Magic mushroom compound could lift Veterans' depression

NCT ID NCT07226232

Recruiting now Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help veterans with depression that hasn't improved with at least two other treatments. 240 veterans will receive either psilocybin or a placebo in a controlled setting. The goal is to see if it reduces depression symptoms and to track any side effects.

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSION

Contacts and locations

Locations

Birmingham VA Medical Center, Birmingham, AL
RECRUITING

Birmingham, Alabama, 35233-1927, United States
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
RECRUITING

Philadelphia, Pennsylvania, 19104-4551, United States
Tuscaloosa VA Medical Center, Tuscaloosa, AL
RECRUITING

Tuscaloosa, Alabama, 35404-5015, United States
VA Portland Health Care System, Portland, OR
RECRUITING

Portland, Oregon, 97207-2964, United States
VA Puget Sound Health Care System Seattle Division, Seattle, WA
RECRUITING

Seattle, Washington, 98108-1532, United States

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