SUBSTANCE USE DISORDER (SUD)

This study looks at whether adding a clinical pharmacist to community mental health teams (called FACT teams) can help people with severe mental illness and substance use disorders feel better and manage their medications more effectively. About 160 adults will take part, and the…

This study looks at whether offering medication and therapy for substance use disorders can help homeless veterans stay in their homes. About 8,000 veterans in VA supportive housing will be offered addiction treatment. The goal is to reduce returns to homelessness by making treat…

This study tests a program called TBI-RECOVER that screens for brain injury and provides special support in substance use treatment. About 900 adults in outpatient therapy will take part. The goal is to see if the program helps people stay in treatment longer and feel better.

This study tests if adding a safe dye to a drink can prove that urine samples are real and not tampered with. About 114 adults with substance use disorder will drink Gatorade with or without the dye, then provide a urine sample 15 minutes later. Researchers will check for the dye…

This study will test two new services at a large Chicago health center: routine substance use screening for all patients, and a program that asks people to refer friends or partners who might need HIV or addiction care. The goal is to see if these methods help more people learn t…

This study tests if a special job training program helps people with substance use disorder recover better. About 50 adults in West Virginia who are in a day report program will either get the job training or standard help. Researchers will check if the training improves their re…

This study looks at whether a short follow-up session can help people who inject drugs stay engaged with healthcare after finishing hepatitis C treatment. Researchers will also study how discrimination affects treatment and support between injecting partners. About 50 adults and …

This study looks at how a short therapy called Written Exposure Therapy (WET) works for people with both PTSD and substance use disorder who are in residential treatment. About 108 participants will either do WET or neutral writing alongside their usual care. Researchers will mea…

This study looks at how to best engage family members when their loved one starts treatment for a substance use disorder. Researchers will test different strategies to see which ones help family members join a support program called CRAFT. About 100 family members and their loved…

This study will test a psychoeducation program based on cognitive behavioral therapy for 44 adults with substance use disorder. The program aims to reduce feelings of social exclusion and hopelessness, and improve skills to prevent relapse. Participants will attend sessions and c…

This study aims to learn why people's mood, behavior, and brain responses differ when using recreational drugs like cannabis. Researchers will use brain scans and questionnaires to measure reward processing and substance use patterns in 144 healthy young adults aged 18-21. The go…

This study looks at how communities can better use deflection programs—which guide people with substance use toward treatment instead of arrest. Researchers will test two community engagement strategies across 20 communities in five states. The goal is to see which approach impro…

This study will test a workshop program for 45 adults in prison who have both ADHD and substance use disorder. The program combines medical care, team coordination, and support to improve their health and well-being. Researchers will measure how acceptable the program is and whet…

This study tests a program called ADD'Pro that combines addiction care with job counseling to help people with substance use disorders find competitive employment. About 100 adults will be randomly assigned to either the ADD'Pro program or standard employment services. The main g…

This study aims to understand how people recover from substance use disorders by observing their behavior, thoughts, and social interactions in therapeutic communities in Mexico. Researchers will follow 60 adults for 8 to 12 weeks, using surveys and daily check-ins to track cravi…