Diabetes risk from statins in schizophrenia: could metformin be the answer?

NCT ID NCT07045142

Recruiting now Disease control Sponsor: Central South University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 04, 2026 · Updated 5 times

Summary

This study tests whether the diabetes drug metformin can prevent blood sugar increases caused by statins in people with schizophrenia. Researchers will give 400 patients either metformin or a placebo alongside atorvastatin for six months. The goal is to see if metformin helps keep glucose levels stable, reducing the risk of diabetes and heart disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Metformin
What this could lead to: If it works, this could offer a way to prevent diabetes in schizophrenia patients who need statins for heart health, improving their overall care.
What could go wrong: This is a phase 3 trial, but it's still early to know if metformin will work for this specific use. The study focuses on blood sugar markers, not long-term health outcomes, and metformin may cause digestive side effects.

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Conditions

The condition(s) this trial relates to.

Dyslipidemias inherited lipid metabolism disorder schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOPHRENIA

Contacts and locations

Locations

Junshan District Psychiatric Rehabilitation Hospital
ACTIVE_NOT_RECRUITING

Yueyang, Hunan, 414000, China
Mental Health Institute of Second Xiangya Hospital, CSU
RECRUITING

Changsha, Hunan, China
The Second People's Hospital of Dali Bai Autonomous Prefecture
COMPLETED

Dali, Yunnan, China
The Second People's Hospital of Xiangyin County
ACTIVE_NOT_RECRUITING

Yueyang, Hunan, 410500, China
The Third Hospital of Changsha County
ACTIVE_NOT_RECRUITING

Changsha, Hunan, China
Xiangshan County Traditional Chinese Medicine Hospital Medical and Health Group Three Hospitals District
ACTIVE_NOT_RECRUITING

Xiangshan, Zhejiang, 315799, China
Yueyang Rehabilitation Hospital
RECRUITING

Yueyang, Hunan, 414022, China
Zhumadian Second People's Hospital
ACTIVE_NOT_RECRUITING

Zhumadian, Henan, China

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