SUBSTANCE USE DISORDER (SUD)

This study tests whether a program called CourtConnect, where peer recovery specialists meet with people in courthouses, can increase substance use disorder treatment and reduce overdose and incarceration. The program provides information, referrals, and up to three months of fol…

This study tests a new eight-session group therapy program for adults hospitalized with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and behavioral activation to help participants manage cravings and develop alternati…

This study tests whether a gentle electrical stimulation of a nerve in the ear (called taVNS) can help people who are dependent on the drug tiletamine. Thirty participants will receive either real or sham stimulation over five days. Researchers will measure changes in cravings, m…

This study tests whether a new four-session group program, called the First Step Program, can be delivered in hospital settings and help people with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and group support to bo…

This study will bring medication for addiction and cognitive behavioral therapy to homeless veterans living in VA supportive housing. The goal is to help them stay housed and reduce substance use. About 8,000 veterans across multiple VA sites will take part.

This study tests if adding a safe dye to a drink can prove that urine samples are real and not tampered with. About 114 adults with substance use disorder will drink Gatorade with or without the dye, then provide a urine sample 15 minutes later. Researchers will check for the dye…

This study tests a new 8-session group program designed to help people with substance use disorder better understand and regulate their emotions. About 20 adults receiving inpatient care at two hospitals in Korea will take part. The program combines motivational interviewing and …

This study will test a psychoeducation program based on cognitive behavioral therapy (CBT) for 44 adults diagnosed with substance use disorder. The program aims to reduce feelings of social exclusion and hopelessness, and improve participants' ability to cope with relapse. Resear…

This pilot study tests a one-time 'booster' session for people who inject drugs and their injecting partners, given right after finishing hepatitis C treatment. The session helps them set health goals, identify barriers, and improve communication to stay engaged in ongoing health…

This study looks at whether adding a clinical pharmacist to community mental health teams (called FACT teams) helps people with severe mental illness and substance use disorders feel better and manage their medications more effectively. About 160 adults will take part, and the st…

This study tests different strategies to get family members more involved when a loved one starts treatment for substance use disorder. Researchers will ask 100 family members to try and rank various engagement methods online. The goal is to find which approaches work best to hel…

This study will observe 60 adults in residential therapeutic communities in Mexico to understand how recovery from substance use unfolds over time. Participants will answer quick mobile surveys several times a day about cravings, mood, and social interactions for 8 to 12 weeks. T…

This study will test two new services at a large Chicago health center: routine substance use screening for all patients, and a program that asks people to refer friends or partners who might need HIV or addiction care. The goal is to find more people with undiagnosed HIV or subs…

This study looks at how communities can better use deflection programs—which guide people with substance use toward treatment instead of arrest. Researchers will test two community engagement strategies across 20 communities in five states. The goal is to see which approach impro…

This study tests a program called ADD'Pro that combines addiction treatment with personalized job counseling to help people with substance use disorders return to work. About 100 adults will be randomly assigned to either the ADD'Pro program or standard employment services. Resea…

This study looks at how a brief writing therapy called Written Exposure Therapy (WET) works for people with both PTSD and substance use disorders who are in residential treatment. About 108 participants will either do WET or neutral writing alongside their usual care. Researchers…

This study tests if a special job training program helps people with substance use disorder recover better. About 50 adults in West Virginia who are in a day report program will either get the job training or standard help. Researchers will check if the training improves their re…

This early-phase study will give 144 healthy young adults (ages 18-21) a single dose of THC (7.5 mg) or a placebo in a capsule, then use brain scans and behavioral tasks to measure how THC affects mood, reward processing, and learning. The goal is to understand why some people re…