC Program for transgender adults who struggle with substance use or are recently in recovery. The program uses mindfulness and values-based skills from Acceptance and Commitment Therapy (ACT) to improve mental health and reduce HI…

This study tests a digital program called WORTH Paths for women aged 18-44 who have been involved in the criminal justice system, have a substance use disorder, and need birth control. The program includes three virtual group sessions and digital activities to help reduce drug us…

This study is testing a long-acting injectable HIV prevention medication (cabotegravir) in 100 adults who inject non-prescription drugs and are at risk for HIV. Participants receive the shot along with support services. The goal is to see if people stick with this prevention meth…

This study is creating and testing short videos for teens (ages 12-17) and their parents after a traumatic injury that requires a hospital stay. The goal is to prevent posttraumatic stress disorder (PTSD) and substance use. The videos will be developed with input from families an…

This study tests whether a program called MEPS can help people recently released from jail access HIV prevention, PrEP, and substance use treatment. The program includes a mobile app, peer mentors, and service incentives. About 300 people who were assigned male at birth, aged 18-…

This study tests whether a gentle brain stimulation technique called tDCS can lower cravings in people with cocaine addiction. About 120 adults will receive the stimulation while doing thinking tasks, and brain scans will track changes. The goal is to see if this approach can hel…

This study tests a smartphone app designed to help teenagers and young adults with alcohol or cocaine use disorder improve their self-control around substance-related cues. Researchers will recruit 210 participants aged 14 to 35 from treatment centers. Half will use an app with s…

This study tests whether an 8-week personalized occupational therapy program can help people with substance use disorder perform daily activities better, feel more confident, and bounce back from stress. About 34 adults who have completed detox will be split into a therapy group …

This study looks at three different ways to manage pain after childbirth in women who are on medication for opioid use disorder. The goal is to find which method works best for pain control and whether it also helps reduce anxiety, depression, and improve overall well-being. Abou…

This study tests whether music therapy can help people with substance use disorder reduce their addiction severity and improve their recovery. 600 adults from several European countries will be randomly assigned to active music-making, music listening, or standard treatment. The …

This early-stage study at Yale University is testing whether a single 25mg dose of psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for 50 adults whose daily life is affected by mood, anxiety, trauma, or addiction symptoms. Participants do not need a fo…

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study tests whether using a life history calendar—a simple grid that helps people remember important life events—can improve how accurately adults in Hong Kong recall and report mental health conditions like depression, anxiety, and PTSD. Researchers will compare the standar…

This study looks at how Ohio START, a program that connects parents with treatment and peer mentors, helps rural families reduce substance use and improve children's health. About 400 parents will answer surveys and share details about their daily routines and social connections …

This study looks at whether having peer support workers—people who have personally used drugs—in the emergency department can make patients more comfortable and reduce the number who leave before their care is complete. About 3,181 adult ER patients who use substances will be inc…

This study looks at two different approaches to help pregnant and postpartum people get better mental health care. One approach focuses on improving care within doctor's offices, while the other partners with community groups. About 1,270 participants across 32 U.S. clinics will …

This study aims to see if a digital version of the WHO's mental health guide for substance use disorders can be used effectively in primary care settings in Pakistan. Researchers will train 300 primary care doctors in three major cities using this digital tool. The goal is to und…

This study looks at how analyzing the weekly written stories of people in rehab for substance use can help track their emotional and mental changes. About 35 men in a residential treatment center in Mexico will write about their feelings and challenges, and fill out questionnaire…

This study aims to develop a new tool to measure outcomes in substance use disorder treatment. Researchers will interview patients, caregivers, and clinicians to identify key themes and create a questionnaire. The goal is to provide a more accurate way to assess treatment effecti…

This study looks at whether a short program with a nurse case manager can help people leaving prison get medical care instead of going to the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra help f…