SUBSTANCE USE DISORDER (SUD)

This study tests whether a group therapy for PTSD, adapted for prisons, can help people reduce drug use, mental health issues, and crime after they leave prison. About 640 incarcerated adults across 10 US prisons will either receive the group therapy or a self-help workbook. Rese…

This study tests a smartphone-based reward program to help 36 veteran smokers quit before major elective surgery. Participants earn rewards for verified smoke-free days. The goal is to see if this approach is practical and helps reduce surgical risks.

This study tests whether music therapy can help people with substance use disorder reduce their addiction severity and improve their recovery. 600 adults from several European countries will be randomly assigned to active music-making, music listening, or standard treatment. The …

This study tests a new mutual-help group called the TLC Program for transgender adults who struggle with substance use or are recently in recovery. The program uses mindfulness and values-based skills from Acceptance and Commitment Therapy (ACT) to improve mental health and reduc…

This study tests whether personalized deep brain stimulation (DBS) is safe and can reduce cravings and opioid use in people with severe, treatment-resistant opioid use disorder. Six adults aged 22–75 who have used opioids for over 5 years will undergo brain mapping to identify cr…

This pilot study tests whether a program that teaches coping skills and supports HIV care engagement is practical and helpful for people living with HIV who also use substances. The study will enroll 50 adults and measure satisfaction, retention, and medication adherence. The goa…

This study looks at two ways to help pregnant and postpartum people with substance use disorder stay in treatment. One approach screens for social needs like housing or childcare and connects them to community help. The other offers small rewards for positive recovery actions. Th…

This study tests two digital treatment programs for substance use in 20 adults recently released from Canadian prisons. Participants use the programs for 6 months, and researchers track how often they complete modules, whether they relapse, and if they return to prison. The goal …

This study tests a program called MEPS that uses a mobile app, peer mentors, and incentives to help people recently released from jail access HIV prevention (like PrEP), STI testing, and substance use treatment. About 300 people across three California counties will take part. Th…

This study is testing short videos to help teens and their parents cope after a traumatic injury. The goal is to prevent posttraumatic stress disorder (PTSD) and substance use. About 92 teens aged 12-17 and their parents will take part. They will watch the videos and complete sur…

This study tests a long-acting injectable HIV prevention medication (cabotegravir) in 100 adults who inject non-prescription drugs and are at risk for HIV. Participants receive the shot plus support services. The goal is to see if people stick with the treatment over 7 months.

This study looks at three different ways to manage pain after childbirth in mothers who are being treated for opioid use disorder. The goal is to find which method works best for pain relief and may also help reduce anxiety, depression, and improve overall well-being. About 20 wo…

This study tests whether a gentle brain stimulation technique called tDCS can help people with cocaine addiction feel less craving. 120 adults will receive the stimulation while doing thinking tasks, and researchers will use brain scans to see how it works. The goal is to develop…

This study tests whether an 8-week person-centered occupational therapy program can improve daily activities, self-belief, and mental strength in people recovering from substance use disorder. About 34 adults who have completed detox will be split into therapy and control groups.…

This early-stage study at Yale tests whether a single 25mg dose of psilocybin is safe and tolerable for people whose daily life is affected by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug and be followed for up to 6 weeks, with optional l…

This study looks at two different approaches to help pregnant and postpartum people with anxiety, depression, or substance use. About 1 in 5 new mothers face these issues. The study will involve 1,270 participants across 32 U.S. clinics. Half the clinics will use a standard healt…

This study aims to develop a new questionnaire to measure the real-world consequences of substance use disorder. Researchers will interview 50 people, including patients, their loved ones, and healthcare providers, to identify the most important outcomes. The goal is to create a …

This study aims to see if a digital version of the WHO's mental health guide for substance use disorders can be used effectively in primary care clinics in Pakistan. Researchers will train 300 doctors in three cities using a smartphone app and then check if the training is practi…

This study looks at how quitting smoking for six weeks affects the body's chemistry and gut bacteria in people with substance use disorders. Researchers will compare a smoking cessation program to usual care in 100 adults, measuring changes in cravings, mood, and biological marke…

This study tests whether a short program with a nurse case manager helps people leaving prison attend more regular doctor visits instead of going to the emergency room. About 488 adults with substance use history and chronic health conditions will be split into two groups: one ge…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve how accurately adults in Hong Kong remember and report past mental health problems. Researchers will compare the standard interview method with the cale…

This study is testing whether a smartphone app can help young people aged 14 to 35 with alcohol or cocaine use disorder by training their brain to say "no" to substance-related cues. Participants will use the app for short training sessions over a month, plus booster sessions. Th…

This study looks at whether having peer support workers—people who have personally used drugs—in the emergency department can make patients more comfortable and reduce the number who leave before their care is complete. About 3,181 adults who visit the ER and use substances can t…