Mental disorder

This 12-week study is for people who completed a previous trial of the ketogenic diet for first-episode bipolar disorder. Researchers want to see if the diet can improve symptoms like depression, mania, and psychosis, as well as brain energy metabolism and insulin resistance. Abo…

This study is testing the long-term safety of a daily pill called OLZ/SAM (olanzapine plus samidorphan) in 236 teenagers with schizophrenia or bipolar I disorder. Participants have already completed a previous study with the same drug. The goal is to see if the drug is safe and t…

This early-stage trial evaluates an experimental oral drug called VV119, which is being developed for schizophrenia. The study enrolls healthy volunteers to receive a single dose of VV119 or a placebo, with some participants taking it with food to see if meals affect how the drug…

This study tests whether a daily probiotic supplement can improve the balance of gut bacteria in children aged 3 to 7 who have autism and digestive issues like constipation or stomach pain. Over 6 months, 60 children will receive either the probiotic or a placebo. The main goal i…

This study offers open/aftercare treatment to adults with obsessive-compulsive disorder (OCD) who have completed an earlier study at Stanford's Rodriguez Lab. Participants receive evidence-based psychotherapy and/or pharmacotherapy from trained professionals. The goal is to see i…

This phase 2 trial is investigating whether psilocybin, the active compound in magic mushrooms, combined with psychological support, is safe and suitable for military veterans and first responders who have both alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD). …

This trial explores whether adding vitamin D and iron supplements to usual OCD treatment can improve the ability to control impulses. It involves 60 people with OCD who will receive the supplements for 12 weeks. Researchers will use brain scans and behavioral tasks to see if thes…

This program provides access to esmethadone (REL-1017), an experimental drug, for people with serious depression who have not responded to standard treatments and cannot join other clinical trials. The goal is to offer a potential treatment option when no satisfactory alternative…

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive either behavioral activation teletherapy plus a non-SSRI antidepressant, or the antidepressant plus teletherap…

This trial investigates whether a long-acting liquid stimulant medication (Quillivant XR) can safely and effectively reduce ADHD symptoms in children with Down syndrome, who are at higher risk for ADHD but often go untreated. The study will compare the medication against a placeb…

This study tests whether polyphenols from muscadine wine, served as a non-alcoholic beverage, can improve cognitive performance, memory, mood, and anxiety in healthy adults over 50. Participants will drink either the polyphenol-rich beverage or a placebo and complete a series of …

This pilot study is testing whether one 25 mg dose of psilocybin, given alongside psychotherapy, can ease depression in people with bipolar II disorder who haven't responded to at least two prior treatments. Using brain scans (fMRI), researchers will look at how the drug affects …

This study looks at the long-term safety and effectiveness of azetukalner in adults with major depressive disorder. Participants must have successfully completed a previous phase 3 study of this drug. The goal is to monitor side effects and track changes in depression symptoms ov…

This trial tests whether a culturally adapted program of case manager support can improve survival, reduce hospital readmissions, and boost quality of life for adults recovering from accidental burn injuries in Pakistan. Participants receive up to eight sessions with a case manag…

This early study tests a mobile health program called WINGS+++ for women who use opioids and have experienced intimate partner violence. The program includes three sessions on a tablet or smartphone with videos, exercises, and a peer navigator to help connect to services. Researc…

This trial tests whether a personalized training program called 'Kleuter Extra' can improve executive functioning—skills like attention, self-control, and planning—in preschoolers aged 4 to 6 who have severe congenital heart disease. Many children with this condition face thinkin…

This trial investigates the long-term safety of ecopipam, a drug that blocks dopamine D1 and D5 receptors, in children, adolescents, and adults with Tourette syndrome. Participants who completed a prior study may enroll and receive ecopipam for up to 24 weeks or longer. The main …

This trial compares two group-based education programs for people with serious mental illness who also have chronic physical conditions like diabetes or heart disease. One program, Integrated Illness Management and Recovery (I-IMR), covers both mental and physical health self-man…

This study tests whether a digital expert team can help people on long-term sick leave with muscle or common mental health issues return to work. Participants fill out a digital questionnaire and have a video meeting with their doctor and a team of specialists who then create a p…

This study looks at whether a combination of ibogaine-magnesium, 5-MeO-DMT, magnetic e-Resonance therapy (MeRT), and physiological supplements can help special operations veterans with PTSD, depression, suicidal thoughts, and cognitive problems from traumatic brain injury. Partic…

This study tests a program called Mastering the World of Work (MWW) designed to help people with serious mental illness improve their job outcomes. The program focuses on building metacognitive skills — the ability to understand one's own thoughts and others' perspectives — throu…

This study tests a group therapy program called Building Spiritual Strength for Veterans experiencing moral injury syndrome—a condition involving deep guilt, shame, or loss of meaning after traumatic events. About 200 Veterans will be randomly assigned to either this spiritually …

This study tests a specially designed psychological treatment module for men in Pakistan who struggle with both depression and substance use disorders. The module combines several therapy approaches and is culturally adapted. Half of the participants receive this 12-session progr…

This study looks at whether online group cognitive behavioural therapy (CBT) for mothers with postpartum depression can improve their baby's ability to regulate emotions. The trial involves 172 mothers and their infants (4-12 months old) in Ontario. Mothers receive either CBT plu…

This study investigates the long-term safety and effectiveness of SPN-812 (viloxazine) in children and adolescents with ADHD. Participants who completed a prior SPN-812 study can continue taking the medication once daily for up to 72 months. The trial includes children aged 4–17 …

This study tests whether a probiotic called Lactobacillus plantarum can improve social interactions, reduce inflammation, and enhance quality of life in adults with autism spectrum disorder. Twelve participants take the probiotic for 8 weeks, with assessments including blood test…

This trial investigates whether drinking a beverage made from 30 different organic vegetables daily for four weeks can improve gut microbiome diversity, reduce inflammation, and ease PTSD symptoms in adults diagnosed with PTSD. Participants are randomly assigned to receive either…

This study tests a program called PIXI that coaches parents of infants diagnosed with rare neurogenetic disorders (such as Fragile X, Angelman, or Down syndrome) during the first year of life. The program combines education about the disorder, guided parent-child interaction acti…

This study tests an online program called SYNC designed to help youth aged 16-20 in foster care manage stress, build coping skills, and feel more comfortable seeking mental health help. Participants take part in an 8-module online curriculum with support from service providers an…

This study tests whether a 12-week mobile program can improve cognitive function and motivation in people aged 15–40 who have had psychosis symptoms for less than five years. Participants will either use the mobile training or continue their usual care, and researchers will compa…

This study tests whether one or two doses of psilocybin, the active ingredient in magic mushrooms, combined with talk therapy, can help people with treatment-resistant depression. Participants are adults aged 18 to 65 whose depression has not improved with standard treatments. Re…

This study tests whether choline, a vitamin-like nutrient, can improve memory, thinking, and behavior in children aged 2.5 to 5 years with Fetal Alcohol Spectrum Disorders (FASD). Participants receive choline daily for either 3 or 6 months. Researchers measure changes in memory, …

This study tests whether personalized smartphone notifications can improve mood, sleep, and physical activity in medical interns. Participants receive mood, activity, or sleep tips through a mobile app, with the content chosen by a learning algorithm. The goal is to see if these …

This study investigates whether combining the medication lovastatin with intensive reading tutoring can improve reading abilities in children and young adults (ages 8-20) with Neurofibromatosis Type 1 (NF1) who have reading disabilities. Participants first receive either lovastat…

This study tests whether a longer, family-involved form of cognitive behavioral therapy (CBT) can work as well as CBT combined with an antidepressant (SSRI) for children and teens with anxiety disorders. Participants aged 7 to 17 with separation, generalized, or social anxiety wi…

This study tests whether a rapid form of brain stimulation, called accelerated intermittent theta-burst stimulation (aiTBS), can relieve depression in people with bipolar II disorder whose depression has not responded to other treatments. Participants receive either real or sham …

This study tests a behavioral program called Individualized Developmental Care (NIDCAP) for newborns with complex congenital heart disease. The program aims to reduce stress from the hospital environment by supporting parent involvement, creating a soothing setting, and adjusting…

This study tests whether a lifestyle physical activity program, supported by a Fitbit and phone counseling, can help women with depression who are in alcohol treatment reduce their risk of relapse. Participants are randomly assigned to either receive the full program or just a Fi…

This study tests whether measurement-based care — where therapists regularly track symptoms using questionnaires — adds extra benefit to weekly psychotherapy for adults with depression or anxiety. Participants are randomly assigned to measurement-based care, standard therapy, or …

This study is testing the long-term safety and effectiveness of a drug called TSND-201 for adults with PTSD. Participants who completed an earlier blinded trial of TSND-201 can receive up to three treatment courses over 48 weeks, each consisting of four weekly doses. The goal is …

This study looks at whether starting a cardiac rehabilitation programme soon after leaving the hospital helps people with coronary artery disease live longer and avoid hospital stays for heart problems. The programme includes counseling, education, and exercise sessions three tim…

This study tests whether offering PTSD therapy to people in jail who also have opioid or stimulant use disorder can help them start addiction treatment after release. Researchers will screen and refer participants, then randomly assign some to start therapy immediately in jail an…

This phase 2 trial tests whether lamivudine, an antiviral drug, can improve symptoms in people with Rett syndrome, a rare genetic disorder that affects movement, communication, and behavior. Ten participants will take the drug by mouth for a set period, and researchers will measu…

This study planned to test the drug bumetanide in children aged 5 to 17 with autism of known cause. The goal was to see if it could improve autism symptoms. However, the trial was withdrawn before enrolling any participants, so no new information was gathered.

This study tests a personalized deep brain stimulation (DBS) approach for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Ten adults will first undergo brain mapping to find the best stimulation targets, then receive a DBS dev…

This study tests a nurse-led program that uses home monitoring devices to help older adults with conditions like heart failure, diabetes, and depression manage their health after leaving the hospital. The goal is to improve care coordination and reduce hospital readmissions. Abou…

This study tests a program called REAL Fathers in Uganda, where respected community men mentor young fathers (ages 16-25) on positive parenting, conflict resolution, and family planning. Over 4,700 participants are involved. The goal is to see if this approach reduces intimate pa…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study follows about 1,756 adults who were part of a larger trial and received either ketamine or etomidate during emergency intubation. Researchers want to see if ketamine can reduce PTSD symptoms one year later, since it may block the brain's formation of traumatic memories…

This study looks at whether adding topiramate (a seizure medication) to clozapine can help with weight loss and improve symptoms in people with treatment-resistant schizophrenia or schizoaffective disorder. About 50 overweight or obese adults aged 17-59 who are already on clozapi…

This early-phase trial tests a single injection of AAV-MECP2 gene therapy into the spinal fluid of 8 girls aged 4-10 with Rett syndrome, a severe neurodevelopmental disorder. The goal is to see if the treatment is safe and can reduce disease severity. The study is not yet recruit…

This study compares a new blended therapy (online sessions plus in-person visits) to standard in-person therapy for teens with conduct disorder or antisocial behavior. Researchers want to see if the blended approach works just as well at reducing aggression, delinquency, and out-…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with schizophrenia who are overweight or obese and did not lose weight on metformin. About 92 participants will receive either semaglutide or a placebo. The main goal is to see if sema…

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This phase 2 trial tests whether a combination of intravenous immunoglobulin (IVIG) and rituximab can help people with psychosis caused by antibodies attacking the brain. 70 participants with acute psychosis and specific antibodies receive either the immunotherapy or a placebo. T…

This study aimed to test whether electronic cigarettes could help people with schizophrenia quit or reduce smoking. It planned to enroll smokers with schizophrenia from Sicily and compare e-cigarettes with nicotine, without nicotine, and a nicotine-free inhaler. However, the tria…

This study was designed to see if hyperbaric oxygen therapy or computerized cognitive training could help adults with Fetal Alcohol Spectrum Disorder (FASD) think and function better. It planned to enroll 0 participants and was withdrawn before starting, so no results are availab…

This study is testing a mobile app called Suubi-Mhealth for Ugandan teens aged 14-17 who have both HIV and depression. The app uses cognitive-behavioral therapy (CBT) to help improve mood and make it easier to stick with HIV medication. About 248 teens will take part to see if th…

This study tests a program called Minds and Mentors that combines mindfulness training with peer support to help people stick with their medication for opioid use disorder. About 240 adults currently on medication like methadone or buprenorphine will be randomly assigned to eithe…

This study tests whether a structured parent training program can reduce autism symptoms in children up to age 5 and high-risk infants under 2. 250 children and their caregivers will be randomly assigned to receive either the training plus routine care, or routine care alone. Aft…

This study tests whether a mix of treatments—including the patient's own stem cells, a strict keto diet, and a fecal transplant—can improve social skills, communication, and gut health in 50 teens and adults with autism. Participants must be stable on their current medications. T…

This trial tests a nurse-led health program for women aged 45 to 64 in Hong Kong. The program uses a 5-step approach (ask, advice, assess, assist, arrange) to help women manage conditions like high blood pressure, anxiety, and menopause symptoms. Researchers will compare the prog…

This study tests whether a 6-week exercise program, done twice a week, can improve physical and mental health in 100 adults with severe mental illness. Participants are randomly assigned to either usual care or usual care plus the exercise program. The goal is to see if exercise …

This study tests whether leucovorin calcium, a vitamin-like supplement, can improve language and other symptoms in young children with autism spectrum disorder. Researchers will enroll 80 children aged 2.5 to 5 years with language delays. The trial lasts about 26 weeks and compar…

This phase 2 trial tests whether rituximab, an anti-inflammatory drug used for conditions like multiple sclerosis, can improve symptoms in adults with schizophrenia spectrum disorders. About 123 participants aged 18-55 will receive rituximab or a placebo added to their usual trea…

This study compares two ways to help people with both substance use and mental health disorders: a full team-based program called MISSION that provides counseling, peer support, and community outreach for 6 months, versus just linking them with a peer specialist. Researchers hope…

This study tests a phone-based care management program for adults with depression, anxiety, or risky drinking. Participants get regular check-ins and support from a mental health technician, while their primary care doctor receives treatment recommendations. The goal is to see if…

This study tests whether a home-based program combining cognitive exercises (like puzzles) with mild brain stimulation can improve thinking and memory in older adults with mild cognitive impairment or late-life depression. About 40 participants will use the program at home with h…

This study tested a new approach for people with severe depression that hasn't improved with other treatments. A small wire was placed on the surface of the brain to send gentle electrical pulses to areas that control mood. The goal was to see if this is safe and could help reduc…

This study aims to reduce disparities in ADHD care by adapting an evidence-based school program with mobile health technology. Researchers will test the digital tool with 350 participants, including students, parents, teachers, and school mental health providers in low-income and…

This study tests whether taking a daily probiotic supplement can help people who were recently hospitalized for bipolar depression avoid another episode. 80 adults aged 18-65 will be randomly assigned to receive either the probiotic or a placebo pill for several months. Researche…

This study tests a 10-session program called AIM-AT, which uses acceptance-based techniques to help people with recent-onset psychosis better understand their illness and stick to their medication. The trial involves 126 participants in Hong Kong and tracks their medication adher…

This study explores whether people with schizophrenia resist the sedating effects of antipsychotic drugs like ziprasidone and olanzapine. Researchers give a single dose to both patients and healthy volunteers, then measure sleepiness, reflexes, and brain activity using EEG. If pa…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study explores whether a taste test can serve as a diagnostic tool for depression. Participants with untreated major depressive disorder will take a taste test before and after starting an antidepressant prescribed by their doctor, and again six to eight weeks later. The goa…

This study tests whether a Turkish translation of the Four-Dimensional Symptom Questionnaire (4DSQ) helps Belgian general practitioners who don't speak Turkish better diagnose depression and anxiety in Turkish-speaking patients with language barriers. About 80 patients and their …

This study tests whether a Samsung smartwatch can detect signs of depression by analyzing heart rate, sleep, and step count. About 220 adults with and without depression will wear the watch for 3 months and complete daily mood surveys. The goal is to see if the watch's 'Mindfulne…

This study tests whether a virtual group program called Mothers and Babies can prevent postpartum depression in immigrant Latinas who are at risk. About 300 pregnant women and new mothers will either join the program via Zoom or receive usual support services. Researchers will tr…

This study tests a 12-session program called Forging Hopeful Futures, designed to reduce violence among teens ages 13-19. The program uses group discussions and activities to help youth understand how racism, gender inequality, and economic injustice can lead to violence, and tea…

This trial tests a stepped-care intervention for mothers of young children enrolled in Head Start. The program aims to prevent depression in those with mild symptoms and help those with more severe symptoms connect to mental health services. Researchers will measure changes in de…

This trial asks whether the type of pain relief a woman receives during labor can influence her risk of developing postnatal depression. About 10-15% of new mothers experience postnatal depression, and this study compares epidural analgesia with non-epidural options like laughing…

This study tests two different programs designed to prevent depression in teenagers who are at risk. One program is an online course called CATCH-IT, and the other is an 8-session group program called TEAMS. About 636 teens aged 13-19 with mild depressive symptoms but no current …

This study tests a psychological empowerment program designed to prevent postpartum depression in pregnant women. 92 first-time mothers in Indonesia will take part in 5 group sessions over 3 weeks, focusing on control, confidence, and coping. Researchers will check if the program…

This study tests whether sulforaphane, a compound found in broccoli, can prevent psychosis in 300 people at high risk. Participants take either sulforaphane or a placebo daily for a year, then are followed for another year. The main goal is to see if fewer people in the sulforaph…

This study tests whether a short, modified exposure therapy given soon after rape can prevent post-traumatic stress disorder (PTSD) in women. About 166 women who have experienced sexual assault will be randomly assigned to either the brief therapy or standard care. The goal is to…

This study tests a 9-month mentoring program for 8th and 9th graders who have experienced child abuse or neglect and are involved with child welfare. The program pairs teens with graduate student mentors who help them set goals in relationships, education, activities, career, and…

This study involves 60 young people at high risk for psychosis. They receive a stepped series of psychological treatments, starting with the least intensive options like group support, and moving to more intensive therapy if needed. The goal is to prevent the development of psych…

This 7-year study tests whether a combination of mild electrical brain stimulation (tDCS) and computer-based memory exercises can slow mental decline and prevent Alzheimer's dementia. It involves 375 older adults with mild cognitive impairment or depression (both risk factors for…

This phase 3 trial tests a single oral dose of VQW-765 versus placebo for quickly reducing acute anxiety in adults with social anxiety disorder. About 500 participants will take the drug as needed before anxiety-provoking situations. The study measures distress levels during and …

This study is an extension of an earlier trial, testing the safety and tolerability of SPT-300 in 360 adults with major depressive disorder, with or without anxious distress. Participants who completed the prior study will receive SPT-300 for 6 weeks. The goal is to monitor side …

This study tests a telemedicine program called FOCUS that helps advanced cancer patients manage common symptoms like trouble sleeping, worry, tiredness, and low mood. The program uses counseling techniques delivered through a phone app. Researchers will enroll 120 adults with adv…

This phase 2 trial tests whether adding oxytocin nasal spray to standard psychosocial treatment can improve social skills and reduce symptoms in adults with schizophrenia spectrum disorders. Participants receive either oxytocin or a placebo spray alongside their usual therapy. Th…

This study tests a digital tool that helps parents of young children with developmental delays or disabilities organize and share their priorities with early intervention professionals. The tool, called PEM+, is designed to make family-centered care more practical by guiding fami…

This study tests whether a simple ear acupressure technique, called auricular point sticking therapy, can reduce anxiety and improve sleep in women undergoing IVF. 178 women aged 20-45 with anxiety or insomnia will either receive standard IVF care or standard care plus ear acupre…

This trial tests whether Written Exposure Therapy (WET), a brief six-session therapy involving guided writing about a traumatic event, can reduce PTSD symptoms in adults receiving care at Federally Qualified Health Centers. The study enrolls 720 English- or Spanish-speaking adult…

This Phase 3 trial tests whether two easy tests—measuring blood pressure changes when standing and eye reactions to light—can predict which veterans with PTSD will respond to the drug prazosin. The study involves 87 veterans and compares prazosin to a placebo. The goal is to pers…

This trial tests whether spending time in nature can reduce anxiety in children aged 9-12 who have experienced adverse childhood events. Participants are assigned to either group nature outings, family outings, or a waitlist. The goal is to see if these nature-based activities im…

This study tests whether using a hand extension rubber during IV insertion can reduce pain, anxiety, and improve satisfaction. Researchers will enroll 114 adults who need an IV and randomly assign them to use the rubber or not. The goal is to see if this simple, low-cost distract…

This study explores whether Child-Parent Psychotherapy (CPP) is a practical and helpful treatment for children aged 0-6 who are in foster care and have experienced traumatic events. The therapy involves the child and their caregiver working together to reduce trauma symptoms and …

This study tests a group version of the Feeling Safe Programme, a type of cognitive behavioral therapy for people with schizophrenia or schizoaffective disorder. The goal is to reduce distressing symptoms like paranoia and hallucinations and improve quality of life. Fifty partici…

This small study tests a new treatment called TEST for people with depression that hasn't improved with standard treatments. TEST uses a lower electric current than standard electroconvulsive therapy (ECT), aiming to avoid memory and thinking problems. Eight adults aged 25-64 wil…

This trial tests whether a brief program called CALM, delivered by school nurses, can reduce excessive anxiety in children aged 5 to 12. The program teaches relaxation, facing fears, and changing anxious thoughts over eight weeks. It is compared to a relaxation-only approach and …

This trial tests a counseling program called Mpata Yathu ('Our Space') for adolescent girls and young women in Zambia who have experienced gender-based violence and may be living with or at risk for HIV. The program uses problem-solving therapy delivered by trained lay counselors…

This study tests an experimental oral drug called CYB003 in 220 adults with major depressive disorder. Participants receive either CYB003 or a placebo alongside their usual treatment. The goal is to see if CYB003 safely reduces depression symptoms better than placebo.

This study compares two internet-based cognitive behavioral therapies for people with generalized anxiety disorder. 400 adults will receive one of two 10-week online programs, guided by a psychologist. The goal is to see which therapy reduces anxiety more and whether they work by…

This study tests whether a 10-week program called Positive Minds, Strong Joints is feasible for Black adults aged 50 and older with knee osteoarthritis. The program combines recommended exercise with mental health strategies to address pain, depression, and anxiety. Researchers w…

This study tests whether using a special augmented reality (AR) game called Little NIRVANA, along with numbing cream, can help children ages 2 to 8 feel less pain and anxiety when getting an IV in the emergency room. About 130 kids will be randomly assigned to get either the AR g…

This study tests an experimental drug called RAP-219 for people with bipolar I disorder who are currently experiencing a manic episode. About 250 participants will receive either RAP-219 or a placebo daily for 21 days. Researchers will measure changes in manic symptoms using a st…

This study explores whether a type of improvised music, designed with calming sound parameters, can reduce anxiety in people with Alzheimer's disease and in healthy adults. Researchers will measure changes in anxiety scores, blood pressure, and heart rate before and after listeni…

This study tests whether a nerve block given before surgery (TAP block) works as well as numbing medicine injected into the wound by the surgeon for controlling pain after gynecologic cancer surgery. About 80 women having surgery through a vertical belly cut will take part. The g…

This study tested a school-based program called Proud & Empowered, designed to help LGBTQ students cope with minority stress and improve mental health. About 228 high school students took part. The program was led by school counselors and social workers. The study was terminated …

This study tests an oral medication called MM120 against a placebo in adults with major depressive disorder. The trial has two parts: a 12-week blinded phase followed by a 40-week open-label extension where everyone gets MM120. The main goal is to see if MM120 reduces depression …

This study tests an oral medication called MM120 against a placebo in 245 adults with generalized anxiety disorder. Participants take the drug or placebo for 12 weeks, and those who complete may join a 40-week follow-up where everyone gets the active drug. The goal is to see if M…

This trial tests whether a virtual reality (VR) educational video can reduce anxiety and improve satisfaction in adults starting their first course of external beam radiotherapy for cancer. Half of the 122 participants will watch a VR video through a headset before treatment, whi…

This trial tests whether listening to music for 30 minutes before and after surgery can reduce pain, anxiety, and the need for painkillers in women undergoing gynecologic surgery. Participants will choose from several music genres and report their pain, anxiety, and satisfaction …

This study tests an online pathway called iPath*D that guides cancer patients who report depression symptoms from screening to treatment options. The goal is to see if the tool is acceptable and easy to use for adults starting cancer treatment. Researchers will measure usability,…

This trial tests whether nurse-guided breathing exercises can reduce shortness of breath and anxiety in people with advanced heart failure who come to the emergency department. Participants are randomly assigned to receive either standard care plus guided diaphragmatic and pursed…

This trial tests whether using virtual reality (VR) relaxation before and after gynecologic surgery can reduce anxiety and pain. About 220 women undergoing day or inpatient gynecologic procedures will either use a VR headset with calming scenes or receive standard care. Researche…

This study tests whether a 10-week internet-based cognitive behavioral therapy program can improve quality of life and reduce ADHD symptoms in adults. Two hundred adults in Sweden who have been diagnosed with ADHD and are working or studying will be randomly assigned to either th…

This study tests whether a 12-week mobile app program can improve thinking skills and motivation in people with early psychosis. About 400 participants already receiving coordinated specialty care will either use the app or continue standard care. Researchers will track changes i…

This study tests whether mild electrical stimulation of the ear, combined with physical and speech therapy, can improve symptoms like voice problems, swallowing, and balance in people with Parkinson's disease. 46 participants will receive either active or sham stimulation during …

This early-stage study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely help autistic adults with depression that hasn't improved with other treatments. Twenty participants will receive two doses of psilocybin along with ab…

This study tests whether two simple, drug-free techniques can ease the pain, fear, and crying that 9-month-old babies often experience during routine vaccinations. One method uses a small bee-shaped device called Buzzy, which vibrates and cools the skin near the injection site. T…

This study is testing whether a daily practice of Tao Calligraphy meditation and drinking so-called 'energized water' can improve symptoms of unipolar depression in adults. Fifty participants will be split into two groups to compare the effects over 12 weeks. The goal is to see i…

This study tests whether a non-invasive magnetic brain stimulation technique, called rTMS, can help ease depression in people with Parkinson's disease. Fifty adults with mild to moderate depression will be randomly assigned to receive either real rTMS or a sham (fake) treatment f…

This study tests whether a smartphone app called AIM+ can help juvenile justice officers and other professionals who work with youth in the legal system manage chronic stress, anxiety, and burnout. Over 30 days, participants use the app for short guided meditations and videos. Th…

This study looks at whether using the Calm meditation app for 10 minutes a day can help blood cancer patients who have trouble sleeping. Researchers will track sleep, mood, and inflammation in 276 participants over 20 weeks. The goal is to find a simple, drug-free way to improve …

This study tests a new way to deliver an FDA-approved treatment called TMS (transcranial magnetic stimulation) for depression in adults aged 60 to 79. Researchers use fMRI brain scans to personalize the treatment target. The goal is to improve depression symptoms and brain connec…

This study tests whether a device called CES (cranial electrotherapy stimulation) can reduce anxiety symptoms in 200 active-duty military members and their families. Participants receive either real CES or a sham (placebo) device to see if the gentle electrical pulses truly help.…

This study tests whether an 8-week online Mindfulness-Based Stress Reduction (MBSR) program can help healthcare professionals recover from work-related stress and reduce burnout. Participants who provide direct patient care will either join the online program or be placed on a wa…

This study tests a version of the RUBI parent training program that has been adapted for Spanish-speaking families of autistic children aged 2 to 9. About 120 parents will join eight online group sessions to learn practical strategies for managing challenging behaviors. Researche…

This trial compares two forms of cognitive-behavioral therapy (CBT) for children and teens with anxiety or obsessive-compulsive disorder (OCD). One approach uses internet-delivered modules with therapist guidance; the other trains parents to lead exposure exercises with their chi…

This trial tests a 12-session cognitive-behavioral therapy designed to help people with substance use who also struggle with anxiety or depression. The therapy focuses on improving emotion regulation—the ability to understand and manage emotions—which may reduce addictive behavio…

This study tests a coach-guided digital therapeutic called Toivoa-004, designed to help adults with Long COVID manage symptoms of anxiety and depression. The program delivers cognitive behavioral therapy through a smartphone app and is built to be accessible for people with disab…

People on hemodialysis need their fistula punctured with a needle three times a week, which can be painful and anxiety-provoking. This trial compares three approaches: usual care, applying an ice pack to a specific point on the hand before the needle, and using a numbing gel. Res…

This trial tests a web-based sex and relationship education program called Our Love, Our Style (OLOS) for autistic young adults in South Korea. Participants start with either web-based learning alone or web-based learning plus group coaching. Based on their progress, non-responde…

This pilot study explores whether robot-assisted walking devices can be used in schools to help children who cannot walk independently. The devices attach to a walker and power leg movements, allowing children to stand and walk upright. The study aims to identify the best ways to…

This pilot study asks whether the antibiotic minocycline, the supplement N-acetylcysteine (NAC), or both together can ease depression in people with bipolar disorder. Participants continue their usual mood stabilizer while receiving one of the treatments or a placebo. The goal is…

This study tests whether eye-tracking can predict if the drug brexpiprazole will improve symptoms in adults with major depressive disorder. One participant will take brexpiprazole or placebo while researchers measure their visual attention to emotional images. The goal is to see …

This trial tests whether a structured psychoeducational program can reduce psychological distress and caregiver burnout in family caregivers of individuals with bipolar disorder. Thirty primary caregivers aged 25–40 who have provided care for at least one year will attend therapi…

This trial tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can reduce anxiety in people with Parkinson's disease. Anxiety affects up to 40% of people with Parkinson's, and standard medications often fall short or cause side …

This early-stage trial is testing whether a non-invasive procedure called focused ultrasound can safely reduce both seizures and anxiety in people with treatment-resistant epilepsy. The ultrasound targets a small region in the brain thought to be involved in both conditions. Rese…

This study follows children and adolescents with fetal alcohol spectrum disorder (FASD) who have already completed a dog-assisted therapy program. Researchers want to see if improvements in social skills, behavior, emotional well-being, and quality of life persist over 12 months.…

This study compares a structured pulmonary rehabilitation program — including breathing exercises, aerobic conditioning, and education — against standard medical care for people with pericarditis (inflammation around the heart). The goal is to see if the program can reduce chest …

This study tests whether giving a medicine called dexmedetomidine during a second-trimester dilation and evacuation (D&E) can lower the chances of severe grief and post-traumatic stress after the procedure. About 100 people having a D&E in the operating room will be randomly assi…

This study tests whether acceptance and commitment therapy (ACT) helps adults with chronic non-malignant pain (pain lasting 3+ months not caused by cancer). Sixty participants are randomly assigned to ACT, cognitive behavioral therapy (CBT), or standard medical care alone. Both A…

This study tests whether an 8-week online mindfulness program (MBSR) can improve emotional intelligence and reduce stress-related physical symptoms in adolescents aged 14 to 18 who have experienced bullying and childhood trauma. About 44 teens are randomly assigned to either the …

This study tests whether trained older adult peer coaches can help people aged 60+ who have both depressive symptoms and subjective cognitive decline (memory concerns). Participants take part in 8 weekly video chats focused on emotional and practical support. The goal is to see i…

This study investigates whether adding structured exercise groups to standard care improves mood, anxiety, energy, and sleep in adults hospitalized for psychiatric conditions. Participants take part in a 30-minute exercise session led by an occupational therapist, including warm-…

This study at Johns Hopkins tests whether using personalized mobile health assessments can improve cognitive-behavioral therapy (CBT) for children aged 8-17 with obsessive-compulsive disorder (OCD). 30 participants will receive either standard CBT or CBT guided by their own sympt…

This study tests whether very small, daily doses of psilocybin (the active ingredient in magic mushrooms) can safely reduce anxiety and depression in people with advanced illnesses receiving palliative care. Twenty participants will take oral capsules (1-3 mg per day, Monday to F…

This study investigates whether a hemp-derived cannabidiol (CBD) extract can safely reduce anxiety and improve sleep in adults with moderate to severe anxiety. Over four weeks, participants take 50 to 150 mg of CBD daily, with doses adjusted based on tolerance. The trial tracks s…

This trial investigates whether combining two types of brain stimulation—intermittent theta burst stimulation (iTBS) and high-definition transcranial direct current stimulation (HD-tDCS)—can reduce negative symptoms of schizophrenia, such as lack of motivation, social withdrawal,…

This study tests whether a smartphone app can help adults who are hospitalized for depression or suicidal thoughts. After leaving the hospital, participants use the app for 28 days to practice skills that encourage positive activities. The goal is to see if the app is easy to use…

This study tests whether therapeutic touch — a gentle, energy-based technique — can improve breastfeeding confidence, strengthen the emotional bond between mother and baby, and lower the risk of postpartum depression in first-time mothers. Researchers will compare a group receivi…

This study tests whether a non-invasive device that stimulates the vagus nerve can reduce pain and anxiety and improve quality of life for burn patients during dressing changes. About 96 adults with second-degree burns will be randomly assigned to receive the stimulation before o…

This study looks at whether a non-invasive device that stimulates the vagus nerve can improve anxiety, sleep, pain, and itching in teenagers aged 12-18 who have had burn injuries. About 60 participants will either get this stimulation plus standard physical therapy, or just stand…

This study tests whether training early intervention providers in Reciprocal Imitation Training can help children with autism improve imitation and communication skills. The program involves 440 children and their caregivers, with providers learning simple strategies during play.…

This trial tests whether an AI-powered chatbot can help reduce anxiety and improve coping in men about to have prostate cancer surgery. Participants will either receive standard preoperative communication or also have access to a large language model (LLM) that answers their ques…

This study tests whether a short video and a 3-week text messaging program can help people who have recently experienced sexual assault. The goal is to see if these tools can reduce mental health problems like PTSD and prevent misuse of opioids and other substances. About 394 adu…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce anxiety, improve sleep, and lessen pain and itching in adults recovering from burn injuries. About 60 participants will either get standard physical therapy plus this nerve st…

This study tests whether structured hypnotherapy sessions can improve quality of life for women with breast cancer undergoing chemotherapy. Participants in the intervention group receive 10 hypnotherapy sessions alongside standard care, while the control group receives standard c…

This study tests a drug called neflamapimod in 20 people with a language disorder called nonfluent variant primary progressive aphasia (nfvPPA). The goal is to see if the drug is safe and if it can improve language symptoms. Participants will receive either the drug or a placebo …

This study tests whether listening to special audio fairy tales before sleep can improve speech, motor skills, and independence in a child with autism and central auditory processing disorder. The child stays at home with their mother, avoiding clinic stress. Early results from t…

This study explores whether joining a weekly reading group can improve reading comprehension and communication confidence in adults with aphasia, a language disorder often caused by stroke. Participants read a book at home and then discuss it in a 90-minute group session each wee…

This study explores whether adding a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) to standard speech therapy can improve word-finding in people with aphasia after a stroke. The trial involves 50 adults who are at least six months …

This study investigates whether using a stress ball during port catheter needle changes can reduce pain, anxiety, and improve satisfaction in cancer patients. Fifty adult oncology patients will be randomly assigned to either use a stress ball or receive standard care. The goal is…

This study tests whether smelling essential oils during skin surgery can reduce the unpleasant smell of burnt flesh from electrocautery and lower patient anxiety. About 111 adults having same-day skin procedures will be randomly assigned to receive either a real essential oil inh…

This study explores whether a new type of group therapy, based on Eastern cultural practices, can help people with anxiety disorders. Researchers will enroll 60 participants aged 15 to 55 to test the therapy's effects on anxiety symptoms. The goal is to see if this approach is bo…

This study tests whether a smartphone app that delivers cognitive behavioral therapy (CBT) can help adults with social anxiety disorder. Participants use the app for 12 weeks, learning skills like cognitive restructuring and exposure exercises. The trial compares app users to a w…

This study tests whether DHA, a key omega-3 fatty acid found in fish oil, can improve symptoms of autism in children and adolescents aged 5 to 17. Participants receive either DHA or a placebo daily for 12 weeks. Researchers also look at genes and urine markers related to DHA to u…

This study explores whether high-intensity interval training (HIIT) is a practical and acceptable treatment for adults with ADHD. Researchers will recruit 30 adults diagnosed with ADHD to participate in a 14-week exercise program combining strength and endurance training. The goa…

This study tests an internet-based cognitive behavioral therapy (CBT) program designed to help autistic adolescents aged 11-17 manage anxiety. The program, called LUNA-Adolescent, is parent-led and delivered online, making it easier for families who cannot access in-person therap…

This study looks at two ways to lower anxiety in children aged 3 to 10 who need surgical pins removed from an elbow fracture. One approach removes the pins right after the cast comes off, before an X-ray, instead of after. The other uses a virtual reality headset during the pin r…

This study tests an 8-week online stress management program for health students in Sfax, Tunisia. The program combines cognitive-behavioral therapy and mindfulness meditation through videos, exercises, and motivational messages. Researchers will measure changes in stress, anxiety…

This study compares a shorter therapy focused on guilt (TrIGR) to a standard PTSD therapy (CPT) in 160 U.S. Veterans. The goal is to see if TrIGR is no less effective at reducing PTSD, depression, and guilt symptoms. Participants are randomly assigned to one of the two treatments…

This trial explores whether spending time on a farm with animals and nature can help socially withdrawn young adults (ages 18–30) with autism spectrum disorder. Participants take part in supervised group activities on a farm twice a week for 12 weeks. Researchers will interview p…

This early-phase trial tests whether inhaling a low dose of xenon gas can quickly improve depressive symptoms in 20 people with treatment-resistant major depression or bipolar depression. Participants receive either xenon or a placebo gas added to their usual treatment, and resea…

This study tests whether wearing a virtual reality (VR) headset during dental treatment can reduce fear and stress in children with mild intellectual disabilities or autism spectrum disorder. Two hundred children aged 6 to 12 will either receive standard dental care or use a VR h…

This study tests a new virtual reality program designed to help adults with autism improve their social skills and daily functioning. 140 participants will either receive the VR training plus usual care, or usual care alone, for 3 months. Researchers will measure changes in socia…

This study tests a new method called Strategic Treatment Assessment for Youth (STAY) designed to help racial and ethnic minority teens with depression or suicidal thoughts stay in therapy. Researchers will compare STAY to standard care in 140 teens aged 12-18 across three communi…

This study tests whether a pelvic floor massage technique (Thiele massage) can reduce pain during sex in women with chronic pelvic pain. It compares in-person treatment with guided self-massage at home via telehealth. The goal is to see if telehealth can be as effective as in-per…

This study tests a behavioral program called SWITCH that teaches people with serious mental illness (like depression, schizophrenia, or bipolar disorder) to set goals, use rewards, and build habits to do more activities outside the home. 52 participants will attend weekly online …

This study tests whether a unique music therapy, based on Traditional Chinese Medicine's five-element theory, can help men with depression and anxiety when added to their usual medication. One hundred male inpatients will receive either standard drugs alone, drugs plus regular mu…

This study tests whether simple distraction tools—a ShotBlocker device and a finger puppet—can reduce pain and fear in children aged 5 to 10 during blood draws. About 90 children will be randomly assigned to use one of these tools or receive standard care. The goal is to see if t…

This study aimed to see if a web-based self-help program called Deprexis could help orthopedic patients with major depressive disorder. The plan was to offer the 8-week online program to patients with depression and see if they would use it and if their mood and physical function…

This study tests whether real-time brain scans (fMRI) can help people with depression learn to reduce rumination—repetitive negative thinking. 80 participants will receive either real or sham neurofeedback while in a powerful 7T MRI machine. The goal is to strengthen a specific b…

This study tests whether a digital cognitive behavioral therapy program, supported by telephone coaching, can help reduce depression symptoms in pregnant women. About 634 mothers with mild to moderate depression were randomly assigned to either the guided digital program or stand…

This study explores whether a photography-based program can help children aged 8-12 with ADHD better recognize and express emotions, and improve attention and impulsivity. Sixty children will take photos and learn photography skills as a tool to boost emotional well-being. The go…

This study tests whether a mobile app for PTSD, along with brief weekly support sessions, can help people who are already in treatment for alcohol problems. About 300 adults with both PTSD and alcohol use disorder will use the app or receive standard care. Researchers will track …

This study tests a structured 8-session group therapy called Integrated Grief Therapy (IGT) for adults who lost loved ones in the 2023 Türkiye earthquake. 190 survivors were randomly assigned to either the therapy or a waitlist. The goal is to see if the therapy boosts resilience…

This study tests whether chamomile or valerian extracts can reduce dental anxiety in healthy children aged 6 to 10 who need a tooth pulled. Kids are randomly given one of the herbal extracts or a placebo before the procedure. Researchers measure anxiety using child-friendly emoji…

This Phase 2 trial tests a single intravenous dose of ketamine in 20 hospitalized teens and young adults with anorexia nervosa or atypical anorexia. Researchers want to see if ketamine helps the brain become more flexible, making it easier to learn new, positive associations with…

This study tests whether virtual reality (VR) brain exercises can help people with schizophrenia or bipolar disorder think more clearly and function better in daily life. 80 adults will either receive VR training twice a week for 12 weeks or continue their usual care. Researchers…

This study tests a single online session that teaches a simple coping skill to youth ages 9-17 who are on a waitlist for therapy. The goal is to see if this quick digital tool can help ease symptoms of anxiety, depression, and stress while they wait. About 226 youth and their par…

This study tests a speech therapy method called Rapid Syllable Transition (ReST) in children aged 5 to 8 with childhood apraxia of speech, a condition that makes it hard to say sounds correctly. The goal is to see if the therapy is practical and helps improve speech clarity and m…

This study tests a therapy called RETELL that helps people with severe mental illness explore and reshape their life stories. The goal is to improve personal recovery, quality of life, and identity. Twenty adults with conditions like schizophrenia, bipolar disorder, or PTSD will …

This study looks at whether a guided relaxation practice called Yoga Nidra can lower stress, anxiety, and sleep problems in nursing students during their hospital training. About 110 fifth-year nursing students will take part. Researchers will measure changes using questionnaires…

This study tests an 8-week program called Step-CBT that combines physical activity goals with cognitive behavioral therapy for veterans with COPD who also have depression or anxiety. The program is delivered via video calls to make it accessible. Researchers want to see if it is …

This study tests whether a probiotic supplement called Neuralli® MP can help adults aged 18 to 50 who have autistic traits. Participants take two capsules daily and set their own personal goals to track progress. The trial is small and open-label, meaning everyone knows they are …

This study tests whether a device that sends mild electrical pulses to facial muscles can help treat major depression. Twenty adults with depression will use the device at home for 45 minutes daily over four weeks. The main goal is to see if the approach is feasible and safe, wit…

This study tests whether a short, intensive course of cognitive behavioral therapy (CBT) over 2 weeks works better than the usual weekly sessions over 6 months for people with anxiety disorders. 120 adults with conditions like panic disorder, OCD, or PTSD will be randomly assigne…

This study tests a 12-session group program called Family Connections Transdiagnostic for relatives of people with emotional dysregulation disorders (like eating disorders or personality disorders). The program teaches skills in mindfulness, emotional regulation, and problem mana…

This study tests whether a single injection of ketamine can quickly reduce suicidal thoughts in people with depression who come to the emergency room. About 90 participants will receive either ketamine or a sedative (midazolam) and be monitored for 24 hours. The trial is currentl…

This study tests a free app called LightBEAM that offers videos, forums, and exercises to help parents manage stress, anxiety, and depression. About 300 Canadian parents of children aged 18 months to 9 years will use the app for 12 weeks. The goal is to see if the app improves pa…

This study planned to see if using virtual reality (VR) before a brain stimulation treatment called TMS could help people with OCD feel more comfortable. It was designed for adults already approved for TMS. However, the study was withdrawn before any participants were enrolled, s…

This study aimed to see if a voice-changing device could make exposure therapy easier for people with PTSD. Patients would read their trauma story aloud while software altered their voice's emotional tone, hoping to reduce distress. The study was withdrawn before any participants…

This study tests whether a more targeted form of transcranial magnetic stimulation (TMS) can help people with schizophrenia whose symptoms don't improve with medication. The treatment uses each patient's own brain wave frequency (alpha rhythm) and MRI scans to precisely stimulate…

This study tests whether 80 sessions of a gentle brain stimulation technique called tDCS, given over 12 months, can improve attention, social skills, and language in 180 children aged 6 to 11 who have autism along with rare diseases, genetic problems, or PANDAS. The treatment is …

This pilot study tests whether an 8-week mindfulness program (MBSR) can reduce anxiety, depression, and stress in people with COPD who are already in pulmonary rehab. About 44 participants will be followed for 12 months. The goal is to see if this mind-body approach improves emot…

This study tests whether combining transcranial magnetic stimulation (TMS) with virtual reality exercises and physical therapy can improve symptoms like balance, fatigue, and thinking in people with multiple sclerosis. Thirty participants will receive both real and sham TMS in a …

This study looks at whether an 8-week yoga program during pregnancy can lower the risk of postpartum depression and strengthen the bond between mother and baby. It involves 60 first-time mothers who are 26-28 weeks pregnant. Participants will either take yoga classes or receive s…

This study tests a new device that uses mild electrical currents to stimulate the brain in people with major depression. The device adjusts the stimulation in real time based on brain activity. The goal is to see if the device works correctly and if it can help reduce depression …

This study looks at whether changing the sound of your own voice (like adding echo or whisper) can help adults who stutter speak more smoothly. About 100 people will use a special app for one month. The goal is to see if this simple technique improves fluency over time.

This study tests whether a nurse-led sailing program can improve resilience, self-esteem, and social skills in school-aged children with autism. About 184 children aged 7 to 12 will either take part in a 6-day sailing program or do simple craft activities. Researchers will compar…

This study tests whether a virtual reality (VR) program can help people undergoing bone marrow transplants cope with stress and improve their quality of life. About 80 adult patients with blood cancer will be randomly assigned to either receive the VR program plus usual care, or …

This study looks at whether tapping the skin before a shot (the Helfer Skin Tap Technique) can lower pain and boost comfort during a muscle injection. About 60 adults getting a common painkiller injection will be randomly assigned to either the tap method or standard injection. P…

This pilot study tests a youth-adapted therapy called NECT-Y to see if it can reduce self-stigma in 96 young people with bipolar disorder or multiple mental health conditions. Participants will either join a 14-week virtual group therapy or continue their usual care. The main goa…

This study tests whether an online cognitive behavior therapy (CBT) program can help children aged 8 to 17 with asthma who also feel anxious or worried about their condition. The therapy is designed to improve quality of life, reduce anxiety, and help manage asthma better. The st…

This study tests a mindfulness program (called GEM) delivered through an app and weekly group video calls. It aims to see if young adults (ages 18-24) who have faced early life hardships find the program helpful and easy to use. The study also checks if the program reduces sympto…

This study tests whether a virtual reality program that teaches mindfulness, self-compassion, and understanding others can help people with mood, anxiety, or psychotic disorders feel more at ease in social situations. Researchers are enrolling 174 college students and healthcare …

This study was designed to test a new pain medicine called HTX-011 in children and teens (ages 3 to 17) after hernia surgery. The goal was to see how well it controls pain and how safe it is. However, the study was withdrawn before any participants were enrolled, so no results ar…

This study looks at whether giving vitamin D supplements to women with depression and low vitamin D levels can change their brain waves. Researchers will measure brain activity using a non-invasive EEG scan before and after supplementation. The trial includes 34 women aged 20-40 …

This small pilot study at Yale University is testing a modified form of cognitive-behavioral therapy (CBT) for children with autism and intellectual disability who struggle with irritability, tantrums, and aggression. Up to 6 children aged with an IQ between 55 and 85 will receiv…

This trial aimed to test an online version of Acceptance and Commitment Therapy (ACT) for adults with disorders of gut-brain interaction (like IBS) who also have anxiety or depression. Participants would have been randomly assigned to either the ACT program or an online education…

This early study tests whether gentle ultrasound waves aimed at the amygdala (a brain region linked to emotion) can help people with bipolar disorder. Twenty adults with bipolar will receive the ultrasound and have brain scans to see if it calms overactive emotion circuits. The g…

This study tests whether a brief digital task can reduce the number of upsetting, involuntary memories that women experience after a traumatic event. About 380 women from Iceland who have at least three such memories per week will be randomly assigned to one of three groups: a me…

This study tests whether listening to specific sound frequencies for just 9 minutes a week can improve mental health. 110 adults with mild anxiety, stress, or depression will either sit in a special sound chamber or use headphones. The goal is to see if this simple, drug-free app…

This study tests whether teaching parents of children with autism special behavior support techniques can reduce challenging behaviors and lower parenting stress. About 80 families in South Punjab, Pakistan, will take part in an 8-10 week program. The goal is to see if this appro…

This study tests a new medication (CTx-1301) for children aged 6 to 12 with ADHD. The goal is to see if it helps control symptoms like inattention and hyperactivity over a full school day. Children will take the drug or a placebo and be observed in a lab classroom for 14 hours. T…

This study tests a 4-session group program called the Rational Positive Parenting Program (s-rPPP) for mothers of children aged 6-12 with disruptive behaviors like aggression and defiance. The program teaches parents to change unhelpful beliefs and manage emotions to improve chil…

This study aimed to see if trazodone works better than quetiapine or a placebo for treating confusion (delirium) in adult surgical ICU patients. It planned to measure how long delirium lasts, sleep quality, and side effects. However, the study was withdrawn before enrolling any p…

This study tests whether giving different numbers of daily brain stimulation sessions (rTMS) can safely improve symptoms in people with moderate to severe depression that hasn't responded to other treatments. One hundred adults will receive 4, 6, 8, or 10 sessions per day for 5 d…

This study tests whether a non-invasive device that gently stimulates the vagus nerve through the ear can improve speech recovery in people with aphasia after stroke or brain injury. Twelve adults with apraxia of speech will receive either active or sham stimulation during 16 wee…

This small pilot study tests whether Imagery Rescripting, a therapy that helps people change negative mental images, can reduce depression and negative beliefs. Ten adults with major depressive disorder will receive weekly sessions after a waiting period. The study tracks depress…

This study tests a guided mental health chatbot called STARS, designed to help young people aged 18-25 in Lithuania who are feeling anxious or depressed. About 262 participants will use the chatbot and researchers will measure changes in their symptoms. The goal is to see if this…

This trial aimed to see if heart rate variability biofeedback training (using a smartphone app) could reduce stress and anxiety in university students as well as or better than guided meditation. The study planned to enroll second- and third-year physiotherapy students and measur…

This study tests a program that combines family group sessions with a virtual peer mentoring program for US-born teens (ages 14-17) whose parents resettled as refugees. The goal is to reduce symptoms of PTSD, depression, anxiety, and behavior problems caused by intergenerational …

This study aimed to see if high-dose DHA (an omega-3 fatty acid) could reduce involuntary movements in people with tardive dyskinesia, a side effect of long-term antipsychotic medication. It planned to enroll 40 adults aged 30-75 with schizophrenia and tardive dyskinesia, giving …

This study planned to test whether a brain-computer interface (BCI) could help children with drug-resistant epilepsy improve their attention. Participants would have used brain electrodes already implanted for epilepsy surgery to train a decoder that gives real-time feedback when…

This study tests whether a mild electrical brain stimulation technique called tDCS can improve musical performance and reduce stage anxiety in 24 young orchestra players aged 18-30. Participants receive either real or fake (sham) stimulation before playing a piece, and their perf…

This study tests whether an 8-session intermodal art therapy program can lower depression, anxiety, and stress while improving emotion regulation in nursing students. Forty-four first- and second-year students from Istanbul Atlas University will be randomly assigned to either the…

This study planned to test whether a lidocaine nerve block (SPG block) could reduce anxiety in adults at electronic dance music festivals, compared to a saline placebo. The trial was withdrawn before enrolling any participants, so no data were collected. The approach was experime…

This pilot study tests whether a type of brain stimulation called accelerated continuous theta-burst stimulation (acTBS) can reduce suicidal thoughts in people hospitalized for depression. Forty inpatients will receive either real or sham (fake) stimulation up to 5 times a day fo…

This study tests a brief digital mental health program for people on waiting lists for psychological treatment. About 80 participants will be randomly assigned to one of four groups: a short program (30-40 minutes), a longer version, or control conditions. The main goal is to see…

This study tests whether folinic acid (leucovorin), a drug already used to reduce side effects from chemotherapy, can improve language skills in children with autism spectrum disorder. Researchers will give the drug or a placebo to 56 children aged 5 to 17 for 12 to 24 weeks and …

This pilot study tests whether a short, 5-session writing therapy called Written Exposure Therapy (WET) is practical and helpful for pregnant or postpartum adolescents and young adults (ages 15-24) with PTSD. The therapy involves writing about traumatic experiences with minimal t…

This study tests an online self-help program called Together After Cancer for Latina breast cancer survivors and their intimate partners. The program includes brief coach calls and aims to improve the survivor's quality of life and the couple's relationship satisfaction. About 48…

This pilot study tests whether using a soft baby carrier for extra physical contact helps mothers with prenatal anxiety or depression feel more connected to their baby. Forty moms in Montreal will either use the carrier or be on a waitlist. Researchers will measure bonding, brain…

This early-phase study looks at whether Emotional Freedom Techniques (EFT) — a practice that combines tapping on acupressure points with counseling — can reduce anxiety, depression, pain, and insomnia in people with cholangiocarcinoma, a rare and aggressive bile duct cancer. Four…

This study tests whether D-serine, a natural brain chemical, can improve learning and memory in people with schizophrenia. Participants take D-serine or a placebo for 16 weeks while doing auditory training exercises. The goal is to see if D-serine helps the brain adapt and learn …

This study tests a 12-session group therapy program (G-BCBT) for active duty military personnel who have recent suicidal thoughts or a recent suicide attempt. The therapy teaches emotion regulation, cognitive flexibility, and relapse prevention skills. Researchers will measure ch…

This study looks at whether music therapy can help children and teenagers with mood disorders who also hurt themselves (called non-suicidal self-injury, or NSSI). About 54 participants will take part, and researchers will use questionnaires, brain scans, and electrical brain acti…

This study aimed to see if a telehealth skills group could help middle and high school students with ADHD improve their organization, motivation, and grades. Both the treatment and control groups were delivered via Zoom. However, the study was withdrawn before enrolling any parti…

This study explores whether music therapy can reduce anxiety, fatigue, and other symptoms in women with breast cancer who are receiving chemotherapy. Twenty-four participants will take part in weekly group music sessions and use personalized playlists at home, alternating periods…

This study looks at whether using a mindfulness app on a smartphone for 8 weeks can improve mental health in Korean immigrants aged 60 and older. Participants use the app for about 10-15 minutes daily and have weekly check-ins. The goal is to see if the app is easy to use and hel…

This study aimed to see if having a parent appear on a video call during anesthesia induction could reduce children's anxiety as effectively as the sedative midazolam. It was designed for children aged 4 to 8 undergoing outpatient surgery. However, the study was withdrawn before …

This study compares two brain stimulation treatments—electroconvulsive therapy (ECT) and magnetic seizure therapy (MST)—for people with severe depression that hasn't improved with standard medications. About 100 adults with major depression or bipolar depression will receive one …

This study tests whether wearing virtual reality glasses during IUD insertion can lower pain and anxiety. About 114 women will be randomly assigned to use the glasses or not. Researchers will measure pain on a 0-10 scale and anxiety with a standard questionnaire.

This study tests whether a specially designed group yoga program is practical and helpful for adults with ADHD symptoms. Twenty participants will be randomly assigned to either yoga or general movement classes. Researchers will track how many people join, stay, and complete the p…

This study tests whether using a virtual reality (VR) relaxation session can lower anxiety in people about to receive electroconvulsive therapy (ECT). Twenty adults already receiving ECT for depression will try VR relaxation, breathing exercises, or no extra relaxation. Researche…

This study tests whether an accelerated schedule of transcranial magnetic stimulation (TMS) is safe and effective for treating symptoms of psychotic disorders like schizophrenia. About 20 adults aged 18-65 with schizophrenia, schizoaffective disorder, or at high risk for psychosi…

This study looks at whether progressive muscle relaxation exercises can improve sleep, reduce anxiety, and help body image in people with burn injuries. About 100 adults with second-degree burns will either do these exercises twice daily for a week or receive standard care. The g…

This study tests whether the Apollo System, a device, can reduce ADHD symptoms in children aged 8 to 17. About 100 kids with diagnosed or suspected ADHD will use the device or a placebo version. Researchers will measure changes in attention and hyperactivity using parent surveys …

This study tests a 6-session virtual program called Future Self-BD for adults with bipolar disorder who want to quit smoking. Participants are guided to vividly imagine positive future events that could result from quitting, combined with brief smoking cessation counseling. The t…

This study tests whether a 16-session program called HOPS can help 6th to 8th graders with ADHD improve their organization, time management, and planning skills. Researchers are working with 240 students and their teachers in real school settings to see if the program works outsi…

This pilot study tests two 4-week smartphone treatments for social anxiety, one using psychodynamic therapy and the other cognitive behavioral therapy, both guided by an AI chatbot instead of a human therapist. 90 adults with social anxiety are randomly assigned to one of the two…

This study tests whether a gentle ultrasound beam aimed at the brain can reduce anxiety. 44 people with high or low anxiety will receive either real or fake ultrasound while their reactions to stressful tasks are measured. The goal is to see if this noninvasive technique can damp…

This study tests a community-based program called CRISOL Mente to help Latinos in the Philadelphia area with depression, anxiety, or PTSD. The program uses outreach workers to connect people to mental health care and support. Researchers will measure if symptoms improve after six…

This study tests a brief behavioral therapy program delivered via telehealth (STEP-UP) for children and teens aged 8 to 16 with anxiety or depression. Participants are recruited from community health centers and randomly assigned to either STEP-UP or a referral to local mental he…

This study tests a voice-assisted program using Amazon Alexa to help older adults (65+) with depression and their caregivers. Participants use the program for goal setting, reminders, and other mental health support over 12 weeks. Some participants also receive a guide to help th…

This study tests whether inhaling lavender and lemongrass essential oils through a personal necklace can reduce pain and anxiety during active labor. 70 women in labor will be randomly assigned to receive either the aromatherapy or a placebo (sweet almond oil). Researchers will m…

This study tests a program called MSE-PEACE, where parents and children with developmental disabilities (like autism or ADHD) attend 10 sensory sessions together. The goal is to see if it improves children's engagement and emotional control, and helps parents feel more confident …

This study tests a new drug called NS-136 to see if it can ease schizophrenia symptoms. About 150 adults with schizophrenia will take either a low dose, a high dose, or a placebo pill daily for 5 weeks. Researchers will measure changes in symptom scores to check if the drug works…

This study tests an 8-week program called SCERTS for children aged 3 to 6 with mild or moderate autism. The program focuses on improving social communication and emotional regulation while supporting parents. Researchers will measure changes in the child's social skills and the f…

This study tests a digital health tool (CLS-D) that adapts an existing school-based behavioral program for students with ADHD. The goal is to make the program easier for schools with limited resources to use, especially those serving low-income families. About 216 students in 2nd…

This study compares a home-based, tailored sleep therapy (CBT-I) to a web-based version for 80 caregivers who have insomnia while caring for a child with autism. The goal is to see which approach is more acceptable and feasible for improving sleep and reducing caregiver burden. P…

This study tests whether online group counseling can help people who have a permanent colostomy due to colorectal cancer adjust better and improve their psychological well-being and resilience. About 48 adults will be randomly assigned to receive the counseling or not. The goal i…

This study aimed to compare online group cognitive behavioral therapy (CBT) with in-person group CBT for adults with major depression. The goal was to see if online therapy is just as effective and more cost-effective. However, the trial was withdrawn before enrolling any partici…

This pilot study tests whether low-intensity focused ultrasound, guided by MRI, can safely and feasibly target a deep brain region (the thalamus) in people with treatment-resistant schizophrenia. Only 3 participants were planned, and the study is currently suspended. The goal is …

This study tests a virtual reality program where children with autism watch avatars of themselves doing social behaviors like making eye contact and then practice those behaviors. 75 children aged 6-11 will be split into three groups: one gets the VR training, one gets standard t…

This study tests whether injecting a low dose of ketamine directly into the jaw during surgery can reduce pain, swelling, and nausea afterward. Forty adults having corrective jaw surgery will receive either ketamine plus standard anesthetic or standard anesthetic alone. Researche…

This study looks at whether a special type of massage therapy, designed to be sensitive to trauma and different cultures, can help refugees and asylum seekers who survived torture or war. About 50 people will either get their usual care plus this massage, or just usual care. The …

This study compares a new, shorter therapy for Post-Traumatic Stress Disorder (PTSD) to standard treatments. Researchers want to see if the brief approach works just as well at reducing symptoms. About 82 adults with PTSD will take part. The main goal is to measure changes in PTS…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study investigates the link between autism and physical symptoms like gastrointestinal issues, autoimmune diseases, and heart problems. Researchers will compare autistic individuals, people with anxiety or depression, and healthy controls to understand how these symptoms are…

This study uses MRI scans to look at the brains of children and adults with conditions like ADHD, autism, schizophrenia, and endocrine disorders, as well as healthy volunteers. Researchers aim to compare brain anatomy and function across different groups and ages. The goal is to …

This study tests a program called Individual Placement and Support for Autism (IPS-AUT) to help autistic adults ages 18-40 find and keep competitive jobs. Researchers will work with employment agencies to train staff and track job outcomes, satisfaction, and thinking skills. The …

This study follows children from kindergarten through first grade to understand how brain networks involved in reading, math, and executive function (thinking skills like attention and planning) interact to predict academic outcomes. Researchers will also see if these brain and c…

This study looks at a program called the Collaborative Behavioral Health Program (CBHP) for treating depression in primary care. The program brings together primary care doctors, behavioral health managers, and psychiatrists to work as a team. Researchers will track how well the …

This study tests a new program called M-HARP that helps new mothers get health screenings and referrals during their baby's regular doctor visits. About 150 women in the Dominican Republic will take part. The goal is to see if this approach makes it easier for moms to get postpar…

This study looks at how social media and AI-generated beauty standards influence anxiety about appearance in people planning cosmetic surgery. Researchers will survey 145 adults before their procedure to measure social media habits, attitudes toward AI beauty ideals, and social a…

This study tests whether seeing a picture of a supportive friend or family member helps people with social anxiety unlearn fear more effectively. Researchers will compare fear responses in 100 participants (50 with social anxiety, 50 healthy) after pairing threatening cues with e…

This study follows about 2,200 mothers and their children in Cox's Bazar, Bangladesh, including Rohingya refugees and local families. Researchers want to understand how growing up in conflict and displacement affects child development and mental health. They are also looking at w…

This study looks at how parents of autistic young people (ages 12-18) with anorexia nervosa make sense of a group intervention designed for them. Researchers want to understand how parents interpret the concepts from the group and apply them to daily family life, and how they see…

This study looks at whether seeing a picture of a supportive person can help people with social anxiety feel less afraid. Researchers will compare 50 healthy adults and 50 adults with social anxiety disorder. Participants will learn to associate a neutral image with a mild electr…

This study tests a video-based mobile app designed to reduce mental health stigma and medical mistrust among Black adults with moderate to severe depression or anxiety. Participants watch personal stories from others with similar experiences. The goal is to see if this approach i…

This study tests whether coaching or communication classes for primary care clinicians can improve patient satisfaction scores and reduce clinician burnout. About 45 Mayo Clinic providers will take part, filling out questionnaires before, right after, and two months after the tra…

This study looks at how people use their sense of hearing versus physical feeling when they speak. Healthy adults aged 18 to 45 will do speech tasks with altered audio feedback, sometimes with a visual display. Researchers will use a computer model to see if individual difference…

This study is looking at why some people develop persistent pain after breast cancer surgery while others do not. Researchers will follow 220 adults undergoing breast cancer surgery, using questionnaires and a pain sensitivity test to identify risk factors. The goal is to find re…

This study follows thousands of medical interns through their first year of residency—a time of intense, predictable stress—to see how genes and stress together might trigger depression. By tracking mood and genetic markers over 12 months, researchers hope to untangle why some pe…

This study follows people with Phelan-McDermid syndrome, a rare genetic condition linked to autism and intellectual disability, to map how the syndrome unfolds over two years. Researchers will measure changes in thinking, behavior, language, and motor skills, and use brain imagin…

This study will use brain scans to see how cannabis affects inflammation and brain activity in up to 100 U.S. military veterans with PTSD and suicidal thoughts. Participants will take cannabis for 12 weeks and have PET and MRI scans before and after. The goal is to link brain cha…

This study follows individuals with autism who carry a PTEN gene mutation, along with comparison groups, to track changes in thinking, language, and behavior over time. Researchers will also collect blood samples and medical data to build a large database for future studies. The …

This study investigates whether advanced brain imaging and electrical recordings can predict the presence and severity of autism spectrum disorder (ASD) and intellectual disability (ID) in people with tuberous sclerosis complex (TSC). Researchers will follow participants over tim…

This study is testing whether functional MRI brain scans can predict and track how well children and teens with obsessive-compulsive disorder (OCD) respond to a type of therapy called Exposure and Response Prevention (ERP). Thirty participants aged 10 to 17 will receive 14 weekly…

This study looks at how cannabis ads that claim to help with anxiety or depression affect what people buy. About 2,000 light-to-moderate cannabis users with mild to severe anxiety or depression will shop in a realistic online store. Some see ads with mental health claims, others …

This study looks at auditory brainstem evoked potentials (BAEPs) — electrical signals from the brain in response to sound — in children with autism spectrum disorder (ASD). By comparing these signals to those of children with other neuropsychiatric conditions, researchers hope to…

This study explores whether wearable smartwatches can objectively measure activity levels in children with attention-deficit hyperactivity disorder (ADHD). Researchers plan to compare activity data from 50 children with ADHD and 50 neurotypical children over a one-month period. T…

This study uses smartphone data to understand what triggers anxiety and alcohol use in each person, then tailors therapy to those specific triggers. 81 adults with anxiety and alcohol problems will receive 11 sessions of cognitive behavioral therapy (CBT) either personalized to t…

This study looks at brain activity in people already receiving deep brain stimulation (DBS) for severe obsessive-compulsive disorder (OCD). Researchers will collect recordings from the implanted device to see how brain signals relate to OCD symptoms. The goal is to better underst…

This study adapts a 'Health at Every Size' program for pregnant people with a BMI over 30. Ten first-time mothers will attend group sessions on nutrition, movement, and self-advocacy. The goal is to see if the program is acceptable and helpful in reducing weight stigma and improv…

This trial tests whether a six-session financial literacy and gender-equality program for married couples in rural India can change how women and men think about reproductive decision-making for younger generations. Researchers ask participants who should have the main say in whe…

This study follows people treated for anal cancer with radiotherapy to see how their sexual quality of life changes over time. Participants complete questionnaires during treatment, three months later, and two years after diagnosis. The goal is to understand the long-term impact …

This study follows children aged 6 to 21 who have a CNKSR2 gene mutation, which can cause epilepsy, language difficulties, and intellectual disability. Researchers will use brain scans, EEGs, and developmental tests to track how the condition changes over time. The goal is to cre…

This study investigates how the brain suddenly stops speech that is already underway. Researchers will record brain activity from epilepsy patients who already have electrodes implanted for medical reasons, as they perform speech tasks. The goal is to identify the neural circuits…

This study looks at whether combining information from blood samples and smartwatch data can help diagnose major depression and predict when a person moves between active depression and treated depression. Researchers will track symptoms using standard depression rating scales. T…

This study looks at whether an 8-week program of daily brain training exercises, combined with a gentle electrical current applied to the scalp (tDCS), can improve thinking, reduce falls, and help seniors with mental health conditions stay independent. About 270 older adults livi…

This study explores whether attending free community events in renovated neighborhood parks can improve sleep, stress, mood, and overall well-being in adults aged 18 and older who live nearby. Participants wear a smart ring to track sleep and complete surveys over about six month…

This study looks at why about 30-50% of people with bipolar disorder have normal thinking abilities, while others struggle. Researchers will test memory, attention, and problem-solving skills in 87 adults with stable mood. They will also examine sleep, weight, daily routines, and…

This study follows children and adolescents who experienced trauma to see how many still have PTSD or Complex PTSD two years later. Researchers will also look at factors like symptom severity, resilience, sleep, and anxiety that may influence recovery. The goal is to better under…

This study looks at adults with temporomandibular disorders (TMD) — problems with the jaw joint and muscles — to measure how chronic pain, anxiety, depression, and perceived stress relate to each other. Researchers will use standard questionnaires to assess pain severity, depress…

This study compares social cognitive abilities—like recognizing emotions and understanding others' thoughts—in children with autism versus typically developing children aged 2.5 to 14 years. Researchers will use behavioral tasks and eye-tracking to map developmental patterns. The…

This study investigates whether a protein called DISC1, known for its role in schizophrenia, is also linked to heart function in people with the condition. Researchers will measure DISC1 levels in blood and use heart imaging (echocardiograms, cardiac MRI, and ECGs) to assess hear…

This study looks at whether women who took part in a thorough medical investigation after a pregnancy loss (the COPL cohort) had better mental health outcomes one year later compared to those who received standard care. Researchers will analyze data from Danish national registrie…

This study investigates whether changes in brain chemicals (GABA and glutamate) can predict who will respond to ketamine for treatment-resistant depression. Researchers will give two intravenous ketamine infusions to 18 adults and measure chemical levels in the brain and blood. T…

This Phase 1 study aims to understand how the body processes ketamine after a cesarean delivery, and whether it can help with postpartum depression and pain. Fifty participants will receive a low-dose ketamine infusion, and researchers will measure drug levels and side effects. T…

This study investigates how the brain processes speech sounds to understand language. Researchers will record brain activity from people with epilepsy or brain tumors who already have electrodes implanted for medical reasons. Participants listen to short speech sounds while their…

This study investigates how the brain's emotion network works by recording brain activity directly from the surface of the brain in people with epilepsy who are already undergoing surgery for seizure monitoring. Participants watch short video clips designed to trigger emotions li…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study was designed to compare decision-making skills between bipolar patients who had attempted suicide and those who had not. Researchers planned to use computer tasks and questionnaires to measure thinking patterns. However, the study was withdrawn before enrolling any par…

This study aims to uncover the genetic and environmental factors behind autism spectrum disorders (ASD), including autism, Asperger's syndrome, and PDD. Researchers will analyze gene expression in 240 participants aged 18 months and older who have an ASD diagnosis. The goal is to…

This study follows 2,500 people aged 10 and older with depression or bipolar depression over 10 years. Researchers collect data on symptoms, brain scans, genetics, and lifestyle to find patterns that predict how someone will respond to different treatments. No experimental drugs …

This study looks at whether taking short walks throughout the day is better for kids at risk for type 2 diabetes than one longer exercise session. Researchers will measure blood sugar, insulin, and thinking skills in 188 children aged 8-11 with overweight or obesity. The goal is …

This study explores how anxiety contributes to treatment-resistant depression. Researchers will follow 37 adults with depression to see if anxiety levels can predict who will have a harder time recovering. The goal is to better identify at-risk patients and develop more targeted …

This study uses PET and MRI scans to measure brain cell connections in people with major depression or PTSD. Researchers will give ketamine to see if it can reverse synaptic loss linked to these conditions. The goal is to understand brain changes, not to provide treatment. About …

This study looks at whether a mindfulness program can improve attention and brain connectivity in 11-14 year olds who have a family history of mood disorders and high mood swings. About 224 teens will be randomly assigned to mindfulness or a health education class. The goal is to…

This study uses brain scans and behavioral data from 267 adults (80 with autism, 79 with schizophrenia, and 108 healthy controls) to explore shared brain activity patterns related to social thinking. No new treatments are given; researchers analyze existing data to understand how…

This study looks at how the severity of depression relates to erectile dysfunction and premature ejaculation in 100 married men aged 25–60 in the Sohag region of Egypt. Participants are clinically diagnosed with depression and sexually active. Researchers will use standard questi…

This study follows 600 mentally ill offenders in Italy and California over three years to compare two very different treatment systems. Italy uses community-based care, while California relies on long-term hospital stays. Researchers will track violence, recovery, and functioning…

This study adapts an existing stigma-reduction program specifically for pregnant and postpartum women living with HIV in Ghana. Researchers will interview 30 women and 20 providers to understand their experiences, then work with stakeholders to tailor the program. Finally, 90 pre…

This 10-year study follows 1,500 young people aged 10-24 to learn what makes some more resilient to depression and anxiety than others. Researchers will track lifestyle, brain scans, and mental health over time. No treatments or interventions are given—the goal is simply to obser…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study follows 300 Hispanic and Latino caregivers of relatives with memory problems or dementia. Participants complete daily surveys for three weeks at a time, plus follow-ups at six and twelve months, to track how their mood and stress change day-to-day. The goal is to ident…

This study looks at how internet habits, cyberbullying, and emotional coping skills relate to mental health in young people aged 15 to 24. Researchers will survey 50 participants about their internet use, depression, anxiety, and self-harm thoughts. The goal is to better understa…

This study looks at how gut bacteria change when young people (ages 12-35) with psychosis start taking antipsychotic medication. Researchers want to see if these changes are linked to weight gain and other metabolic problems. Participants provide stool and blood samples over 12 w…

This study aims to find which patients with treatment-resistant depression are most likely to get relief from a single low dose of IV ketamine. Researchers will use interviews, questionnaires, brain wave tests, and computer tasks to look for clues. The goal is to make this treatm…

This study looks at whether a single 2-hour group discussion for parents and caregivers can improve eating habits, mood, and parent-child relationships. About 112 Oregon parents of teens (ages 12-17) will either join the talk now or wait. Researchers will measure changes in both …

This study gives ketamine to 120 people with major depression and suicidal thoughts who are not on other psychiatric medications. Researchers use brain scans and a gentle nose swab to see how ketamine changes brain connections and neuron activity. The goal is to understand why ke…

This study looks at how stress influences long-term mood and thinking in 75 older adults with depression. Participants receive standard antidepressant treatment while researchers track their depression severity, memory, and brain activity using MRI scans. The goal is to understan…

This study looks at whether training pediatricians to assess how mothers and babies interact can help identify early signs of child behavior issues or postpartum depression. Over 3,500 mother-child pairs are involved, with babies seen at their one-month checkup. The goal is to se…

This study aimed to see if music therapy and mindfulness meditation could help people who had coronary artery bypass surgery improve their blood pressure, heart rate, anxiety, and depression. It planned to enroll 48 adults who had the surgery and were stable. However, the study w…

This study aimed to see how MDMA changes brain activity in people with PTSD, especially in areas that handle emotions. Researchers planned to give MDMA to a small group and measure brain scans and PTSD symptoms. However, the study was withdrawn before any participants were enroll…

This study aimed to see if using real-time ultrasound during a thoracic epidural block makes the procedure more reliable. It was designed for adults with chest or abdominal pain or rib fractures. The study was withdrawn before enrolling any participants, so no results are availab…

This study observes 35 people in residential treatment for substance use disorders to measure behavioral rigidity—the tendency to get stuck in inflexible thinking patterns. Participants complete weekly questionnaires and have their therapy sessions analyzed for language patterns.…

This study aimed to see if measuring sertraline (Zoloft) levels in the blood and checking a specific gene (CYP2C19) could help doctors give the right dose to people with major depression. The goal was to reduce side effects and improve treatment. However, the study was withdrawn …

This study trains police officers and first responders to better communicate with people who have aphasia, a condition that affects speech and understanding. 75 participants from the Madison Police Department will take part for up to 6 months. The goal is to see if training impro…

This study explores whether playing quiet sounds during a nap can help normalize brain activity and improve memory in people with schizophrenia. Researchers will compare memory and sleep patterns in 70 participants (healthy controls and schizophrenia patients) under two condition…

This study aimed to see if electronic cigarettes could help people with depression smoke less or quit. It planned to follow smokers for 12 months, measuring how many cut down or stopped. However, the study was withdrawn before enrolling anyone, so no results were collected.

This study tests a toolkit called PEACE, designed to help early intervention providers coach parents of young children with autism. Researchers will enroll 200 providers and 400 parent-child dyads to see if the toolkit improves how providers support families. The goal is to make …

This study is testing whether regular cognitive activities (like video games and book clubs) and physical exercises (like walking and Zumba) can slow down age-related decline in thinking and physical health. Researchers are following 400 healthy Malaysian adults aged 60 and older…

This study aimed to see if monthly video calls could help track swallowing issues in people who had intensive rehab after throat cancer treatment. It planned to enroll adults with chronic swallowing problems and check if they could attend at least 3 out of 5 remote sessions. Howe…

This study is testing whether a simple saliva test can help doctors choose the right psychiatric medications for children and teens aged 6 to 24. The test looks at the child's DNA to predict how they might respond to different drugs. Researchers hope this will lead to fewer side …

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study was designed to test whether a technique called self-distancing—where children refer to themselves in the third person (e.g., 'Emily can touch the spider')—helps them approach feared objects more than using first-person self-talk ('I can touch the spider'). The trial p…

This study compares 6 months of group music activities versus circus activities in 200 infants (8-12 months old) with or without a family history of dyslexia. Researchers will measure language skills, brain responses to sounds, and social-emotional factors. The goal is to see if …

This study tests whether low intensity focused ultrasound can change negative thought patterns in people with depression. Researchers will target a key brain network involved in mind-wandering and self-judgment. 80 participants will receive both real and sham ultrasound sessions …

This study looks at health records and insurance claims from nearly 7,000 adults in the U.S. who take KarXT for schizophrenia. Researchers want to understand who gets the drug, how it's used, and how often people need hospital visits. The goal is to see how the medication works i…

This study tests whether an early assessment of activity limitations by occupational therapists can help people with mental disorders return to work. 150 participants in specialized psychiatric care will either receive the assessment or usual care. The goal is to see if this lead…

This study tests a therapy where parents of children with autism (ages 1.5 to 3) get video feedback to help them better understand and respond to their child's signals. The goal is to improve joint attention, a key skill for social communication. Twenty-seven families will be ran…

This study looks at whether anxiety and depression are connected to carpal tunnel syndrome in medical students. Researchers will measure the median nerve in the wrist and check students' anxiety and depression levels using questionnaires. The goal is to see if there is a link bet…

This study aims to find better ways to ensure veterans with PTSD, depression, or alcohol/opioid problems receive proven treatments. Currently, only 3-28% of patients get these effective therapies. Researchers will compare a participatory business engineering method (Participatory…

This study tests a program called 'Enhancing Your Immune Health' for adults with serious mental illness. The program teaches about immune health and how to manage it. Researchers will see if participants report better immune status and feel more confident managing their health.

This study is creating a large registry of 5,000 young people aged 8 to 20 who have depression or suicidal thoughts. Researchers will collect data from clinics across Texas to better understand these conditions and develop models to predict outcomes. The goal is to improve popula…

This study was designed to test the safety and feasibility of a focused ultrasound device called Exablate Neuro with a new Echo-Focusing feature for people with treatment-resistant brain disorders like essential tremor or depression. However, the trial was withdrawn before enroll…

This study looks at why children with autism spectrum disorder (ASD) have trouble imitating others. Researchers will have 201 children aged 8 to 12 perform imitation tasks while recording brain activity with EEG. The goal is to pinpoint where the breakdown happens, which could im…

This early study tests an adaptive deep brain stimulation (aDBS) system in 2 people with severe, treatment-resistant OCD. The device records brain signals to identify patterns linked to OCD distress and stimulation side effects. The goal is not to treat OCD now, but to gather dat…

This study tests a program called Preschool and Me (PreM) that helps families of children with developmental delays or disabilities connect with school-based services. The program uses a care plan and a navigator to guide families through the process. Researchers hope this will i…

This study at Yale University looks at how THC, the active ingredient in cannabis, affects short-term and long-term memory. Researchers will give 80 adults who have used cannabis before either a low dose of THC or a placebo and then test their memory. The goal is to better unders…

This study tests an adaptive deep brain stimulation (aDBS) system in just 3 people with severe, treatment-resistant OCD. The device is implanted in the brain and chest, and it aims to detect brain signals linked to OCD distress and adjust stimulation automatically. The main goal …

This study planned to use a gentle brain stimulation technique called tDCS to see if it could help people with schizophrenia who have negative symptoms (like lack of motivation or emotion). Researchers wanted to use brain scans to understand how it works. However, the study was w…

This study looks at two treatments for severe depression: electroconvulsive therapy (ECT) and antidepressant medication. Researchers want to see which one works better and is more cost-effective in the long run. The study involves 220 adults in the Netherlands who have not gotten…

This study investigates how the brain determines what's important to look at, balancing things that stand out (like bright colors) with things we know are relevant. Researchers will have 240 healthy adults perform visual tasks while measuring their response times and eye movement…

This study looks at how small differences in certain genes affect how people respond to propofol, a common anesthesia drug. Researchers want to understand why some people wake up faster or have more side effects than others. The goal is to help doctors give safer, more personaliz…

This study was designed to test whether scheduled video calls with a nurse could help family members who make medical decisions for hospitalized older adults with Alzheimer's or similar cognitive issues. The goal was to improve communication and reduce anxiety and depression. How…

This study looks at how Transcranial Magnetic Stimulation (TMS) changes the brain in people with major depression. Researchers will use MRI scans to track these changes over 6 weeks. The goal is to better understand how TMS works, not to test a new treatment. 40 adults aged 18-65…

This study aims to see if a short, 4-question Turkish version of the Pain Anxiety Symptom Scale is a reliable and valid tool for measuring pain-related anxiety. Researchers will enroll 350 adults aged 18-65 who have had chronic pain for at least 3 months. Participants will fill o…

This study is testing a digital platform designed to help community health workers (non-specialist providers) feel more confident and skilled when counseling people with anxiety or depression. About 55 English-speaking adults who have already completed a specific training program…

This study follows children born moderately or late preterm (32-36 weeks) to age 9, measuring their thinking, movement, language, behavior, and growth. Researchers compare these kids to full-term peers to understand long-term effects. The goal is to learn how early development pr…

This study aimed to develop and test a 12-week mental health program designed specifically for young South Asian women aged 16-24 with mood or anxiety disorders. The program was meant to address cultural and gender needs. However, the study was withdrawn before any participants w…

This study explores why Black, Indigenous, and People of Color (BIPOC) may have lower rates of starting and sticking with antidepressants after a one-time psychiatric consultation. Researchers will survey 60 adults diagnosed with depression to see if race affects whether they get…

This study follows 2,600 adults with coronary heart disease and depression who received a stent. Researchers track major heart problems like heart attacks or death over one year to find what predicts these events. The goal is to better understand the link between depression and h…

This study tests whether giving doctors a summary of their patient's survey answers before a consultation helps people on sick leave return to work. About 1180 adults in Norway are taking part. The goal is to see if this simple nudge improves recovery and reduces time off work.

This study tests a machine-learning tool that gives doctors a pop-up alert when they prescribe opioids to a patient at high risk of overdose. The alert explains why the patient is at risk and suggests safer options, like prescribing naloxone or referring to pain therapy. Research…

This study tests whether a 12-week program that combines brain training, social activities, and exercise is practical and liked by seniors with mental health conditions living in community housing. About 18 participants will try the program in small groups, guided by a support wo…

This study tests whether a structured educational program can improve primary school teachers' knowledge and classroom skills for managing students with ADHD. 175 teachers who have at least one student with a confirmed ADHD diagnosis will take part. The program covers ADHD basics…

This study tests a brain stimulation technique called paired associative stimulation (PAS) using transcranial magnetic stimulation (TMS) in 72 adults with schizophrenia. The goal is to see if daily sessions over two weeks can improve working memory, as measured by a letter-matchi…

This study follows about 12 children and young adults (ages 4 to 21) with autism who are already using intranasal insulin as part of their regular care. Researchers want to see if this treatment is safe and if it helps with social skills, communication, and behavior over 6 months…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study is developing and testing a smartphone app called R-Assist for people recently released from jail who have both substance use and mental health disorders. The app tracks symptoms, connects users to resources like housing and recovery groups, and measures how easy it is…