SUBSTANCE USE DISORDER (SUD)

This pilot study looks at two strategies to help pregnant and postpartum people with substance use disorder stay in treatment. One strategy screens for social needs like housing or childcare and connects patients to support. The other offers rewards for recovery-supportive behavi…

This study tests a digital group program called WORTH Paths for women aged 18-44 who have been involved in the criminal legal system, have a substance use disorder, and need contraception but aren't using it. The program includes three virtual group sessions with interactive acti…

This pilot study tests a personalized deep brain stimulation (DBS) method for people with severe, treatment-resistant substance use disorders. Ten participants will first undergo detox, then have temporary electrodes placed in their brains to map addiction-related circuits, follo…

This study tests a mutual-help group called the TLC Program for transgender adults who struggle with substance use or are recently in recovery. The program uses mindfulness and values-based skills from Acceptance and Commitment Therapy to improve mental health and reduce HIV risk…

This study tests two digital treatment programs for people recently released from prison who have a history of substance use problems. The goal is to see if these programs are practical and helpful in preventing relapse and return to prison. About 20 participants will use the dig…

This study tests a smartphone app designed to strengthen self-control in teens and young adults (ages 14-35) being treated for alcohol or cocaine use disorder. Participants will complete 12 short training sessions over about a month, plus booster sessions. The goal is to see if t…

This study tests a new program to help people with HIV who also use substances stick to their HIV medications and stay in care. The program teaches coping skills and ways to manage substance use. Researchers want to see if the program is practical and acceptable to participants. …

This study tests whether a trauma-focused group therapy (CPT-CJ) given in prison can reduce drug use, PTSD symptoms, and re-arrest after release. 640 incarcerated adults from about 10 prisons will either receive the group therapy or a self-help workbook. Researchers will also mea…

This early study tests whether personalized deep brain stimulation (DBS) can safely reduce cravings and opioid use in 6 adults with severe, treatment-resistant opioid use disorder. Researchers will first map brain activity to find each person's craving signals, then deliver targe…

This study tests a mobile app and financial rewards to help veterans quit smoking before major elective surgery. Smoking increases the risk of complications after surgery, but quitting can be hard. The program uses a carbon monoxide monitor and app to verify abstinence, with ince…

This study is creating and testing short videos for teens (ages 12-17) and their parents after a traumatic injury that requires a hospital stay. The goal is to prevent posttraumatic stress disorder (PTSD) and substance use. The videos will be developed with input from families an…

This study tests a program called Mobile Enhanced Prevention Support (MEPS) for people recently released from jail or prison who have substance use disorders. The program pairs participants with a peer mentor, offers cash incentives for using health services, and provides a smart…

This study is testing whether a long-acting injectable HIV prevention drug, called cabotegravir, can work for people who inject drugs. The trial will enroll 100 adults who have injected non-prescription drugs in the past 6 months and are at risk for HIV through sexual contact. Pa…

This study is testing whether music therapy can help people with substance use disorder. 600 participants across Europe will be randomly assigned to either active music-making, music listening, or standard treatment. The goal is to see if music therapy improves addiction severity…

This early-stage study at Yale is testing whether a single 25 mg dose of psilocybin is safe and tolerable for people whose daily life is impaired by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug openly (everyone knows they get it) and be f…

This study tests whether a gentle brain stimulation technique (tDCS) combined with cognitive training can reduce cravings in people with cocaine addiction. 120 participants will receive either real or sham stimulation for 20 minutes a day, three times a week, for five weeks. Rese…

This study tests whether an 8-week personalized occupational therapy program can help people with substance use disorder perform daily activities better, feel more confident, and bounce back from stress. About 34 adults who have completed detox will be split into a therapy group …

This study tests whether peer support workers—people with lived experience of substance use—can help people who use drugs feel safer and stay in the emergency department until their care is complete. The study will compare what happens when peer workers are on shift versus when t…

This study looks at three different ways to manage pain after childbirth in women who are on medication for opioid use disorder. The goal is to find which method works best for pain control and whether it also helps reduce anxiety, depression, and improve overall well-being. Abou…

This study follows 35 men in residential rehab for severe substance use. They write weekly stories about their feelings and challenges, and fill out questionnaires every two weeks. Researchers use natural language processing to analyze the stories and look for patterns that might…

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study follows 400 parents in rural Ohio who are part of the Ohio START program, which connects them to substance use treatment and peer mentors. Researchers want to see if having treatment services close to home and strong social support helps parents recover and improves th…

This study aims to see if a digital version of the WHO's mental health guide for substance use disorders can be used effectively in primary care settings in Pakistan. Researchers will train 300 primary care doctors in three major cities using this digital tool. The goal is to und…

This study looks at two different approaches to help pregnant and postpartum people get better mental health care. One approach focuses on improving care within doctor's offices, while the other partners with community groups. About 1,270 participants across 32 U.S. clinics will …

This study aims to develop a new tool to measure outcomes in substance use disorder treatment. Researchers will interview patients, caregivers, and clinicians to identify key themes and create a questionnaire. The goal is to provide a more accurate way to assess treatment effecti…

This study looks at whether a program with a nurse case manager can help people leaving prison visit a doctor or clinic instead of the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra support from …

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve the accuracy of mental health surveys. Researchers in Hong Kong will ask 2,500 adults about their mental health using either a standard interview or one…