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Sound waves against addiction: helmet zaps brain to curb substance use

NCT ID NCT07684976

Recruiting now Disease control Sponsor: Sunnybrook Health Sciences Centre Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This trial tests whether a helmet that delivers focused ultrasound waves can safely change brain activity in people with moderate-to-severe substance use disorder who haven't responded to medication. Participants receive two MRI-guided sessions targeting brain regions linked to addiction. The study aims to see if this approach reduces substance use and is safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Next Generation Dome Helmet (NGDH) — a device that delivers low-intensity focused ultrasound to specific brain areas
What this could lead to
If successful, this could offer a non-invasive, drug-free way to reduce substance use severity in people with treatment-resistant addiction.
What could go wrong
This is an early feasibility study with only 20 participants, so results may not apply broadly. The treatment may not reduce substance use, and risks from brain ultrasound are still being assessed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SUBSTANCE USE DISORDER (SUD)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Sunnybrook Health Sciences Centre

    RECRUITING

    Toronto, Ontario, M4N 3M5, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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