OCD

This study tests a new, non-invasive brain stimulation method for people with OCD. The treatment uses gentle electrical currents guided by brain wave recordings to target a key brain region. The goal is to reduce OCD symptoms quickly (within five days) and keep them lower for up …

This study tests whether delivering cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 participants will be randomly assigned to one of three delivery methods. The goal is to find ways to make…

This study tests whether a mild nerve stimulation device (tVNS) can make exposure therapy work better for people with OCD. Researchers will enroll 56 adults with moderate to severe OCD. The goal is to see if adding tVNS to standard therapy improves symptoms and is well-tolerated.

This study tests a new 5-day accelerated version of TMS, a brain stimulation treatment already approved for depression and OCD. Researchers want to see if this faster approach can quickly improve symptoms and use brain scans to predict who benefits most. 500 adults with depressio…

This early-stage study at Yale tests whether a single 25mg dose of psilocybin is safe and tolerable for people whose daily life is affected by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug and be followed for up to 6 weeks, with optional l…

This study looks at how natural hormone changes during the menstrual cycle might influence how well a type of therapy called exposure and response prevention (EX/RP) works for women with OCD. Researchers will use brain scans to see how hormones affect brain areas involved in fear…

This study aims to find brain activity and thinking patterns that can predict which people with obsessive-compulsive disorder (OCD) will not respond well to standard treatments. Researchers will use brain scans and cognitive tests to compare 100 participants with OCD to healthy c…

This study will analyze existing medical records from about 12,000 people treated for depression, OCD, or anxiety at Greenbrook clinics. Researchers want to compare how well two treatments—NeuroStar TMS and esketamine—reduce symptoms like low mood. No new treatments are given; th…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs change brain processing. Researchers use brain scans, computer tasks, and interviews to measure shifts in learning, perception, and electrical activity. The goal is to predict…

This study aims to find clear brain and movement markers that can tell apart tics (common in Tourette syndrome) from compulsions (common in OCD). Researchers will use EEG brain scans and smartwatch motion sensors to record 50 patients—25 with OCD and 25 with Tourette—both in the …

This study tests whether a single session of brain stimulation (rTMS) combined with emotion regulation skills training can help people with mood, anxiety, or related disorders better control their emotions. 240 adults aged 18-55 with high emotional distress will be randomly assig…